Results 91 to 100 of about 4,811,177 (246)

Next Generation Sequencing Identifies Subgroups of Patients With Triple Negative Primary Thrombocytosis With Different Clinical Thrombotic Outcomes

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction The majority of patients with essential thrombocythemia (ET) show somatic mutations of JAK2, CALR, or MPL. Around 10% of cases lack these mutations (“triple negative” ET, TN‐ET). Additionally, some patients with bona fide “primary thrombocytosis” (PT) [i.e., high platelet (PLT)‐ count with no apparent underlying causes] do not ...
Valentina Sangiorgio, Federica Mottadelli, Fabio Pagni, Fabrizio Cavalca, Giovanni Cazzaniga, Martina Venegoni, Carlo Gambacorti‐Passerini, Rocco Piazza, Elena Maria Elli   +8 more
wiley   +1 more source

CLINICAL AND HEMATOLOGICAL ASPECTS OF PRIMARY MYELOFIBROSIS

, 2023
Primary myelofibrosis (PMF) is a chronic clonal stem cell disease that causes an accumulation of marrow fibrosis and dysfunction, hypermetabolic states, and extramedullary myeloid metaplasia. The onset of the disease is often asymptomatic, which causes a late referral to a specialist, the disease being already confirmed in the fibrotic stage with a ...
Andrianova, A., Musteață, L.
openaire   +3 more sources

A Case of Primary Autoimmune Myelofibrosis [PDF]

The Korean Journal of Hematology, 2009
Myelofibrosis is usually observed in association with hematologic malignancies or metastatic solid tumors, but it has rarely been reported in patients who suffer with autoimmune disorders. Autoimmune myelofibrosis is a distinct clinicopathologic entity and it can occur alone or in association with autoimmune disorders, and the final result is chronic ...
Jeong Yeal Ahn, Pil Hwan Park, Jinny Park, Soon Ho Park, Yiel Hea Seo, Kyung-Hee Kim, Jung-Eun Kim, Young Hee Song   +7 more
openaire   +1 more source

Systematization of analytical studies of polycythemia vera, essential thrombocythemia and primary myelofibrosis, and a meta-analysis of the frequency of JAK2, CALR and MPL mutations: 2000–2018

BMC Cancer, 2019
Research into Philadelphia-negative chronic myeloproliferative neoplasms is heterogeneous. In addition, no systematization of studies of polycythemia vera (PV), essential thrombocythemia (ET) or primary myelofibrosis (PMF) have been carried out.
Mónica Mejía-Ochoa, Paola Andrea Acevedo Toro, JA Cardona-Arias   +2 more
semanticscholar   +1 more source

Long-term results of splenectomy in primary myelofibrosis

Онкогематология, 2014
The estimation of immediate and long-term results after splenectomy depending on indications and contra-indications for 18 primary myelofibrosis (PMF) patients was shown.
L. M. Meshcheryakova, L. G. Kovaleva, S. R. Karagyulyan, L. Yu. Kolosova, O. V. Porotkova, Ye. A. Semenova   +5 more
doaj   +3 more sources

Distinct clinical characteristics of myeloproliferative neoplasms with calreticulin mutations

Haematologica, 2014
Somatic insertions/deletions in the calreticulin gene have recently been discovered to be causative alterations in myeloproliferative neoplasms. A combination of qualitative and quantitative allele-specific polymerase chain reaction, fragment-sizing ...
Hajnalka Andrikovics, Tunde Krahling, Katalin Balassa, Gabriella Halm, Andras Bors, Magdalena Koszarska, Arpad Batai, Janos Dolgos, Judit Csomor, Miklos Egyed, Andrea Sipos, Peter Remenyi, Attila Tordai, Tamas Masszi   +13 more
doaj   +1 more source

Neurological manifestations of chronic graft versus host disease

Internal Medicine Journal, EarlyView.
Abstract Introduction Allogeneic haemopoietic stem cell transplant (allo‐HSCT) is an established therapy for many malignant and non‐malignant conditions, with an increasing number of uses and indications in recent decades. Complications including graft versus host disease (GvHD) carry significant morbidity and mortality.
Tal Koren, Alice Kwok, William Stevenson, Kate Ahmad, Joseph Nogajski, John Parratt, Ian Kerridge, Karl Ng   +7 more
wiley   +1 more source

Platelet-derived growth factor receptor β activation and regulation in murine myelofibrosis

Haematologica, 2020
There is prevailing evidence to suggest a decisive role for platelet-derived growth factors (PDGF) and their receptors in primary myelofibrosis. While PDGF receptor β (PDGFRβ) expression is increased in bone marrow stromal cells of patients correlating ...
Frederike Kramer, Jens Dernedde, Artur Mezheyeuski, Rudolf Tauber, Patrick Micke, Kai Kappert   +5 more
doaj   +1 more source

Management Strategies for Refractory Esophageal Varices

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Refractory esophageal varices that are difficult to control or unresponsive to endoscopic treatment remain a major clinical challenge in the management of portal hypertension. This review provides a comprehensive overview of treatment strategies for these cases, along with a comparative analysis of the American Association for the Study of ...
Keita Maki, Hiroaki Haga, Yoshiyuki Ueno
wiley   +1 more source

Calreticulin mutations in Chinese with primary myelofibrosis

Haematologica, 2014
We tested 357 Chinese with primary myelofibrosis for mutations in CALR, JAK2 and MPL. CALR mutations were detected in 76 subjects (21%). There were 24 (32%) type-1 (L367fs*46) and 49 (64%) type-2 (K385fs*47) mutations. Seventy-two of 168 subjects (43%) without a JAK2 or MPL mutation had a CALR mutation.
Tiejun Qin, Yajuan Cui, Ruixian Xing, Robert Peter Gale, Zefeng Xu, Junqing Xu, Jingya Wang, Zhijian Xiao, Xiaofei Ai, Bing Li, Lin Yang, Yue Zhang, Peihong Zhang   +12 more
openaire   +4 more sources