Results 71 to 80 of about 4,315,874 (223)

CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis

Haematologica, 2009
CD146+ bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment.
Claudio Tripodo, Andrea Di Bernardo, Maria Paola Ternullo, Carla Guarnotta, Rossana Porcasi, Sabrina Ingrao, Umberto Gianelli, Emanuela Boveri, Emilio Iannitto, Giovanni Franco, Ada Maria Florena   +10 more
doaj   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

British Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco, Patrick Harrington, Elena Torre, Hillary Catellani, Novella Pugliese, Matteo Pacilli, Annalisa Santisi, Arianna Sbriglione, Giuseppe A. Palumbo   +8 more
wiley   +1 more source

Primary Myelofibrosis - 5

, 2018
An image from a peripheral blood smear showing tears, elliptocytes, schistocytes, and a giant platelet seen in patients with primary myelofibrosis (50X oil immersion).
To, Michelle, Kwon, Gloria
core   +1 more source

Distinct clinical, molecular, and treatment response profiles in primary and secondary myelofibrosis: a single-center retrospective study

Hematology
Background Myelofibrosis (MF) includes primary myelofibrosis (PMF) and secondary myelofibrosis (SMF) evolving from essential thrombocythemia (ET) or polycythemia vera (PV). The clinical and molecular heterogeneity of MF remains incompletely characterized
Wenya Liu, Yue Ren, Yingao Liang, Yumei Liu, Liyan Yang, Xifeng Dong, Limin Xing, Zonghong Shao, Rong Fu, Huaquan Wang   +9 more
doaj   +1 more source

Primary Myelofibrosis - 2

, 2018
An image from a peripheral blood smear showing RBC poikilocytosis: tears, elliptocytes, and schistocytes in a patient with primary myelofibrosis. A large platelet (top), Neutrophil, and nucleated RBC (center) are also seen (50X oil immersion)
To, Michelle, Kwon, Gloria
core   +1 more source

Molecular analyses of 15,542 patients with suspected BCR-ABL1-negative myeloproliferative disorders allow to develop a stepwise diagnostic workflow

Haematologica, 2012
We investigated 15,542 patients with suspected BCR-ABL1- negative myeloproliferative or myelodysplastic/myeloproliferative neoplasm (including 359 chronic myelomonocytic leukemia) by a molecular marker set.
Susanne Schnittger, Ulrike Bacher, Christiane Eder, Frank Dicker, Tamara Alpermann, Vera Grossmann, Alexander Kohlmann, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach   +9 more
doaj   +1 more source

Venous Thromboembolism in Hematologic Malignancies: Incidence, Risk Factors, and the Role of Direct Oral Anticoagulants

European Journal of Haematology, EarlyView.
ABSTRACT Thrombotic events, particularly venous thromboembolism (VTE), are a significant source of morbidity and mortality among patients with hematologic malignancies. These patients face unique challenges due to treatment‐related complications such as thrombocytopenia, coagulopathy, and heightened bleeding risk.
Mario Biglietto, Silvia Sorella, Erminia Baldacci, Massimo Breccia, Sabina Chiaretti, Marcello Capriata, Livia Donzelli, Gianna Maria D'Elia, Salvatore Giacomo Morano, Ilaria Del Giudice, Maurizio Martelli, Cristina Santoro, Antonio Chistolini   +12 more
wiley   +1 more source

Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation. Methods We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion ...
Mathias Lazarevic Lindblad, Elin Pålsson, Vladimir Lazarevic, Leila Naddi, Ola Borgquist, Lars Nilsson, Maria Adrian, Björn P. Bark, Thomas Kander   +8 more
wiley   +1 more source

Primary Myelofibrosis - 4

, 2018
An image from a peripheral blood smear showing tears, elliptocytes, and schistocytes seen in a patient with primary myelofibrosis (50X oil immersion).
To, Michelle, Kwon, Gloria
core   +1 more source

Targeted Therapy of Myelofibrosis

Клиническая онкогематология, 2017
Background. Myelofibrosis (primary myelofibrosis, post-essential trombocythemia myelofibrosis, post-polycythemia myelofibrosis) is the most complex and pressing problem among all Ph-negative myeloproliferative diseases. The present article summarizes the
Ol’ga Yur’evna Vinogradova, V. A. Shuvaev, I. S. Martynkevich, M. M. Pankrashkina, M. S. Fominykh, E. V. Efremova, K. Yu. Krutikova, L. B. Polushkina, N. N. Sharkunov, S. V. Voloshin, A. V. Chechetkin   +10 more
doaj   +1 more source