Results 91 to 100 of about 27,057 (223)

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated

Haematologica, 2019
In this study we interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpG, corresponding to 10,253 genes, between myelofibrosis patients and healthy controls ...
Nicolás Martínez-Calle, Marien Pascual, Raquel Ordoñez, Edurne San José Enériz, Marta Kulis, Estíbaliz Miranda, Elisabeth Guruceaga, Víctor Segura, María José Larráyoz, Beatriz Bellosillo, María José Calasanz, Carles Besses, José Rifón, José I. Martín-Subero, Xabier Agirre, Felipe Prosper   +15 more
doaj   +1 more source

Aktualitások a primer myelofibrosis ellátásában | Actualities in the management of primary myelofibrosis [PDF]

, 2016
Absztrakt A primer myelofibrosis a Philadelphia-negatív krónikus myeloid neoplasiák közé tartozó ritka kórkép, amelyre jellemző a cytopeniák és hepatosplenomegalia kialakulása.
Borbényi, Zita, Illés, Árpád, Marton, Imelda, Simon, Zsófia   +3 more
core   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source

Childhood primary myelofibrosis presented with headache, splenomegaly, and severe thrombocytosis: A case report

Indian Journal of Medical and Paediatric Oncology, 2018
Primary myelofibrosis (PMF) is a clonal disorder of a multipotent hematopoietic progenitor cell that occurs predominantly in the elderly age group. We report here an 11-year-old girl who presented with headache, fever, and splenomegaly.
Athanasios Tragiannidis, Athanasia Apsemidou, Ioannis Liampas, Triantafyllia Koletsa   +3 more
doaj   +1 more source

Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis

Haematologica, 2013
Megakaryocytes release platelets into the bloodstream by elongating proplatelets. In this study, we showed that human megakaryocytes constitutively release Transforming Growth Factor β1 and express its receptors.
Stefania Badalucco, Christian Andrea Di Buduo, Rita Campanelli, Isabella Pallotta, Paolo Catarsi, Vittorio Rosti, David L. Kaplan, Giovanni Barosi, Margherita Massa, Alessandra Balduini   +9 more
doaj   +1 more source

Differential Diagnoses of Systemic Mastocytosis in Routinely Processed Bone Marrow Biopsy Specimens: A Review [PDF]

, 2010
Diagnosis of systemic mastocytosis (SM) is mainly based on the morphological demonstration of compact mast cell infiltrates in various tissue sites. In almost all patients such infiltrates are detected in the bone marrow.
Horny, H. -P., Sotlar, K., Valent, P.
core   +1 more source

Ruxolitinib Treatment in a Patient with Primary Myelofibrosis Resistant to Conventional Therapies and Splenectomy: A Case Report

Turkish Journal of Hematology, 2015
A 67-year-old male patient who was diagnosed with primary myelofibrosis 4 years ago did not respond to conventional therapies. The splenomegaly progressively increased, which caused spleen infarctions and led to the decision to perform a splenectomy ...
Meltem Aylı, Muhit Özcan, Güldane Cengiz Seval   +2 more
doaj   +1 more source

Canonical Wnt/β-catenin signaling pathway is dysregulated in patients with primary and secondary myelofibrosis [PDF]

, 2016
INTRODUCTION: β-Catenin is a central effector molecule of the canonical wingless-related integration site (Wnt) signaling pathway. It is important for maintenance of stem cell homeostasis and its aberrant activation has been implicated in a wide ...
Jakšić, Ozren, Kušec, Rajko, Livun, Ana, Lucijanić, Marko, Pejša, Vlatko, Prka, Željko, Tomasović-Lončarić, Čedna, Štoos-Veić, Tajana   +7 more
core   +1 more source

Urticarial vasculitis coexisting with primary myelofibrosis – a case report

Przegląd Dermatologiczny, 2017
Introduction . Urticarial vasculitis is a subtype of cutaneous leukocytoclastic vasculitis. The disease often accompanies systemic disorders, including hematologic malignancies, connective tissue diseases, and infectious diseases, or may be drug-induced.
Radomir Reszke, Adam Reich
doaj   +1 more source

Localized Tuberculosis and Myelofibrosis with Myeloid Metaplasia : An extremely unusual presentation [PDF]

, 1996
Myelofibrosis with myeloid metaplasia (MMM) is usually considered primary agnogenic, however, it may be secondary to various diseases, The association of tuberculosis with MMIM is exceedingly rare, however, the pathogenetic relationship between the two ...
Muzaffar, Suhail
core   +1 more source