Results 101 to 110 of about 4,811,177 (246)

Epigenomic profiling of myelofibrosis reveals widespread DNA methylation changes in enhancer elements and ZFP36L1 as a potential tumor suppressor gene that is epigenetically regulated

Haematologica, 2019
In this study we interrogated the DNA methylome of myelofibrosis patients using high-density DNA methylation arrays. We detected 35,215 differentially methylated CpG, corresponding to 10,253 genes, between myelofibrosis patients and healthy controls ...
Nicolás Martínez-Calle, Marien Pascual, Raquel Ordoñez, Edurne San José Enériz, Marta Kulis, Estíbaliz Miranda, Elisabeth Guruceaga, Víctor Segura, María José Larráyoz, Beatriz Bellosillo, María José Calasanz, Carles Besses, José Rifón, José I. Martín-Subero, Xabier Agirre, Felipe Prosper   +15 more
doaj   +1 more source

Final Results From a Large, Non‐Interventional, Phase 4 Study of Ruxolitinib for the Treatment of Myelofibrosis in Clinical Routine

European Journal of Haematology, Volume 115, Issue 4, Page 380-390, October 2025.
ABSTRACT JAKoMo was a long‐term, multicenter, non‐interventional study observing the efficacy, safety, and quality of life (QOL) effects of ruxolitinib (RUX), managed per clinical routine at investigator discretion, for treatment of 943 patients with myelofibrosis (MF) in 122 German centers.
Steffen Koschmieder, Susanne Isfort, Clemens Schulte, Lutz Jacobasch, Thomas Geer, Marcel Reiser, Michael Koenigsmann, Bernhard Heinrich, Jürgen Wehmeyer, Eyck von der Heyde, Hans Tesch, Benedikt Gröschl, Petra Bachhuber, Susanne Großer, Michael Koehler, Heike L. Pahl   +15 more
wiley   +1 more source

Fibrocytes in primary myelofibrosis

Oncotarget, 2021
Kazuya Shimoda, Kotaro Shide, Yoshinori Ozono   +2 more
openaire   +2 more sources

Contraception in Myeloproliferative Neoplasms: A Pharmacological Review

European Journal of Haematology, Volume 115, Issue 4, Page 344-348, October 2025.
ABSTRACT Myeloproliferative neoplasms (MPNs) are chronic hematologic disorders characterized by clonal proliferation of myeloid lineage cells, commonly driven by JAK2 mutations, and associated with significant thrombotic and hemorrhagic complications.
Awni Alshurafa, Maria Benkhadra, Anas M. Babiker, Wafa M. Mohammed, Mohamed A. Yassin   +4 more
wiley   +1 more source

Persistent Basophilia May Suggest an “Accelerated Phase” in the Evolution of CALR-Positive Primary Myelofibrosis Toward Acute Myeloid Leukemia

Frontiers in Oncology, 2019
Basophils are white blood cells that play an important role in the human immune system. These cells physiologically increase in number in immune response to certain allergies, chronic inflammation, and parasitic infections.
J. Dobrowolski, Sergiu Pasca, Patric Teodorescu, C. Selicean, Ioana Rus, M. Zdrenghea, A. Bojan, A. Trifa, B. Fetica, B. Petrushev, A. Rosu, I. Berindan‐Neagoe, C. Tomuleasa, D. Dima   +13 more
semanticscholar   +1 more source

Myeloid sarcoma shows a high frequency of mutations activating the MAPK/ERK pathway and association with clonal hematopoiesis

The Journal of Pathology: Clinical Research, Volume 11, Issue 5, September 2025.
Abstract Myeloid sarcoma (MS) is a mass‐forming extramedullary manifestation of myeloid blasts, either in relation to an underlying acute myeloid leukemia (AML), another myeloid neoplasm (MN) or as a de novo occurrence. Data on the genetic profile of MS are sparse.
Dominik Nann, Tim‐Colin Schade, Mathis Overkamp, Lejla Mahmutovic, Eyyub Bag, Stephan Forchhammer, Julia Slotta‐Huspenina, Ludmila Boudova, Karl Sotlar, Leticia Quintanilla‐Martinez, Irina Bonzheim, Falko Fend   +11 more
wiley   +1 more source

Revised “iRR6” model in intermediate‐1 risk myelofibrosis patients treated with ruxolitinib

Cancer, Volume 131, Issue 17, 1 September 2025.
Abstract Background The response to ruxolitinib after 6 months (RR6) model allows early identification of ruxolitinib‐treated myelofibrosis (MF) patients with poorer overall survival (OS); however, it is less applicable to lower‐risk patients. Methods To further explore this, the authors performed a subanalysis of the “RUX‐MF” study (NCT06516406) with ...
Francesca Palandri, Filippo Branzanti, Massimiliano Bonifacio, Elena M. Elli, Erika Morsia, Mirko Farina, Mario Tiribelli, Giulia Benevolo, Eloise Beggiato, Bruno Martino, Giovanni Caocci, Novella Pugliese, Alessia Tieghi, Monica Crugnola, Gianni Binotto, Francesco Cavazzini, Elisabetta Abruzzese, Alessandro Isidori, Alessandra Dedola, Emilia Scalzulli, Andrea Duminuco, Luca Tosoni, Alda Strazimiri, Roberto M. Lemoli, Daniela Cilloni, Monica Bocchia, Fabrizio Pane, Chiara Sartor, Florian H. Heidel, Massimo Breccia, Giuseppe A. Palumbo, Andrew T. Kuykendall   +31 more
wiley   +1 more source

Evidence for prevention of renal dysfunction associated with primary myelofibrosis by cytoreductive therapy

Haematologica, 2019
Myeloproliferative neoplasms (MPN), such as polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) are characterized by the expansion of myeloid lineage cells caused by an acquired driver mutation, such as JAK2 V617F ...
Y. Fukuda, Marito Araki, Kouji Yamamoto, S. Morishita, Tadaaki Inano, K. Misawa, Tomonori Ochiai, Y. Edahiro, M. Imai, H. Yasuda, A. Gotoh, A. Ohsaka, N. Komatsu   +12 more
semanticscholar   +1 more source

Childhood primary myelofibrosis presented with headache, splenomegaly, and severe thrombocytosis: A case report

Indian Journal of Medical and Paediatric Oncology, 2018
Primary myelofibrosis (PMF) is a clonal disorder of a multipotent hematopoietic progenitor cell that occurs predominantly in the elderly age group. We report here an 11-year-old girl who presented with headache, fever, and splenomegaly.
Athanasios Tragiannidis, Athanasia Apsemidou, Ioannis Liampas, Triantafyllia Koletsa   +3 more
doaj   +1 more source

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways

JOR SPINE, Volume 8, Issue 3, September 2025.
The senescence of NPCs is at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back discomfort. ABSTRACT Background The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain.
Yunbo Yang, Haoming Li, Junhui Zuo, Fei Lei   +3 more
wiley   +1 more source