Results 111 to 120 of about 4,811,177 (246)

Transforming Growth Factor‐Beta Signaling in Cancer: Therapeutic Implications, Challenges, and Pathways to Progress

open access: yesMedComm – Oncology, Volume 4, Issue 3, September 2025.
TGF‐β inhibition is emerging as a promising cancer therapy, yet translating laboratory success to bedside implementation has suffered significant setbacks. The associated challenges include adverse drug reactions, inadequate predictive models, and activation of alternative signaling pathways.
Faizah A. Alabi   +5 more
wiley   +1 more source

WHO Reporting System for Lung Cytopathology: Insights Into the Insufficient/Inadequate/Non‐Diagnostic, Atypical and Suspicious for Malignancy Categories and How to Use Them

open access: yesCytopathology, Volume 36, Issue 5, Page 434-442, September 2025.
The WHO System is an international effort to standardise category definitions, establish the key diagnostic cytopathological features of entities of the lung, propose the best use of ancillary tests in lung specimens, encourage the use of standardised pathology reports containing essential components in an integrated report and propose estimates of the
Zahra Maleki, Sule Canberk, Andrew Field
wiley   +1 more source

Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis

open access: yesJournal of Experimental Medicine, 2016
Estrov and collaborators examine the role of fibrocytes in primary myelofibrosis and propose a novel therapeutic approach.
S. Verstovsek   +17 more
semanticscholar   +1 more source

Imaging Findings of Congenital Distal Interphalangeal Joint Dysplasia in a 3‐Month‐Old Friesian Foal

open access: yesVeterinary Radiology &Ultrasound, Volume 66, Issue 5, September 2025.
ABSTRACT A 3‐month‐old Friesian colt presented with severe, progressive distal limb lameness in two limbs. Radiographic and postmortem full‐body CT imaging revealed severe articular deforming osteolysis and osteoproliferation at the dorsodistal navicular bone margin and the adjacent distal phalanx proximo‐palmar/proximo‐plantar margin in two limbs ...
Emmie J. M. Giessen   +3 more
wiley   +1 more source

Megakaryocytes morphology in idiopathic (primary) myelofibrosis

open access: yesReports of Practical Oncology & Radiotherapy, 2004
SummaryBackgroundThe cause of idiopathic myelofibrosis (IM) originating from a haemopoietic stem cells with development of secondary marrow fibrosis is unknown. Increased production of platelet-derived growth factor by megakaryocytes causes amplified activity of fibroblasts.
Iryna N. Kabachenko   +2 more
openaire   +2 more sources

Ruxolitinib Treatment in a Patient with Primary Myelofibrosis Resistant to Conventional Therapies and Splenectomy: A Case Report

open access: yesTurkish Journal of Hematology, 2015
A 67-year-old male patient who was diagnosed with primary myelofibrosis 4 years ago did not respond to conventional therapies. The splenomegaly progressively increased, which caused spleen infarctions and led to the decision to perform a splenectomy ...
Meltem Aylı   +2 more
doaj   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

open access: yes
Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson   +5 more
wiley   +1 more source

Validation of the WHO-defined 20% circulating blasts threshold for diagnosis of leukemic transformation in primary myelofibrosis

open access: yesBlood Cancer Journal, 2018
Leukemic transformation is the most dreaded complication in patients with myeloproliferative neoplasms (MPN); overall risk is estimated at 14% for primary myelofibrosis (PMF), 7% for polycythemia vera (PV) and 4% for essential thrombocythemia (ET).
M. Mudireddy   +5 more
semanticscholar   +1 more source

Primary and Secondary Myelofibrosis: Its Relationship to "PNH-like Defect" [PDF]

open access: bronze, 1972
Chi-yen Kuo   +2 more
openalex   +1 more source

U2AF1 mutation types in primary myelofibrosis: phenotypic and prognostic distinctions

open access: yesLeukemia, 2018
myeloid leukemia. Blood. 2013;121:2213–23. 4. Yin JA, O’Brien MA, Hills RK, Daly SB, Wheatley K, Burnett AK. Minimal residual disease monitoring by quantitative RT-PCR in core binding factor AML allows risk stratification and predicts relapse: results of
A. Tefferi   +6 more
semanticscholar   +1 more source

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