Results 131 to 140 of about 4,938,261 (300)

Persistent Basophilia May Suggest an “Accelerated Phase” in the Evolution of CALR-Positive Primary Myelofibrosis Toward Acute Myeloid Leukemia

Frontiers in Oncology, 2019
Basophils are white blood cells that play an important role in the human immune system. These cells physiologically increase in number in immune response to certain allergies, chronic inflammation, and parasitic infections.
J. Dobrowolski, Sergiu Pasca, Patric Teodorescu, C. Selicean, Ioana Rus, M. Zdrenghea, A. Bojan, A. Trifa, B. Fetica, B. Petrushev, A. Rosu, I. Berindan‐Neagoe, C. Tomuleasa, D. Dima   +13 more
semanticscholar   +1 more source

Acute Myeloid Leukemia Secondary to Radiation Therapy for Rectal Cancer: A Case Report

Cancer Reports, Volume 8, Issue 12, December 2025.
ABSTRACT Background Therapy‐related AML (t‐AML) is a subtype of acute myeloid leukemia (AML) that arises in the bone marrow and primarily affects white blood cells. It is associated with prior exposure to cytotoxic agents, including chemotherapy and radiotherapy. The risk of the disease increases with age and treatment intensity.
Ahmad Alkhaledi, Laila Alhaj Hussaen, Linda Kahla, Baraa Sammoud, Suha Giselle Ghanem   +4 more
wiley   +1 more source

Aktualitások a primer myelofibrosis ellátásában | Actualities in the management of primary myelofibrosis [PDF]

, 2016
Absztrakt A primer myelofibrosis a Philadelphia-negatív krónikus myeloid neoplasiák közé tartozó ritka kórkép, amelyre jellemző a cytopeniák és hepatosplenomegalia kialakulása.
Borbényi, Zita, Illés, Árpád, Marton, Imelda, Simon, Zsófia   +3 more
core   +1 more source

Atypical chronic myeloid leukemia: From diagnosis to molecular features and therapeutic options

HemaSphere, Volume 9, Issue 12, December 2025.
ABSTRACT Atypical chronic myeloid leukemia (aCML) is a rare form of myelodysplastic (MDS)/myeloproliferative neoplasm (MPN) overlap disorder characterized by neutrophilic leukocytosis with circulating immature myeloid cells (IMC), frequent hepatosplenomegaly, and poor prognosis with high rates of leukemic transformation.
Alessandra Iurlo, Daniele Cattaneo, Umberto Gianelli, Francesco Passamonti   +3 more
wiley   +1 more source

Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis

Haematologica, 2013
Megakaryocytes release platelets into the bloodstream by elongating proplatelets. In this study, we showed that human megakaryocytes constitutively release Transforming Growth Factor β1 and express its receptors.
Stefania Badalucco, Christian Andrea Di Buduo, Rita Campanelli, Isabella Pallotta, Paolo Catarsi, Vittorio Rosti, David L. Kaplan, Giovanni Barosi, Margherita Massa, Alessandra Balduini   +9 more
doaj   +1 more source

Budd-Chiari syndrome recurring in a transplanted liver [PDF]

, 1983
A patient with Budd-Chiari syndrome who underwent orthotopic liver transplantation and developed recurrent disease is described. The immediate postoperative period was complicated by multiple thrombotic episodes, followed by a period of apparent ...
Andrew Dekker, Asbury, Bras, Calne, Dane R. Boggs, David H. Van Thiel, Howard J. Seltman, Mitchel, Parker, Putnam, Takeuchi, Thomas E. Starzl   +11 more
core   +1 more source

What's Your Diagnosis? A Case of Extreme Thrombocytosis in a Dog

Veterinary Clinical Pathology, EarlyView.
Stephanie F. Anderson, King Long Hannah Lee, Megan Dietz, Sarah Guess, Laura White, Mara S. Varvil   +5 more
wiley   +1 more source

Extracorporeal Photopheresis for Chronic Graft‐Versus‐Host Disease According to 2014 NIH Consensus Criteria

Journal of Clinical Apheresis, Volume 40, Issue 6, December 2025.
ABSTRACT Chronic graft‐versus‐host disease (cGVHD) remains a major cause of morbidity and mortality following allogeneic hematopoietic stem cell transplantation. Many cGVHD patients require prolonged systemic immunosuppression with corticosteroids, which carry significant adverse effects, and alternative therapies are often required.
Yitzhar Goretsky, Noa Holtzman, Sunwoo Han, Isildinha M. Reis, Vera Suzuki, Pepita Jean, Karla Mones, Meilin Diaz‐Paez, Cara Benjamin, Amer Beitinjaneh, Mark Goodman, Antonio Jimenez Jimenez, Lazaros Lekakis, Denise Pereira, Jay Spiegel, Yanyun Wu, Damian J. Green, Krishna V. Komanduri, Trent P. Wang   +18 more
wiley   +1 more source

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies [PDF]

, 2016
The Src family kinase (SFK)member SRC is amajor target in drug development because it is activated in many human cancers, yet deleterious SRC germline mutations have not been reported. We used genome sequencing and Human Phenotype Ontology patient coding
,, Ashford, Sofie, Attwood, Antony, Austin, Steve, Bakchoul, Tamam, Bariana, Tadbir K, Bradley, John R, Collins, Peter, De Maeyer, Marc, Deevi, Sri V V, Erber, Wendy N, Favier, Rémi, Freson, Kathleen, Gomez, Keith, Greene, Daniel, Kelly, Anne M, Kostadima, Myrto, Laffan, Michael A, Lambert, Michele P, Lentaigne, Claire, Lucy Raymond, F, Mathias, Mary, Millar, Carolyn M, Mumford, Andrew D, Nurden, Paquita, Ouwehand, Willem H, Papadia, Sofia, Peerlinck, Kathelijne, Penkett, Christopher J, Perry, David J, Rendon, Augusto, Richardson, Sylvia, Schulman, Sol, Selleslag, Dominik, Simeoni, Ilenia, Stephens, Jonathan C, Stirrups, Kathleen, Thys, Chantal, Turro, Ernest, Van Geet, Chris, Westbury, Sarah K, Whitehorn, Deborah, Wijgaerts, Anouck, Wittevrongel, Christine   +43 more
core   +1 more source

Targeted Therapy for Idiopathic Inflammatory Myopathy

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 6, December 2025.
ABSTRACT Background Idiopathic inflammatory myopathies (IIM) are a heterogeneous group of autoimmune disorders characterized by chronic muscle inflammation and significant extramuscular involvement. A substantial proportion of patients exhibit refractory or relapsing disease despite conventional immunosuppressive therapies, necessitating the ...
Ruijie Wang, Wei Lin, Qibing Xie, Geng Yin   +3 more
wiley   +1 more source