Results 131 to 140 of about 4,984,276 (289)

Involvement of TGFβ1 in autocrine regulation of proplatelet formation in healthy subjects and patients with primary myelofibrosis

Haematologica, 2013
Megakaryocytes release platelets into the bloodstream by elongating proplatelets. In this study, we showed that human megakaryocytes constitutively release Transforming Growth Factor β1 and express its receptors.
Stefania Badalucco, Christian Andrea Di Buduo, Rita Campanelli, Isabella Pallotta, Paolo Catarsi, Vittorio Rosti, David L. Kaplan, Giovanni Barosi, Margherita Massa, Alessandra Balduini   +9 more
doaj   +1 more source

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies [PDF]

, 2016
The Src family kinase (SFK)member SRC is amajor target in drug development because it is activated in many human cancers, yet deleterious SRC germline mutations have not been reported. We used genome sequencing and Human Phenotype Ontology patient coding
,, Ashford, Sofie, Attwood, Antony, Austin, Steve, Bakchoul, Tamam, Bariana, Tadbir K, Bradley, John R, Collins, Peter, De Maeyer, Marc, Deevi, Sri V V, Erber, Wendy N, Favier, Rémi, Freson, Kathleen, Gomez, Keith, Greene, Daniel, Kelly, Anne M, Kostadima, Myrto, Laffan, Michael A, Lambert, Michele P, Lentaigne, Claire, Lucy Raymond, F, Mathias, Mary, Millar, Carolyn M, Mumford, Andrew D, Nurden, Paquita, Ouwehand, Willem H, Papadia, Sofia, Peerlinck, Kathelijne, Penkett, Christopher J, Perry, David J, Rendon, Augusto, Richardson, Sylvia, Schulman, Sol, Selleslag, Dominik, Simeoni, Ilenia, Stephens, Jonathan C, Stirrups, Kathleen, Thys, Chantal, Turro, Ernest, Van Geet, Chris, Westbury, Sarah K, Whitehorn, Deborah, Wijgaerts, Anouck, Wittevrongel, Christine   +43 more
core   +2 more sources

Second primary malignancies in postpolycythemia vera and postessential thrombocythemia myelofibrosis: A study on 2233 patients [PDF]

, 2019
Barbara Mora, Elisa Rumi, Paola Guglielmelli, Daniela Barraco, Margherita Maffioli, Alessandro Rambaldi, Marianna Caramella, Rami S. Komrokji, Jason Gotlib, Jean‐Jacques Kiladjian, Francisco Cervantes, Timothy Devos, Francesca Palandri, Valerio De Stefano, Marco Ruggeri, Richard T. Silver, Giulia Benevolo, Francesco Albano, Chiara Cavalloni, Daniela Pietra, Tiziano Barbui, Giada Rotunno, Mario Cazzola, Alessandro M. Vannucchi, Toni Giorgino, Francesco Passamonti   +25 more
openalex   +1 more source

Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. [PDF]

, 2014
Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation.
de Haan, Gerald, Green, Anthony R, Kent, David G, Prick, Janine   +3 more
core   +1 more source

Primary myelofibrosis marrow-derived CD14+/CD34- monocytes induce myelofibrosis-like phenotype in immunodeficient mice and give rise to megakaryocytes

PLoS ONE, 2019
To confirm that neoplastic monocyte-derived collagen- and fibronectin-producing fibrocytes induce bone marrow (BM) fibrosis in primary myelofibrosis (PMF), we injected PMF BM-derived fibrocyte-precursor CD14+/CD34- monocytes into the tail vein of NOD ...
T. Manshouri, S. Verstovsek, D. Harris, Ivo Veletic, Xiaorui Zhang, S. Post, C. Bueso-Ramos, Z. Estrov   +7 more
semanticscholar   +1 more source

A3669G polymorphism of glucocorticoid receptor is a susceptibility allele for primary myelofibrosis and contributes to phenotypic diversity and blast transformation [PDF]

, 2012
Valentina Poletto, Vittorio Rosti, Laura Villani, Paolo Catarsi, Adriana Carolei, Rita Campanelli, Margherita Massa, Myriam Martinetti, Gianluca Viarengo, Alberto Malovini, Anna Ritá Migliaccio, Giovanni Barosi   +11 more
openalex   +1 more source

P1058: REAL-WORLD OUTCOMES WITH FEDRATINIB THERAPY IN PATIENTS WITH PRIMARY MYELOFIBROSIS POST-RUXOLITINIB DISCONTINUATION

, 2022
Francesco Passamonti, Ying Lou, Manoj Chevli, P. Abraham   +3 more
openalex   +1 more source

Newly Identified Roles for PIEZO1 Mechanosensor in Controlling Normal Megakaryocyte Development and in Primary Myelofibrosis [PDF]

, 2023
Iris Karkempetzaki, Vittorio Abbonante, Catherine Léon, Nasi Huang, Christian A. Di Buduo, Daniele Cattaneo, Christina M. Ward, Shinobu Matsuura, Alessandra Iurlo, Alessandra Balduini, Katya Ravid   +10 more
openalex   +1 more source

Pacifica: A Randomized, Controlled Phase 3 Study of Pacritinib Vs. Physician's Choice in Patients with Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post Essential Thrombocytopenia Myelofibrosis with Severe Thrombocytopenia (Platelet Count <50,000/mL)

Blood, 2019
Background: Myelofibrosis (MF) is a life-limiting condition with severe morbidity in advanced stages. Patients with MF and severe thrombocytopenia (platelet counts
C. Harrison, A. Gerds, J. Kiladjian, K. Döhner, S. Buckley, Jennifer A. Smith, A. Craig, J. Mascarenhas, S. Verstovsek   +8 more
semanticscholar   +1 more source

Ruxolitinib Treatment in a Patient with Primary Myelofibrosis Resistant to Conventional Therapies and Splenectomy: A Case Report

Turkish Journal of Hematology, 2015
A 67-year-old male patient who was diagnosed with primary myelofibrosis 4 years ago did not respond to conventional therapies. The splenomegaly progressively increased, which caused spleen infarctions and led to the decision to perform a splenectomy ...
Meltem Aylı, Muhit Özcan, Güldane Cengiz Seval   +2 more
doaj   +1 more source