Results 141 to 150 of about 4,938,261 (300)
Deregulated JAK/STAT signalling in lymphomagenesis, and its implications for the development of new targeted therapies [PDF]
, 2015 Gene expression profiling has implicated several intracellular signalling cascades, including the JAK/STAT pathway, in the pathogenesis of particular subtypes of lymphoma.
Gandhi, Maher K., Scott, Linda M.
core +1 more source
eJHaem, Volume 6, Issue 6, December 2025.ABSTRACT Introduction Ruxolitinib is a key therapeutic option for patients with myeloproliferative neoplasms. Its short‐term toxicity profile is well‐established, but long‐term safety data remains scarce. Methods We aimed to evaluate toxicity associated with long‐term exposure to ruxolitinib (defined as 3 years or longer) through a dual‐cohort ...
Alberto Blanco‐Sánchez +8 more
wiley +1 more source
Turkish Journal of Hematology, 2015 A 67-year-old male patient who was diagnosed with primary myelofibrosis 4 years ago did not respond to conventional therapies. The splenomegaly progressively increased, which caused spleen infarctions and led to the decision to perform a splenectomy ...
Meltem Aylı +2 more
doaj +1 more source
Clonal heterogeneity as a driver of disease variability in the evolution of myeloproliferative neoplasms. [PDF]
, 2014 Myeloproliferative neoplasms (MPNs) are clonal hematological diseases in which cells of the myelo-erythroid lineage are overproduced and patients are predisposed to leukemic transformation.
de Haan, Gerald +3 more
core +1 more source
Rare congenital chromosomal aberration dic(X;Y)(p22.33;p11.32) in a patient with primary myelofibrosis [PDF]
, 2016 Lenka Pavlištová +6 more
openalex +1 more source
Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis
Journal of Experimental Medicine, 2016 Estrov and collaborators examine the role of fibrocytes in primary myelofibrosis and propose a novel therapeutic approach.
S. Verstovsek +17 more
semanticscholar +1 more source
Novel Nonsense Mutation in SMARCD2 Gene Results in Dysplasia of All Myeloid Cell Lines
eJHaem, Volume 6, Issue 6, December 2025.ABSTRACT Introduction Specific granule deficiency type II (SGD2) is a rare heterogeneous congenital disease characterized by early‐onset life‐threatening infections. SGD2 is caused by autosomal recessive mutations in the SMARCD2 gene. Methods Prenatal screening in our patient revealed a novel homozygous nonsense mutation in SMARCD2 (c.208C>T, p.Gln70*).
Michelle A. E. Brouwer +6 more
wiley +1 more source
Development of Dermatomyositis in a Patient with Primary Myelofibrosis
Hematology, 2001 It is known that immunologic mechanisms play an important role in the disease process of some patients with idiopathic myelofibrosis. Patients with idiopathic myelofibrosis have an increased incidence of autoantibodies and circulating immune complexes.
TAŞKAPAN, HÜLYA +4 more
openaire +3 more sources
eJHaem, Volume 6, Issue 6, December 2025.ABSTRACT Background Aquagenic pruritus (AP) is a common and distressing symptom in myeloproliferative neoplasm (MPN) patients. Methods This study assessed cytoreductive therapy effectiveness using data from 489 patients in the OBENE Observatory (NCT02897297). AP severity was tracked regularly after diagnosis.
Christelle Le Gall‐Ianotto +8 more
wiley +1 more source