Results 21 to 30 of about 4,811,177 (246)

Coexistence of primary myelofibrosis and chronic lymphocytic leukemia

Blood and Lymphatic Cancer: Targets and Therapy, 2014
Sonja Burgstaller, Josef Thaler Klinikum Wels-Grieskirchen, Abteilung für Innere Medizin IV, Wels, AustriaAbstract: Coexistence of two hematologic malignancies in one patient is generally a rare phenomenon.
Burgstaller S, Thaler J
doaj   +2 more sources

Pathophysiology of and Therapy for Primary Myelofibrosis

Nihon Naika Gakkai Zasshi, 2007
Kazuya Shimoda
openalex   +4 more sources

Primary myelofibrosis: 2023 update on diagnosis, risk‐stratification, and management

American journal of hematology/oncology, 2023
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell‐derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR, or MPL mutations; additional features include bone marrow reticulin ...
A. Tefferi
semanticscholar   +1 more source

Higher estimated plasma volume status is associated with increased thrombotic risk and impaired survival in patients with primary myelofibrosis

Biochemia Medica, 2023
Introduction Blood plasma represents a large reservoir of cytokines and other mediators of inflammation. Higher estimated plasma volume status (ePVS) has been shown to correlate with increased thrombotic risk in polycythemia vera patients, but its ...
M. Lucijanić, I. Krečak, E. Sorić, A. Sabljić, D. Galušić, H. Holik, V. Periša, Martina Morić Perić, I. Zekanović, R. Kušec   +9 more
semanticscholar   +1 more source

Differential prognostic impact of cytopenic phenotype in prefibrotic vs overt primary myelofibrosis

Blood Cancer Journal, 2022
Dear Editor , Cytopenias are frequent and distinctive features of primary myelo fi brosis (PMF). Anemia is the most common, has consistently been associated with shortened survival, and is an integral component of prognostic models (IPSS, DIPSS/-plus ...
G. Coltro, F. Mannelli, G. G. Loscocco, C. Mannarelli, G. Rotunno, C. Maccari, Fabiana Pancani, A. Atanasio, A. Vannucchi, P. Guglielmelli   +9 more
semanticscholar   +1 more source

Therapeutic activity of GARP:TGF-β1 blockade in murine primary myelofibrosis

Blood, 2022
Key Points • Anti-GARP:TGF-β1 mAb exerts antitumor activity in myeloproliferative neoplasms by selectively blocking Treg-derived TGF-β1.• Targeting Treg functions is feasible and has immune-mediated therapeutic activity in blood cancers.
S. Lecomte, Devreux Julien, Grégoire de Streel, N. van Baren, D. Schröder, Noora Vaherto, Christophe Vanhaver, Christophe Vanderaa, Noémie Dupuis, C. Pecquet, P. Coulie, S. Constantinescu, S. Lucas   +12 more
semanticscholar   +1 more source

IGFBP-6/sonic hedgehog/TLR4 signalling axis drives bone marrow fibrotic transformation in primary myelofibrosis

Aging, 2021
Primary myelofibrosis is a Ph-negative chronic myeloproliferative neoplasm characterized by bone marrow fibrosis and associated with the involvement of several pathways, in addition to bone marrow microenvironment alterations, mostly driven by the ...
L. Longhitano, D. Tibullo, N. Vicario, C. Giallongo, E. La Spina, A. Romano, S. Lombardo, M. Moretti, Francesco Masia, A. R. Coda, S. Venuto, Paolo Fontana, R. Parenti, G. Li Volti, M. Di Rosa, G. Palumbo, A. Liso   +16 more
semanticscholar   +1 more source

Primary Myelofibrosis

Handbook of Hematologic Malignancies, 2020
Initially, most people with primary myelofibrosis have no signs or symptoms. Eventually, fibrosis can lead to a reduction in the number of red blood cells, white blood cells, and platelets.
Carmelo J. Blanquicett, Andrew Kuykendall   +1 more
semanticscholar   +2 more sources

Impact of the rs1024611 Polymorphism of CCL2 on the Pathophysiology and Outcome of Primary Myelofibrosis

Cancers, 2021
Simple Summary Among myeloproliferative neoplasms, primary myelofibrosis (PMF) is considered the paradigm of inflammation-related cancer development. Host genetic variants such as single nucleotide polymorphisms (SNPs) can affect cytokine/chemokine gene ...
E. Masselli, C. Carubbi, Giulia Pozzi, A. Percesepe, R. Campanelli, L. Villani, G. Gobbi, S. Bonomini, G. Roti, V. Rosti, M. Massa, G. Barosi, M. Vitale   +12 more
semanticscholar   +1 more source

Disseminated tuberculosis with myelofibrosis presentation: a case report

Journal of Medical Case Reports, 2021
Background Primary myelofibrosis is a rare myeloproliferative disorder in middle-aged and old adults and should be distinguished from secondary and reactive causes of bone marrow fibrosis because, in reactive fibrosis, treatment approaches depend on the ...
Mahdi Khatuni, Marziyeh Ghalamkari, Fereshteh Ameli, Habibeh Yekehtaz   +3 more
doaj   +1 more source