Results 71 to 80 of about 4,811,177 (246)

Philadelphia-negative myeloproliferative neoplasms as disorders marked by cytokine modulation

Hematology, Transfusion and Cell Therapy, 2018
Background: Cytokines are key immune mediators in physiological and disease processes, whose increased levels have been associated with the physiopathology of hematopoietic malignancies, such as myeloproliferative neoplasms.
Maira da Costa Cacemiro, Juçara Gastaldi Cominal, Raquel Tognon, Natalia de Souza Nunes, Belinda Pinto Simões, Lorena Lôbo de Figueiredo-Pontes, Luiz Fernando Bazzo Catto, Fabíola Traina, Elizabeth Xisto Souto, Fabiana Albani Zambuzi, Fabiani Gai Frantz, Fabíola Attié de Castro   +11 more
doaj   +1 more source

CALR Type 1‐Like Mutations Increase Endoplasmic Reticulum Free Ca2+ and Induce ERK1/2 Activation Independent of Thrombopoietin Receptor Activation

Cell Biology International, EarlyView.
ABSTRACT Calreticulin is a multifunctional protein found in the endoplasmic reticulum lumen that is important for calcium homeostasis and glycoprotein folding. Mutations in exon 9 of the CALR gene are the second most common genetic cause of myeloproliferative neoplasms.
Mifra Faiz, Caitlin Dunstan‐Harrison, Elizabeth C. Ledgerwood   +2 more
wiley   +1 more source

Revised cytogenetic risk stratification in primary myelofibrosis: analysis based on 1002 informative patients

Leukemia, 2018
Current cytogenetic risk stratification in primary myelofibrosis (PMF) is two-tiered: ‘favorable’ and ‘unfavorable’. Recent studies have suggested prognostic heterogeneity within the unfavorable risk category.
A. Tefferi, M. Nicolosi, M. Mudireddy, T. Lasho, N. Gangat, K. Begna, C. Hanson, R. Ketterling, A. Pardanani   +8 more
semanticscholar   +1 more source

Analysis of MicroRNA -155-5p Expression in Patients with Primary Myelofibrosis.

مجلة كلية الطب
Background: Primary myelofibrosis is a chronic myeloproliferative neoplasm characterized by abnormal megakaryocyte proliferation and fibrosis that destroys healthy bone marrow.
Sarah I. Khaleel, Jaffar N. AlAlsaidissa   +1 more
doaj   +1 more source

Transition Metal‐Free Ortho‐Deuteration of Electron‐Deficient N‐Heteroarenes

European Journal of Organic Chemistry, EarlyView.
Herin, the metal‐free, selective deuteration of electron‐deficient N‐heteroaromatics is reported using O‐carbamate and carboxamide ortho‐directing groups (DGs), lithium 2,2,6,6‐tetramethylpiperidide as the base, and D2O as a green source of D+. The substrate scope includes 10 small molecule N‐heteroaromatic compounds and two pharmaceutically relevant ...
Žiga Oražem, Luka Jedlovčnik, Jernej Birk, Andrej Pevec, Ross D. Jansen‐van Vuuren, Janez Košmrlj   +5 more
wiley   +1 more source

The role of the extracellular matrix in primary myelofibrosis [PDF]

Blood Cancer Journal, 2017
AbstractPrimary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) fibrosis. While cellular mutations involved in the development of PMF have been heavily investigated, noteworthy is the important role the extracellular matrix (ECM) plays in ...
Alessandra Balduini, S Chitalia, Shinobu Matsuura, Orly Leiva, Katya Ravid, Seng Kah Ng   +5 more
openaire   +2 more sources

CD133 marks a stem cell population that drives human primary myelofibrosis

Haematologica, 2015
Primary myelofibrosis is a myeloproliferative neoplasm characterized by bone marrow fibrosis, megakaryocyte atypia, extramedullary hematopoiesis, and transformation to acute myeloid leukemia.
Ioanna Triviai, Thomas Stübig, Birte Niebuhr, Kais Hussein, Asterios Tsiftsoglou, Boris Fehse, Carol Stocking, Nicolaus Kröger   +7 more
doaj   +1 more source

CD146+ bone marrow osteoprogenitors increase in the advanced stages of primary myelofibrosis

Haematologica, 2009
CD146+ bone marrow stromal cells have been recently recognized as clonogenic osteoprogenitors able to organize a complete hematopoietic microenvironment.
Claudio Tripodo, Andrea Di Bernardo, Maria Paola Ternullo, Carla Guarnotta, Rossana Porcasi, Sabrina Ingrao, Umberto Gianelli, Emanuela Boveri, Emilio Iannitto, Giovanni Franco, Ada Maria Florena   +10 more
doaj   +1 more source

Therapeutic targeting of chromatin alterations in leukemia and solid tumors

International Journal of Cancer, EarlyView.
Abstract Alterations in chromatin conformation and post‐translational modification of histones have become increasingly recognized as critical drivers of cancer development, progression, and therapy resistance. Recent advances in drug development have led to the establishment of several highly selective small molecule inhibitors, several of which are ...
Florian Perner, Tobias Berg, Daniel Sasca, Sophie‐Luise Mersiowsky, Jayant Y. Gadrey, Johanna Thomas, Michael W. M. Kühn, Michael Lübbert   +7 more
wiley   +1 more source

Non-driver mutations in myeloproliferative neoplasm-associated myelofibrosis

Journal of Hematology & Oncology, 2017
We studied non-driver mutations in 62 subjects with myeloproliferative neoplasm (MPN)-associated myelofibrosis upon diagnosis, including 45 subjects with primary myelofibrosis (PMF) and 17 with post-polycythemia vera or post-essential thrombocythemia ...
Bing Li, Robert Peter Gale, Zefeng Xu, Tiejun Qin, Zhen Song, Peihong Zhang, Jie Bai, Lei Zhang, Yue Zhang, Jinqin Liu, Gang Huang, Zhijian Xiao   +11 more
doaj   +1 more source