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Primary and persistent negative symptoms: Concepts, assessments and neurobiological bases [PDF]
Schizophrenia Research, 2017 Primary and persistent negative symptoms (PPNS) represent an unmet need in the care of people with schizophrenia. They have an unfavourable impact on real-life functioning and do not respond to available treatments. Underlying etiopathogenetic mechanisms of PPNS are still unknown.
André Aleman +2 more
exaly +6 more sources
The emergence of primary negative symptoms: relevance of timing?
The British Journal of Psychiatry, 2023 Negative symptoms are an important symptom dimension in schizophrenia that are often least responsive to antipsychotic medications. We revisit the current practice of identifying ‘primary’ negative symptoms and suggest that its concept would benefit from a further elaboration of their timing of emergence in relation to the dynamic neurobiological ...
Eric Yu Hai Chen +4 more
openaire +3 more sources
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Pharmacological treatment of primary negative symptoms in schizophrenia: A systematic review
Schizophrenia Research, 2006Optimal treatment of primary negative symptoms is important because their presence is associated with poor outcome.To systematically review all studies dealing with the efficacy of pharmacological agents on primary negative symptoms.A comprehensive search of the relevant literature was undertaken using electronic database, reference lists and personal ...
Tae Won Park +2 more
exaly +3 more sources
Subtypes of negative symptoms: The primary subtype in schizophrenic and non-schizophrenic patients
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 19941. The specificity of negative symptoms remains an open question and requires further research. 2. Subtyping negative symptoms has been showed to be a very relevant point for the identification of primary negative symptoms and for their pharmacotherapy. Negative symptoms as a whole have been demonstrated in schizophrenic and non-schizophrenic patients,
H Gerbaldo, O Benkert, Michael Philipp
exaly +3 more sources
Psychiatry Research, 2005
Frontal cognitive inabilities have been amply described in schizophrenic patients with negative symptoms, but findings are controversial. These discrepancies could be due to the fact that negative symptoms are heterogeneous, composed of primary and secondary negative symptoms.
Remy Morello +2 more
exaly +4 more sources
Frontal cognitive inabilities have been amply described in schizophrenic patients with negative symptoms, but findings are controversial. These discrepancies could be due to the fact that negative symptoms are heterogeneous, composed of primary and secondary negative symptoms.
Remy Morello +2 more
exaly +4 more sources
Premorbid, clinical and cognitive correlates of primary negative symptoms in first-episode psychosis
Psychiatry Research, 2016Negative symptoms are a core psychopathological dimension of psychotic disorders. Previous research on primary negative symptoms (PNS) mostly focused on chronic samples. Data regarding premorbid, clinical and cognitive correlates of PNS in the early illness course are limited and inconsistent.
Christy L M Hui +2 more
exaly +6 more sources
Ischemic stroke as a primary symptom of neurosyphilis among HIV-negative emergency patients
Journal of the Neurological Sciences, 2012Neurosyphilis is known as "the great imitator" or "the great impostor" because of its wide range of clinical symptoms. A high misdiagnosis rate of ischemic stroke was observed among neurosyphilis patients in clinical practice, which prevents patients from receiving the most appropriate treatment, and often results in more severe neurologic damage.A ...
Tian-ci Yang, Li-Rong Lin, Li-Li Liu
exaly +4 more sources
Human Psychopharmacology, 2006
Negative symptoms are debilitating and associated with poor role functioning and reduced quality of life. There is a paucity of research on antipsychotic efficacy against the primary negative symptoms, particularly in first-episode psychosis (FEP). We undertook a prospective, open-label pilot trial to investigate the use of amisulpride in the treatment
Patrick McGorry +2 more
exaly +3 more sources
Negative symptoms are debilitating and associated with poor role functioning and reduced quality of life. There is a paucity of research on antipsychotic efficacy against the primary negative symptoms, particularly in first-episode psychosis (FEP). We undertook a prospective, open-label pilot trial to investigate the use of amisulpride in the treatment
Patrick McGorry +2 more
exaly +3 more sources
Schizophrenia, primary negative symptoms, and soft outcomes in psychiatry
Lancet, The, 2017Stefan Leucht, John M. Davis
exaly +3 more sources