Results 81 to 90 of about 10,329,681 (281)

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Persistent negative symptoms in schizophrenia: an overview [PDF]

, 2007
Persistent negative symptoms represent an alternative ap-proach for assessing negative symptoms in the context of clinical trials. Persistent negative symptoms are designed to capture those symptoms that lead to functional impair-ment but are currently ...
Robert W. Buchanan, Robert W Buchanan
core  

Negative symptoms of schizophrenia: new developments and unanswered research questions

, 2018
Negative symptoms of schizophrenia are associated with poor functional outcome and place a substantial burden on people with this disorder, their families, and health-care systems. We summarise the evolution of the conceptualisation of negative symptoms,
Armida Mucci, Arango, Celso, Galderisi, Silvana, Buchanan, Robert W, Celso Arango, Mucci, Armida, Silvana Galderisi, Robert W Buchanan   +7 more
core   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Neurobiological background of negative symptoms

, 2015
Studies investigating neurobiological bases of negative symptoms of schizophrenia failed to provide consistent findings, possibly due to the heterogeneity of this psychopathological construct.
MUCCI, Armida, MERLOTTI, Eleonora, GALDERISI, Silvana   +2 more
core   +1 more source

Relationship Between Cognition and Primary Negative Symptoms Sub-domains in Schizophrenia

European Psychiatry, 2017
IntroductionThe relationship between negative symptoms and cognition in schizophrenia is not clear, a number of authors whom studied this relationship came up with inconsistent findings and meta-analyses show that there is a small moderate associations between the two domains.Objectives and aimsThe aim of this study was to investigate the relationship ...
O.O. Capatina, I.V. miclutia, A. toma
openaire   +2 more sources

Exploring the relationship between mental health status and life events in children and adolescents: the role of mediating factors

Frontiers in Psychiatry
BackgroundThe mental health status of children and adolescents is significantly influenced by negative life events, yet there is a lack of comprehensive analysis on mediating factors.
Jiemei Xie, Jiemei Xie, Guoqiang Cheng, Mingliang Zhou, Qisheng Liang, Qianjin Wang, Qianjin Wang, Qianjin Wang   +7 more
doaj   +1 more source

Understanding and Mitigating the Risk of Accelerated Biological Aging in Survivors of Cancer: A Scoping Review

Aging and Cancer, EarlyView.
Cancer treatment is associated with measurable acceleration of biological aging across epigenetic, telomere, senescence, and immune biomarkers. However, biomarker validation and interventional strategies remain limited, especially in hematologic malignancies, underscoring the need for standardized multi‐omic aging assessments and adequately powered ...
Moataz Ellithi, Emily Herdman, Danielle Westmark, Vijaya R. Bhatt   +3 more
wiley   +1 more source