Results 31 to 40 of about 36,695 (249)

Pharmacogenetics of ophthalmic topical β-blockers [PDF]

, 2008
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
Smith, Edward M., Wilke, Russell A., Sidjanin, Duska J., McCarty, Catherine A., Patchett, Richard   +4 more
core   +1 more source

Biomarkers in primary open angle glaucoma

Clinical Chemistry and Laboratory Medicine (CCLM), 2012
AbstractGlaucoma, a leading cause of blindness worldwide, is currently defined as a disturbance of the structural or functional integrity of the optic nerve that causes characteristic atrophic changes in the optic nerve, which may lead to specific visual field defects over time.
Kokotas, H., Kroupis, C., Chiras, D., Grigoriadou, M., Lamnissou, K., Petersen, M.B., Kitsos, G.   +6 more
openaire   +3 more sources

Effect of myricetin on primary open-angle glaucoma [PDF]

Translational Neuroscience, 2018
Abstract Background Primary open angle glaucoma (POAG) is the most common form of glaucoma, with a multifactorial etiology that results in retinal ganglion cell death and loss of vision. In this study, we assessed the effects of myricetin on the trabecular meshwork cells in POAG.
Yang Qing, Li Ying, Luo Lin
openaire   +3 more sources

A cohort study of duplex Doppler examinations of the carotid artery in primary open angle glaucoma

, 2014
Objectives To explore the possibility of pathological change in the common carotid artery at the bifurcation and in the internal carotid artery beyond the bifurcation which could contribute to a reduced diastolic pressure as observed in primary open ...
Aldoori, M. I., Marmion, Vincent J, Stephenson, John, Woodcock, J. P., Aldoori, Munther I, Woodcock, John P, Marmion, V. J.   +6 more
core   +1 more source

5-year outcomes of single iStent (G1) trabecular microbypass implantation with phacoemulsification in moderately advanced primary open angle glaucoma [PDF]

, 2021
Purpose: To evaluate the safety and efficacy of combined phacoemulsification and single iStent (G1) (iStent, Glaukos Corp. San Clemente, USA), implantation in moderately advanced primary open angle glaucoma (POAG) with 5-years follow-up.
Ansari, E.
core   +1 more source

Molecular genetics of primary open-angle glaucoma

Indian Journal of Ophthalmology, 2023
Glaucoma is a series of linked optic diseases resulting in progressive vision loss and total blindness due to the acquired loss of retinal ganglion cells.
Manoj Yadav, Aarti Bhardwaj, Anshu Yadav, Rima Dada, Mukesh Tanwar   +4 more
doaj   +1 more source

OPA1 increases the risk of normal but not high tension glaucoma

, 2010
Background Primary open angle glaucoma is a progressive optic neuropathy characterised by the selective loss of retinal ganglion cells, pathological optic disc cupping and visual field defects.
Griffiths, P. G., Birch, M. K., Andrews, R. M., Chinnery, P. F., Hudson, G., Yu-Wai-Man, P., Stewart, J .D.   +6 more
core   +1 more source

Surveillance for ocular hypertension : an evidence synthesis and economic evaluation [PDF]

, 2012
OBJECTIVES: To determine effective and efficient monitoring criteria for ocular hypertension [raised intraocular pressure (IOP)] through (i) identification and validation of glaucoma risk prediction models; and (ii) development of models to determine ...
Banister, K, Burr, JM, Kotecha, A, Garway-Heath, D., H Lemij, M Ryan, Tuulonen, A., Vale, L., Fraser, C., R Sanders, Crabb, D, Kotecha, A., Cook, J, Y Takwoingi, S Vernon, Takwoingi, Y., Banister, K., Fraser, C, Deeks, J, Sanders, R, A Tuulonen, Cook, J., Hernández, R, Glasziou, P, Tuulonen, A, Lemij, H., Vale, L, Burr, Jennifer Margaret, Elders, A., Burr, J.M., R Asaoka, Takwoingi, Y; id_orcid, Azuara-Blanco, A, P Glasziou, Botello-Pinzon, P, Garway-Heath, D, Ryan, Mandy, Vazquez-Montes, M, Lemij, H, Deeks, J., Takwoingi, Y, D Crabb, Azuara-Blanco, A.; id_orcid, L Vale, A Azuara-Blanco, Perera, R., Ryan, M, van der Schoot, J, Perera, R, Sanders, R., Crabb, D., Elders, A, D Garway-Heath, Ryan, M., R Hernández, K Banister, C Fraser, J Cook, J van der Schoot, Botello-Pinzon, P., A Elders, A Kotecha, Glasziou, P., Azuara-Blanco, A., King, A., J Deeks, JM Burr, A King, Burr, J M, Glasziou, Paul, King, A, Vernon, S, Asaoka, R., Vazquez-Montes, M., van der Schoot, J., Vernon, S., M Vazquez-Montes, Perera, Rafael, R Perera, Asaoka, R, Hernandez, R., P Botello-Pinzon   +81 more
core   +1 more source

Hospitalization characteristics of patients with glaucoma in Central and West Serbia [PDF]

Srpski Arhiv za Celokupno Lekarstvo, 2019
Introduction/Objective. Glaucoma is a chronic disease that impairs the optic nerve irreversibly and can lead to serious loss of vision and blindness. As the most frequent out of all, primary open-angle glaucoma has a worldwide incidence of 2.4 million ...
Kocić Sanja, Radević Svetlana, Simić-Vukomanović Ivana, Janićijević Katarina, Janićijević-Petrović Mirjana, Mihailović Nataša   +5 more
doaj   +1 more source

A Viscous DES‐AAV‐Foxo1 Delivery System With High Transfection Efficiency for the Treatment of Corneal Endothelial Dysfunction by Restoring Mitochondria‐ER Contacts

Advanced Science, EarlyView.
High glucose triggers corneal endothelial dysfunction by impairing FOXO1‐mediated ITPR1 transcription, leading to disrupted mitochondria‐associated membrane (MAM) integrity and defective ER‐to‐mitochondria Ca2+ transfer. This study develops an innovative viscous DES‐AAV‐Foxo1 delivery system with enhanced transfection efficiency. This non‐invasive gene
Hongran Zhao, Xiaoyu Li, Hongwei Wang, Zongyi Li, Qun Wang, Yangyang Zhang, Xu Jing, Xia Qi, Qingjun Zhou, Shengqian Dou, Lixin Xie   +10 more
wiley   +1 more source