Results 151 to 160 of about 114,971 (282)

Nanomotor-Driven Extracellular Vesicles With Effective Tissue Penetration for Targeted Therapy of Primary Ovarian Insufficiency. [PDF]

J Extracell Vesicles
Mu Y, Wu J, Lv M, Zhang X, Song Y, Ai J, Ma D, Li K.   +7 more
europepmc   +1 more source

Age, embryo donor status, and insemination with chilled semen all predispose to persistent breeding‐induced endometritis in warmblood mares

Equine Veterinary Journal, EarlyView.
Abstract Background Persistent breeding‐induced endometritis (PBIE) is a common reason for mares failing to establish pregnancy. Objective To examine the hypothesis that advancing mare age and embryo donor status predispose to PBIE and compromise fertility.
Tom Stout, Rik Serrarens, Bart Leemans, Anthony Claes   +3 more
wiley   +1 more source

Diagnostic accuracy of AMH for primary ovarian insufficiency/premature ovarian failure: a real-world cohort study. [PDF]

Front Endocrinol (Lausanne)
Mao S, Yang D, Wang X, Cao X.
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

A TAp63alpha truncating variant associated with primary ovarian insufficiency lowers the cellular apoptotic rate. [PDF]

J Ovarian Res
Moleri S, Casafina S, Borghi MO, Persani L, Rossetti R.   +4 more
europepmc   +1 more source

Heterozygous TP63 pathogenic variants in isolated primary ovarian insufficiency

Journal of Assisted Reproduction and Genetics, 2023
Rachel K Vanderschelden, Marta Rodríguez-Escribà, Serena Chan, A. Berman, A. Rajkovic, S. Yatsenko   +5 more
semanticscholar   +1 more source

Living at genetic risk: The patient experience of Lynch syndrome

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome is a germline cancer predisposition syndrome caused by a variant in one of four genes. Lynch syndrome places individuals at significantly higher risk for a range of cancers, especially colorectal and endometrial. Depending on which gene is affected, the risk of ovarian, gastric, small bowel, pancreatic, biliary urothelial, brain,
Nicola Reents, Georgina Hoffmann, Kelly Kohut   +2 more
wiley   +1 more source

A multilevel perspective on MSH6‐associated Lynch syndrome: Integrating molecular, biological, and clinical insights

International Journal of Cancer, EarlyView.
Abstract Lynch syndrome (LS) is the most common hereditary colorectal cancer syndrome, caused by a germline pathogenic variant in one of the mismatch repair (MMR) genes. Among these, MSH6‐associated LS represents a distinct subtype with unique molecular and clinical characteristics.
Salwa Ben Yahia, Anne‐Sophie van der Werf‐'t Lam, Madalina Cabuta, Maartje Nielsen, Noah C. Helderman   +4 more
wiley   +1 more source

Metabolome analysis identified exogenous cholesterol within lipid rafts that activate the Akt/mTOR signaling pathway in epithelial ovarian cancer

International Journal of Cancer, EarlyView.
What's New? Epithelial ovarian cancer (EOC) is a severe malignancy with few effective treatment options. While the mechanisms remain unclear, changes in lipid metabolism may fuel tumor growth and EOC progression, offering a possible path for new treatments.
Hitomi Sakaguchi‐Mukaida, Kosuke Hiramatsu, Tatsuo Masuda, Mamoru Kakuda, Satoshi Nakagawa, Tadashi Iwamiya, Shinya Matsuzaki, Tetsuji Naka, Yutaka Ueda, Tadashi Kimura, Michiko Kodama   +10 more
wiley   +1 more source

An Evidence-Based Approach to the Management of Primary Ovarian Insufficiency in Adolescents and Young Women. [PDF]

Life (Basel)
Bakhsh H.
europepmc   +1 more source