Results 141 to 150 of about 1,384,720 (238)

Effectiveness of digital health interventions in influencing the primary prevention of non-communicable diseases: protocol for an umbrella review. [PDF]

BMJ Open
Jeleff M, Dorner TE, Ban M, Schön M, Lischka C, Lichtenegger K, Dür M, Hochwarter S, Feichtner F, Haider S.   +9 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Use of Lipid-Lowering Treatment in Primary Prevention in Spain (Lipidspain). [PDF]

J Clin Med
García-Villarino M, Lozano-Aida C, Suárez-Gutiérrez L, Lambert C, González-Vidal T, García AV, Pujante P, Villa-Fernández E, Delgado-Álvarez E, Menéndez-Torre E, Ares-Blanco J.   +10 more
europepmc   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Utilizing existing test results to improve primary prevention in patients with subclinical coronary atherosclerosis: The USE-IT study. [PDF]

Am J Prev Cardiol
Iwanowski M, Pappalettere CC, Vime-Jubany J, Velescu A, Marcos L, Chalela R, Zuccarino F, Maiques JM, Tizon-Marcos H, Vaquerizo-Montilla B, Ruiz-Bustillo S, Casteigt B, Rodriguez N, Rodriguez-Chiaradia D, Marrugat J, Cainzos-Achirica M.   +15 more
europepmc   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Comment on "2024 Guidelines of the Taiwan Society of Cardiology on the Primary Prevention of Atherosclerotic Cardiovascular Disease". [PDF]

Acta Cardiol Sin
Chiang WT, Lee BJ.
europepmc   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Quality indicators for lifestyle or behavioural management for the primary prevention of cardiovascular disease in primary care: a systematic review. [PDF]

BJGP Open
Bam K, Lin B, Olaiya MT, Cadilhac DA, Redfern J, Nelson MR, Sanders LM, Andrew NE, Sundararajan V, Murphy L, Kilkenny MF.   +10 more
europepmc   +1 more source