Results 51 to 60 of about 1,384,720 (238)

Electronic cigarette for smoking cessation: a fast-track Delphi consensus of French-speaking experts

open access: yesArchives of Public Health
Background The French-speaking Society for Smoking Cessation (Société francophone de tabacologie, SFT), which promotes scientific knowledge and training on smoking cessation, asked us to identify and quantify consensual agreements among its members on ...
Emmanuelle Lüthi   +6 more
doaj   +1 more source

Digital interventions in smoking cessation – a brief overview of systematic reviews and meta-analyses

open access: yesNowotwory
Digital health includes a variety of modern methods that may support smoking cessation. In light of increasing interest in digital health interventions and the widespread digitizaton of the digitalization process in Europe, it seems relevant to assess ...
Elwira Gliwska, Marta Mańczuk
doaj   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

open access: yesFEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

open access: yesFEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Early administration of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in patients with acute coronary syndrome: a systematic review and meta-analysis

open access: yesBMC Cardiovascular Disorders
Background High-intensity statin therapy is currently recommended initial guideline therapy in ACS treatment. However, only a minority of patients are achieving LDL-C attainment goal at 6 months.
Kaveh Hosseini   +6 more
doaj   +1 more source

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

open access: yeseLife, 2014
Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in
Jan Sundquist   +2 more
doaj   +1 more source

Caesarean delivery in a migration context: the role of prior delivery in the host country

open access: yesSexual and Reproductive Health Matters, 2020
Migrant women in industrialised countries experience high caesarean section (CS) rates but little is known about the effect of a previous delivery in the host country.
Lorraine Poncet   +3 more
doaj   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

A multi-stage approach to support timely health policy decisions during crisis: the fast-track Delphi

open access: yesBMC Public Health
Background Scientists can play an important role in policymaking by providing evidence and consensual expert opinion on the state of scientific knowledge.
Camille Velarde Crézé   +5 more
doaj   +1 more source

Integrating smoking cessation counseling into oncology practice — benefits and barriers

open access: yesNowotwory
Exposure to tobacco smoke, which contains around 70 carcinogenic components, leads to approximately 8 million deaths worldwide annually. Poland ranks among the top countries with the highest tobacco-related DALY (Disability-Adjusted Life Years) rates ...
Magdalena Cedzyńska   +1 more
doaj   +1 more source

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