Results 71 to 80 of about 7,096,949 (304)

Estimating health service utilization potential using the supply-concentric demand-accumulation spatial availability index: a pulmonary rehabilitation case study

International Journal of Health Geographics, 2020
The potential for a population at a given location to utilize a health service can be estimated using a newly developed measure called the supply-concentric demand accumulation (SCDA) spatial availability index.
Kevin A. Matthews, Anne H. Gaglioti, James B. Holt, Anne G. Wheaton, Janet B. Croft   +4 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Efficacy of motivating short interventions for smokers in primary care (COSMOS trial): study protocol for a cluster-RCT

Trials, 2019
Background Tobacco abuse is a frequent issue in general practitioners' (GPs') offices, with doctors playing a key role in promoting smoking cessation to their patients. However, not all smokers are ready and willing to give up smoking.
Thomas Grischott, Oliver Senn, Thomas Rosemann, Anja Frei, Jacques Cornuz, Eva Martin-Diener, Stefan Neuner-Jehle   +6 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Killinarden Drug Primary Prevention Group: project report. [PDF]

, 2000
The Killinarden Drug Primary Prevention Group (KDPPG) has been operational in Killinarden, west Tallaght since 1993. The project receives funding from Tallaght Drugs Task Force.

core  

Electronic cigarette for smoking cessation: a fast-track Delphi consensus of French-speaking experts

Archives of Public Health
Background The French-speaking Society for Smoking Cessation (Société francophone de tabacologie, SFT), which promotes scientific knowledge and training on smoking cessation, asked us to identify and quantify consensual agreements among its members on ...
Emmanuelle Lüthi, Camille Velarde Crézé, Luc Lebon, Isabelle Jacot-Sadowski, Karin Zürcher, Jacques Cornuz, Olivier Duperrex   +6 more
doaj   +1 more source

Digital interventions in smoking cessation – a brief overview of systematic reviews and meta-analyses

Nowotwory
Digital health includes a variety of modern methods that may support smoking cessation. In light of increasing interest in digital health interventions and the widespread digitizaton of the digitalization process in Europe, it seems relevant to assess ...
Elwira Gliwska, Marta Mańczuk
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Comparing primary prevention with secondary prevention to explain decreasing Coronary Heart Disease death rates in Ireland, 1985-2000. [PDF]

, 2007
BACKGROUND: To investigate whether primary prevention might be more favourable than secondary prevention (risk factor reduction in patients with coronary heart disease(CHD)).
Kabir Z, Julia A Critchley, Unal B, Unal, B, Shelley E, Capewell, S, Kabir, Zubair, Unal, Belgin, Kabir Zubair, Kathleen Bennett, Critchley, Julia A, Critchley, Julia A., Critchley Julia A, Belgin Unal, Kabir, Z, Shelley Emer, Bennett, Kathleen, Emer Shelley, Capewell S, Critchley, JA, Zubair Kabir, Shelley, E, Unal Belgin, Simon Capewell, Bennett Kathleen, Bennett K, Shelley, Emer, Critchley JA, Capewell Simon, Capewell, Simon, Bennett, K   +30 more
core   +2 more sources