Results 91 to 100 of about 7,096,949 (304)

Integrating smoking cessation counseling into oncology practice — benefits and barriers

Nowotwory
Exposure to tobacco smoke, which contains around 70 carcinogenic components, leads to approximately 8 million deaths worldwide annually. Poland ranks among the top countries with the highest tobacco-related DALY (Disability-Adjusted Life Years) rates ...
Magdalena Cedzyńska, Irena A. Przepiórka   +1 more
doaj   +1 more source

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

eLife, 2014
Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in
Jan Sundquist, Kristina Sundquist, Jianguang Ji   +2 more
doaj   +1 more source

Caesarean delivery in a migration context: the role of prior delivery in the host country

Sexual and Reproductive Health Matters, 2020
Migrant women in industrialised countries experience high caesarean section (CS) rates but little is known about the effect of a previous delivery in the host country.
Lorraine Poncet, Henri Panjo, Armelle Andro, Virginie Ringa   +3 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Primary prevention of skin cancer in primary care settings - A scoping review

, 2022
Background: Skin cancer is highly preventable through primary prevention activities such as avoiding UV exposure during peak times and regular use of sun protection.
Dunlop, Kate, Singh, Nehal, Smit, Amelia K, Woolley, Nikki, Cust, Anne E, Damien, Diona L, Vuong, Kylie   +6 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Screening and prevention in Swiss primary care: a systematic review

, 2011
David Eisner, Marco Zoller, Thomas Rosemann, Carola A Huber, Nina Badertscher, Ryan TandjungInstitute for General Practice and Health Services Research, University of Zurich, Zurich, SwitzerlandBackground and objectives: Prevention is a challenging area ...
Huber CA, Tandjung R, Zoller M, Eisner D, Rosemann T, Badertscher N   +5 more
core  

What is the 'problem' that outreach work seeks to address and how might it be tackled? Seeking theory in a primary health prevention programme [PDF]

, 2011
<b>Background</b> Preventive approaches to health are disproportionately accessed by the more affluent and recent health improvement policy advocates the use of targeted preventive primary care to reduce risk factors in poorer individuals and
Mhairi Mackenzie, Mackenzie, M., Wang Yingying, O'Donnell, Catherine, Mackenzie Mhairi, O'Donnell, C.A., Wang, Yingying, Sridharan, Sanjeev, Stephen Platt, Reid Maggie, Yingying Wang, Reid, M., Platt, Stephen, Fiona Turner, Platt Stephen, Clark Julia, Turner, F., O'Donnell, Catherine A, Julia Clark, Mackenzie, Mhairi, Clark, J., O'Donnell Catherine A, Maggie Reid, Sridharan Sanjeev, Clark, Julia, Reid, Maggie, Turner, Fiona, Platt, S., Catherine A O'Donnell, Sridharan, S., Turner Fiona, Wang, Y., O'Donnell, Catherine A., Sanjeev Sridharan   +33 more
core   +2 more sources