Results 81 to 90 of about 7,096,949 (304)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Early administration of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in patients with acute coronary syndrome: a systematic review and meta-analysis

BMC Cardiovascular Disorders
Background High-intensity statin therapy is currently recommended initial guideline therapy in ACS treatment. However, only a minority of patients are achieving LDL-C attainment goal at 6 months.
Kaveh Hosseini, Hamidreza Soleimani, Saba Maleki, Amir Nasrollahizadeh, Sima Tayebi, John Nelson, Sean P. Heffron   +6 more
doaj   +1 more source

How Primary Healthcare Sector is Organized at the Territorial Level in France? A Typology of Territorial Structuring [PDF]

International Journal of Health Policy and Management
Background  Most the Organization for Economic Co-operation and Development (OECD) countries are currently facing the challenges of the health transition, the aging of their populations and the increase in chronic diseases.
Sylvain Gautier, Loïc Josseran
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Public opinion on primary prevention of dementia, multiple sclerosis and Parkinson’s disease [PDF]

This is a policy briefing produced by the NIHR Dementia and Neurodegeneration Policy Research Unit at Queen Mary University of London (DeNPRU-QM). Summary Neurodegenerative diseases such as dementia, multiple sclerosis and Parkinson’s disease are amongst
Marshall, CR, Kenten, C, Carroll on behalf of DeNPRU-QM, C, Browning, S, Pouncey, T, Mukadam, N, Schott, J, Horne, R, Thomson, A, Cooper, C, Carr, G, Rauf, M, Dobson, R, Banerjee, S   +13 more
core   +1 more source

Epidemiology of substance and opium use among adult residents of Tehran; a comprehensive report from Tehran cohort study (TeCS)

BMC Psychiatry
Background The prevalence and burden of substance and opium use have increased worldwide over the past decades. In light of rapid population changes in Tehran, we aimed to evaluate the prevalence of opium and other substance use among adult residents in ...
Farzad Masoudkabir, Akbar Shafiee, Amirhossein Heidari, Negin Sadat Hosseini Mohammadi, Kiarash Tavakoli, Arash Jalali, Sepehr Nayebirad, Farshid Alaeddini, Soheil Saadat, Ali Vasheghani-Farahani, Saeed Sadeghian, Vicente Artola Arita, Mohamamdali Boroumand, Abbasali Karimi   +13 more
doaj   +1 more source

Harm reduction for smokers — can new nicotine products play a role?

Nowotwory
Harm reduction strategies aim to minimize the health and social consequences of psychoactive substance use. Recently,electronic cigarettes (e-cigarettes) and heated tobacco products have been promoted as “safer” alternativesto conventional cigarettes ...
Irena A. Przepiórka-Rosłońska, Magdalena Cedzyńska   +1 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Introduction to the Special Issue: Measurement and Monitoring Systems and Frameworks for Assessing Implementation and Adaptation of Prevention Programs

, 2019
The current field of prevention science boasts an increasing armamentarium of effective preventive interventions, reflecting the growing promise of the field.
Kerns, Suzanne EU, Bumbarger, Brian K
core   +1 more source

A multi-stage approach to support timely health policy decisions during crisis: the fast-track Delphi

BMC Public Health
Background Scientists can play an important role in policymaking by providing evidence and consensual expert opinion on the state of scientific knowledge.
Camille Velarde Crézé, Olivier Duperrex, Luc Lebon, Vincent Faivre, Myriam Pasche, Jacques Cornuz   +5 more
doaj   +1 more source