Results 51 to 60 of about 1,431,128 (265)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Electronic cigarette for smoking cessation: a fast-track Delphi consensus of French-speaking experts

Archives of Public Health
Background The French-speaking Society for Smoking Cessation (Société francophone de tabacologie, SFT), which promotes scientific knowledge and training on smoking cessation, asked us to identify and quantify consensual agreements among its members on ...
Emmanuelle Lüthi, Camille Velarde Crézé, Luc Lebon, Isabelle Jacot-Sadowski, Karin Zürcher, Jacques Cornuz, Olivier Duperrex   +6 more
doaj   +1 more source

Digital interventions in smoking cessation – a brief overview of systematic reviews and meta-analyses

Nowotwory
Digital health includes a variety of modern methods that may support smoking cessation. In light of increasing interest in digital health interventions and the widespread digitizaton of the digitalization process in Europe, it seems relevant to assess ...
Elwira Gliwska, Marta Mańczuk
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Early administration of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors in patients with acute coronary syndrome: a systematic review and meta-analysis

BMC Cardiovascular Disorders
Background High-intensity statin therapy is currently recommended initial guideline therapy in ACS treatment. However, only a minority of patients are achieving LDL-C attainment goal at 6 months.
Kaveh Hosseini, Hamidreza Soleimani, Saba Maleki, Amir Nasrollahizadeh, Sima Tayebi, John Nelson, Sean P. Heffron   +6 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Epidemiology of substance and opium use among adult residents of Tehran; a comprehensive report from Tehran cohort study (TeCS)

BMC Psychiatry
Background The prevalence and burden of substance and opium use have increased worldwide over the past decades. In light of rapid population changes in Tehran, we aimed to evaluate the prevalence of opium and other substance use among adult residents in ...
Farzad Masoudkabir, Akbar Shafiee, Amirhossein Heidari, Negin Sadat Hosseini Mohammadi, Kiarash Tavakoli, Arash Jalali, Sepehr Nayebirad, Farshid Alaeddini, Soheil Saadat, Ali Vasheghani-Farahani, Saeed Sadeghian, Vicente Artola Arita, Mohamamdali Boroumand, Abbasali Karimi   +13 more
doaj   +1 more source

Harm reduction for smokers — can new nicotine products play a role?

Nowotwory
Harm reduction strategies aim to minimize the health and social consequences of psychoactive substance use. Recently,electronic cigarettes (e-cigarettes) and heated tobacco products have been promoted as “safer” alternativesto conventional cigarettes ...
Irena A. Przepiórka-Rosłońska, Magdalena Cedzyńska   +1 more
doaj   +1 more source

Autism and attention-deficit/hyperactivity disorder among individuals with a family history of alcohol use disorders

eLife, 2014
Recent studies suggest de novo mutations may involve the pathogenesis of autism and attention-deficit/hyperactivity disorder (ADHD). Based on the evidence that excessive alcohol consumption may be associated with an increased rate of de novo mutations in
Jan Sundquist, Kristina Sundquist, Jianguang Ji   +2 more
doaj   +1 more source