Results 71 to 80 of about 129,162 (296)

Data-driven neuroanatomical subtypes of primary progressive aphasia

medRxiv
The primary progressive aphasias are rare, language-led dementias, with three main variants: semantic, non-fluent/agrammatic, and logopenic. Whilst semantic variant has a clear neuroanatomical profile, the non-fluent/agrammatic and logopenic variants are
Beatrice Taylor, M. Bocchetta, Cameron Shand, E. Todd, Anthipa Chokesuwattanaskul, S. Crutch, Jason D. Warren, Jonathan D Rohrer, Chris J D Hardy, Neil P. Oxtoby   +9 more
semanticscholar   +1 more source

Multimodality Imaging in Primary Progressive Aphasia

American Journal of Neuroradiology, 2022
SUMMARY: Primary progressive aphasia is a clinically and neuropathologically heterogeneous group of progressive neurodegenerative disorders, characterized by language-predominant impairment and commonly associated with atrophy of the dominant language ...
M. Roytman, G. Chiang, M. Gordon, A. Franceschi   +3 more
semanticscholar   +1 more source

Non-verbal sound processing in the primary progressive aphasias [PDF]

, 2010
Little is known about the processing of non-verbal sounds in the primary progressive aphasias. Here, we investigated the processing of complex non-verbal sounds in detail, in a consecutive series of 20 patients with primary progressive aphasia [12 with ...
Bamiou, D.-E., Crutch, S. J., Frost, C., Goll, J. C., Loo, J. H. Y., Rohrer, J. D., Warren, J. D.   +6 more
core  

TBK1‐Associated Primary Lateral Sclerosis Followed by Right Temporal Variant Frontotemporal Dementia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT We report a 58‐year‐old woman with a novel splice‐site variant in the TANK‐binding kinase 1 (TBK1:c.993–2A>C p.Ala332TyrfsTer39) who sequentially developed primary lateral sclerosis (PLS) followed by right temporal variant frontotemporal dementia (rtvFTD). Neuroimaging demonstrated right anterior temporal atrophy before cognitive symptoms, and
Tomoyasu Matsubara, Naoki Kihara, Satoko Miyatake, Koji Fujita, Konoka Tachibana, Ryosuke Miyamoto, Hiroki Yamazaki, Yusuke Osaki, Nazere Keyoumu, Yuki Kuwano, Nobutoshi Morimoto, Suzuran Saito, Eriko Koshimizu, Yoichi Otomi, Kenji Ishibashi, Masafumi Harada, Naomichi Matsumoto, Hiroyuki Morino, Yuishin Izumi   +18 more
wiley   +1 more source

Clinicoradiological and neuropathological evaluation of primary progressive aphasia

Journal of Neurology Neurosurgery & Psychiatry
Background Primary progressive aphasia (PPA) defines a group of neurodegenerative disorders characterised by language decline. Three PPA variants correlate with distinct underlying pathologies: semantic variant PPA (svPPA) with transactive response DNA ...
D. Shir, Nick Corriveau-Lecavalier, Camilo Bermudez Noguera, L. Barnard, Nha Trang, Thu Pham, H. Botha, Joseph R. Duffy, Heather M. Clark, Rene L. Utianski, D. Knopman, R. C. Petersen, B. Boeve, M. Murray, A. Nguyen, R. Reichard, Dennis W Dickson, G. Day, Walter K. Kremers, N. Graff-Radford, David T Jones, M. Machulda, Julie A. Fields, J. Whitwell, K. Josephs, J. Graff‐Radford, Twitter Gregory, S. Day   +27 more
semanticscholar   +1 more source

Neologistic jargon aphasia and agraphia in primary progressive aphasia [PDF]

, 2009
The terms 'jargon aphasia' and 'jargon agraphia' describe the production of incomprehensible language containing frequent phonological, semantic or neologistic errors in speech and writing, respectively.
Rohrer, JD, Rossor, MN, Warren, JD
core  

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

Spelling Intervention in Post-Stroke Aphasia and Primary Progressive Aphasia

Behavioural Neurology, 2013
Spelling–a core language skill–is commonly affected in neurological diseases such as stroke and Primary Progressive Aphasia (PPA). We present two case studies of the same spelling therapy (learning of phoneme-to-grapheme correspondences with help from ...
Kyrana Tsapkini, Argye E. Hillis
doaj   +1 more source

Utility of the Addenbrooke’s Cognitive Examination III online calculator to differentiate the primary progressive aphasia variants

Brain Communications, 2022
The Addenbrooke’s Cognitive Examination III is a brief cognitive screening tool that is widely used for the detection and monitoring of dementia. Recent findings suggest that the three variants of primary progressive aphasia can be distinguished based on
D. Foxe, A. Hu, S. Cheung, R. Ahmed, N. Cordato, E. Devenney, Y. Hwang, G. Halliday, N. Mueller, C. Leyton, J. Hodges, J. Burrell, M. Irish, O. Piguet   +13 more
semanticscholar   +1 more source

Progressive Apraxia of Speech: Might There Be Subtypes? [PDF]

, 2013
This study examined speech and language characteristics of three groups of individuals with neurodegenerative disease: (1) primary progressive apraxia of speech (AOS) without aphasia (N=18), (2) agrammatic primary progressive aphasia (agPPA) less severe ...
Duffy, Joseph R., Josephs, Keith A., Strand, Edythe E., Whitwell, Jennifer L.   +3 more
core