Results 91 to 100 of about 10,933,254 (364)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Realizacija m-učenja primjenom BYOD modela u osnovnoj školi
Politehnika, 2019 Mobilno učenje ili m-učenje omogućuje moderan način podrške procesima učenja putem mobilnih uređaja. Jedan od načina realizacije m-učenja je primjena BYOD modela na nastavi, prema kojem učitelji uglavnom iskazuju negativan stav smatrajući da korištenje ...
Tamara Ređep +2 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Planning and Performing Outdoor Living Space Lessons [PDF]
Revija za Elementarno Izobraževanje, 2013 The nature is man’s first teacher. Slovenian people are generally proud of their country being a green oasis in the middle of Europe, characterized by many natural and geographical features.
Fošnarič Samo +2 more
doaj
Health Technology Assessment, 2020 Background: Sciatica has a substantial impact on patients and society. Current care is ‘stepped’, comprising an initial period of simple measures of advice and analgesia, for most patients, commonly followed by physiotherapy, and then by more intensive ...
Nadine E Foster +15 more
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Inquiry-based science education: towards a pedagogical framework for primary school teachers
, 2016 Inquiry-based science education (IBSE) has been promoted as an inspiring way of learning science by engaging pupils in designing and conducting their own scientific investigations.
Martina S. J. van Uum +2 more
semanticscholar +1 more source
PLoS Medicine, 2015 Background Air pollution is a suspected developmental neurotoxicant. Many schools are located in close proximity to busy roads, and traffic air pollution peaks when children are at school. We aimed to assess whether exposure of children in primary school
J. Sunyer +16 more
semanticscholar +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Exploring the relationship between schoolbag weight and back pain in primary school children
Journal of Orthopaedic Surgery and ResearchBackground Schoolbag weight in schoolchildren is a recurrent and contentious issue in education and health. Excessive schoolbag weight can lead to back pain in children, which increases the risk of chronic back pain in adulthood.
Sara Gamareldein Abdalla Khalafalla +6 more
doaj +1 more source