Results 101 to 110 of about 2,015,776 (282)

Good mathematics teaching at lower primary school level

, 2019
This paper explores Norwegian lower primary teachers’ views about good mathematics teaching as revealed in a focus group interview at the end of a two-year school-based professional development program. Analyses of the empirical data indicate three main categories of findings: the teachers’ facilitation of learning, the students’ thinking in and about ...
openaire   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Tutoring and study support for educational success and contrast to the stereotypes. The Sono capace project in the Sinti Village of Tortona (AL)

Educazione Interculturale
The paper presents the experience of the Terre di Mezzo Association in the Sinti Village of Tortona (AL). The project Sono capace has connected a double level: the students of the G.
Andrea Traverso, Giada Finotti
doaj   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Feeding pattern, prevalence of malnutrition and associated determinants amongst primary school children in rural and urban communities of Ekiti State, Southwest Nigeria

Nigerian Postgraduate Medical Journal
Background: Malnutrition is an increasing health problem amongst children, especially in developing countries. This study assessed and compared the feeding pattern, prevalence and determinants of malnutrition amongst primary school children residing in ...
Taofeek Adedayo Sanni, Kayode Rasak Adewoye, Kabir Adekunle Durowade, Olusegun Elijah Elegbede, Tope Michael Ipinnimo, Oluseyi Adedeji Aderinwale   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

School absenteeism data for surveillance purposes: a proxy for acute respiratory infection rates

BMC Public Health
Background School absenteeism data have potential as real-time public health surveillance tool to monitor infectious diseases. This study evaluates the validity and usefulness of school absenteeism data for application in acute respiratory illness (ARI ...
C. M. de Korne, M. Hooiveld, A. J. van Hoek, P. C.J.L Bruijning-Verhagen   +3 more
doaj   +1 more source