Results 111 to 120 of about 323,043 (265)

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

HEALTHY LIFESTYLE: THE ROLE OF EDUCATION IN IMPROVEMENT OF THE KNOWLEDGE OF PRIMARY AND MIDDLE SCHOOL STUDENTS IN ISFAHAN AND NAJAF-ABAD

ARYA Atherosclerosis, 2010
  INTRODUCTION: Lifestyle habits are established from early childhood and persist for many years, almost until the end of life. Thus, healthy lifestyle education should begin in childhood. This study was conducted to train primary and middle school
Mojgan Soghrati, Roya Kelishadi, Rezvan Pashmi, Razieh Omidi   +3 more
doaj  

Infrastructure and Primary School Students

International Journal for Research in Applied Science and Engineering Technology, 2021
openaire   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

How Primary School Students Perceive Primary School Teacher Exchange? [PDF]

Journal of Qualitative Research in Education, 2020
Mustafa Erol, Mustafa Başaran
openaire   +1 more source

Primary School Students' Writing in New Media – A Challenge for School and Students

Školski vjesnik : časopis za pedagogijsku teoriju i praksu, 2019
For some time now we have witnessed the interweaving of speech, writing and picture in the new media communication (Facebook, WhatsApp, etc.). Writing texts in new media often contain elements of oral speech of conversational style, so Crystal (2006) calls them Netspeak.
Turk Sakač, Marija, Filipan - Žignić, Blaženka   +1 more
openaire   +2 more sources

School-based interventions to increase influenza vaccination in primary school students

Vaccine
Addressing low vaccination coverage in primary school students will help prevent influenza outbreaks and safeguard public health. We evaluated the effectiveness of school-based interventions in improving influenza vaccination rates among primary school students in Guizhou, China.Parents and students from four primary schools participated in December ...
Mengmeng, Jia, Yanlin, Cao, Xin, Mu, Dafei, Ren, Jiuquan, Ai, Cai, Yang, Ping, Zhang, Yuxi, Liu, Yuandong, Hu, Luzhao, Feng   +9 more
openaire   +2 more sources

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source