Results 121 to 130 of about 2,288,786 (311)
Studying the Instrument Shelter [PDF]
, 2003 The purpose of this activity is to discover why an instrument shelter is built the way it is. Students construct shelters that have varying properties and place them in the same location or place similar shelters in different locations and compare ...
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
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Survivin and Aurora Kinase A control cell fate decisions during mitosis
Molecular Oncology, EarlyView.Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir +2 more
wiley +1 more source
Phenological Gardens Protocol [PDF]
, 2003 The purpose of this resource is to observe the flowering and leaf stages of selected garden plants throughout the year. After a phenological garden is planted, students observe the growth of leaves and blooming of flowers on the plants. These plants were
The GLOBE Program, University Corporation for Atmospheric Research (UCAR)
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Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
PRIMARY SCHOOL STUDENTS’ LEISURE TIME POSSIBILITIES [PDF]
, 2021 Slobodno vrijeme, kao fenomen, tijekom povijesti se različito shvaćalo. Iako nema jednoznačnu definiciju, ali u ovome radu promatrat će se kao vrijeme kada „mladi nisu formalno angažirani u školskim, kućanskim ili radnim aktivnostima“ (Irby i Tolman 2002 prema Livazović 2019).
openaire
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
Water Temperature Protocol [PDF]
, 2003 The purpose of this resource is to measure the temperature of a water sample. Students use an alcohol-filled thermometer or meter to measure the temperature of water.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
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Molecular Oncology, EarlyView.The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués +3 more
wiley +1 more source
Estimating Cloud Cover - a Simulation [PDF]
, 2003 The purpose of this activity is to help students better understand percent cloud cover and to take more accurate cloud cover observations. Working in pairs or small groups, students use construction paper to simulate cloud cover.
The GLOBE Program, UCAR (University Corporation for Atmospheric Research)
core
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source