Dual Lineages of Langerhans Cells Cooperate to Restore the Immune Barrier after Skin Injury
Advanced Science, EarlyView.After skin injury, the epidermal immune barrier is rebuilt by two sources of Langerhans cells. Resident Langerhans cells first move into the wound during re‐epithelialization, guided by CXCR2 signaling. Later, recruited monocytes become long‐lived Langerhans cells.
Axel D. Schmitter‐Sánchez +8 more
wiley +1 more source
CLRe: A Synergistic Dual‐Engine Framework for One‐Step Retrosynthesis Prediction
Advanced Science, EarlyView.CLRe uses a contrastive difficulty score to order pretrained seq2seq fine‐tuning for retrosynthesis. Reaction embeddings define the ranking score, and a cumulative easy‐to‐hard schedule expands from the easiest subset to the full training set while earlier examples remain active.
Tianhao Su +5 more
wiley +1 more source
Advanced Science, EarlyView.Corramycin, a myxobacterial natural product antibiotic, exhibits potent bactericidal activity against multidrug‐resistant Mycobacterium tuberculosis. The compound hijacks bacterial transporters such as BacA and OppABCD to enter the cell and inhibits DNA synthesis through a previously unrecognized mode of DNA gyrase poisoning, locking the enzyme in an ...
Franziska Fries +25 more
wiley +1 more source
Developing and Validating a Childhood Trauma-Informed Curriculum for Primary School Teachers in Limpopo Province, South Africa. [PDF]
Children (Basel)Munyadziwa M, Makhado L.
europepmc +1 more source
Nanoparticle‐Mediated Bubble Suppression During Droplet Solidification for Mechanical Reinforcement
Advanced Science, EarlyView.Nanoparticles mediate droplet solidification by raising nucleation temperature, refining dendrites, and slowing freezing‐front advance, thereby suppressing trapped air bubbles in droplet‐based 3D printing. This strategy reduces bubble volume fraction by ∼35% and increases compressive strength by up to 39%, offering a low‐cost route to stronger printed ...
Runmiao Gao +10 more
wiley +1 more source
Temporal dynamics of work engagement, job crafting, and job satisfaction in a Chinese educational context: a time-lagged study with primary school teachers. [PDF]
BMC PsycholPeng T, Gao J.
europepmc +1 more source
Advanced Science, EarlyView.FES‐derived MGE spheroids exhibit progenitor‐stage alterations in developmental trajectory and hypoxia‐responsive transcriptional programs, followed by functional disruption. Gestational hypoxia recapitulates impaired progenitor proliferation, shortened cell‐cycle progression, interneuron developmental abnormalities, and schizophrenia‐like behaviors in
Peiyan Ni +17 more
wiley +1 more source
Integrating multimedia training and microteaching in school-based oral health promotion: a mixed-methods study among primary school teachers and students in Gorontalo, Indonesia. [PDF]
Front Oral HealthPanna SS +5 more
europepmc +1 more source
İlköğretim OnlineThe aim of the current study was to explore the nature of primary school teachers' attitudes toward the integration of the English language in primary schools, based on a sample of 90 teachers from primary schools in Ghardaïa province. The study also aimed to examine whether there are statistically significant differences based on two variables: (1 ...
openaire +1 more source
From Circuits to Symphonies: A Systems‐Engineering Blueprint for Multimicrobial Synthetic Biology
Advanced Science, EarlyView.Engineering synthetic microbial consortia requires moving beyond intracellular genetic circuits toward coordinated multicellular design. A modular systems‐engineering framework is presented that integrates communication, temporal coordination, ecological structuring, and predictive modeling to guide application‐dependent consortium design ...
Miguel Fernández‐Niño +9 more
wiley +1 more source