Results 91 to 100 of about 1,974,671 (313)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Optimal learning spaces: design implications for primary schools [PDF]

, 2009
Review guide of the design evidence for primary ...
Barrett, PS, Zhang, Y
core  

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Antimicrobial resistance to colistin in neonates: epidemiological insights and public health implications in Nigeria – a mini review

Annals of Medicine
Introduction/Background Antimicrobial resistance (AMR) remains a critical global health issue, particularly in low- and middle-income countries like Nigeria.
Adewunmi Akingbola, Abiodun Christopher Adegbesan, Olaoluwa Olorunfemi, Kolade Adegoke, Kehinde Abereoje, Olajumoke Adewole, Victor Olamide Oluwasola, Somadila Igboanugo, Ademola Aiyenuro   +8 more
doaj   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Climate and Health Capacity Building for Health Professionals in Europe: A Pilot Course

International Journal of Public Health
ObjectivesThe European Climate and Health Responder Course aimed to enhance health professionals’ knowledge, confidence, and preparedness to address climate-related health challenges.MethodsThe course was delivered as a synchronous, online program ...
Tara T. Chen, Tara T. Chen, Ana-Catarina Pinho-Gomes, Ana-Catarina Pinho-Gomes, Nicola Hamacher, Marie Nabbe, Marie Nabbe, Kirsten Duggan, Doris Zjalic, Doris Zjalic, Danielly Magalhaes, Haley Campbell, Chiara Cadeddu, Chiara Cadeddu, Christiana A. Demetriou, Christiana A. Demetriou, Souzana Achilleos, Souzana Achilleos, Ianis Delpla, Ianis Delpla, Laurent Chambaud, Lore Leighton, Robert Otok, Kristie Hadley, Cecilia Sorensen   +24 more
doaj   +1 more source

Evaluation of voices foundation primer in primary schools [PDF]

, 2005
Music education has an important role in contributing towards society's needs in relation to the culture industries and continued development of active and constructive participation in musical activities.
Creech, Andrea, Hallam, Susan, Rogers, Lynne   +2 more
core  

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

How Primary School Students Perceive Primary School Teacher Exchange? [PDF]

Journal of Qualitative Research in Education, 2020
Mustafa Erol, Mustafa Başaran
openaire   +1 more source