Results 121 to 130 of about 1,996,761 (313)
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Teaching PSHE (and citizenship) in primary schools [PDF]
, 2006 This spotlight article looks at teaching PSHE and citizenship in primary ...
Adams, Paul
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Health SA Gesondheid: Journal of Interdisciplinary Health Sciences, 2012 The Department of Basic Education (DBE) has not given nutrition education the necessary emphasis that it needs, despite its importance in South African schools.
Wilna H. Oldewage-Theron +1 more
doaj
Harnessing Technology School survey 2008: report 1: analysis [PDF]
, 2008 This report summarises the main findings from the Harnessing Technology Schools Survey 2008, a national survey of ICT in primary, secondary and special schools. The research was carried out in 2007-08.
Coghlan, Misia +2 more
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Using ICT in the Primary School
, 2007 En este recurso se analiza el papel de la información y la comunicación tecnológica (TIC) en el contexto de la educación infantil y primaria. Tiene como objetivo proporcionar a los profesores la diferencia entre aprender habilidades de las TIC y la aplicación de las TIC.
openaire +2 more sources
Molecular Oncology, EarlyView.Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen +14 more
wiley +1 more source
Intended or unintended? Issues arising from the implementation of the UK Government’s 2003 Schools Workforce Remodelling Act [PDF]
, 2008 The United Kingdom (UK) Government's 2003 Workforce Remodelling Act (DfES, 2003) contained nine key points aimed at supporting teachers and schools to raise educational standards without adding additional workload responsibilities.
Blair, R, Capel, S
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source