Results 121 to 130 of about 396,045 (311)
, 2010 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.School days are organised on a whole day and or a shift basis in different countries.
Sherwood, Donna M
core
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Climate and Health Capacity Building for Health Professionals in Europe: A Pilot Course
International Journal of Public HealthObjectivesThe European Climate and Health Responder Course aimed to enhance health professionals’ knowledge, confidence, and preparedness to address climate-related health challenges.MethodsThe course was delivered as a synchronous, online program ...
Tara T. Chen +24 more
doaj +1 more source
Developing intercultural understanding in primary schools [PDF]
, 2015 This chapter explores cultural learning and intercultural understanding associated with foreign languages in primary schools. The chapter focuses primarily on the UK and more specifically on the English context. The issues explored, however, are relevant
Simpson, H., Driscoll, P.
core
Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma
Molecular Oncology, EarlyView.Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source
Utilization of ICT when doing science homeworks at England primary schools: Evidence from science teachers’handbook [PDF]
فصلنامه نوآوریهای آموزشی, 2008 The main purpose of this paper was to study how students use ICT when doing their homeworks according to the handbooks of England primary schools’ science teachers.
Bibi Eshrat Zamani, Seyyed Amin Azimi
doaj
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source