Results 71 to 80 of about 1,974,671 (313)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Supporting more able and talented pupils in primary schools [PDF]

, 2011
"This survey evaluates the effectiveness of strategies used by primary schools and local authorities to support and challenge more able and talented pupils.
Morgan, Sarah J., Newton, Lynda, Waldron, Janet   +2 more
core  

The National Singing Programme for primary schools in England: an initial baseline study [PDF]

, 2009
The ‘Sing Up’ National Singing Programme for Primary schools in England was launched in November 2007 under the UK Government’s ‘Music Manifesto’.
Hill, Joy, Himonides, Evangelos, Lani, Jennifer, Papageorgi, Ioulia, Preti, Costanza, Rinta, Tiija, Saunders, Jo, Stewart, Claire, Vraka, Maria, Welch, Graham   +9 more
core   +3 more sources

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

Effective Pre-school and Primary Education Project 3-11 (EPPE 3-11): the effectiveness of primary schools in England in Key Stage 2 for 2002, 2003 and 2004. [PDF]

, 2006
This report covers children\u27s progress during Key Stage 2 in all primary schools in England over a three year period (2002-2004). Value added multilevel models are used to investigate children\u27s progress in Key Stage 2 by controlling for prior ...
Melhuish, Edward, Romaniuk, Helena, Sammons, Pam, Siraj-Blatchford, Iram, Sylva, Kathy, Taggart, Brenda   +5 more
core   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Analysis of primary teacher stress' sources [PDF]

Psihološka Obzorja, 2011
Teachers are subject to many different work stressors. This study focused on differences in intensity and frequency of potential stressors facing primary schoolteachers and set the goal to identify the most important sources of teacher stress in primary ...
Katja Depolli Steiner
doaj  

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

LET’S TALK FOOD: ELEMENTARY SCHOOL STUDENTS’ PERCEPTIONS OF SCHOOL AND HOME FOOD ENVIRONMENT AND THE IMPACT OF THE HARVEST OF THE MONTH PROGRAM ON THEIR DIETARY ATTITUDES AND BEHAVIORS

International Journal of Child, Youth & Family Studies, 2018
This study aimed to further knowledge about elementary school students’ views on food environment, and the effects of the Harvest of the Month (HOTM) program on their dietary attitudes and behaviors.
Amanda Margolin, Keiko Goto, Cindy Wolff, Stephanie Bianco   +3 more
doaj   +1 more source