Results 1 to 10 of about 62,620 (348)

Multitrait genome-wide analyses identify new susceptibility loci and candidate drugs to primary sclerosing cholangitis

Nature Communications, 2023
The genetic basis of primary sclerosing cholangitis has only been partially uncovered. Here, the authors perform a multitrait genome-wide association study to provide insight into the genetic etiology of primary sclerosing cholangitis risk and possible ...
Younghun Han, Jinyoung Byun, Catherine Zhu, Ryan Sun, Julia Y. Roh, Heather J. Cordell, Hyun-Sung Lee, Vikram R. Shaw, Sung Wook Kang, Javad Razjouyan, Matthew A. Cooley, Manal M. Hassan, Katherine A. Siminovitch, Trine Folseraas, David Ellinghaus, Annika Bergquist, Simon M. Rushbrook, Andre Franke, Tom H. Karlsen, Konstantinos N. Lazaridis, The International PSC Study Group, Katherine A. McGlynn, Lewis R. Roberts, Christopher I. Amos   +23 more
doaj   +2 more sources

Primary sclerosing cholangitis. [PDF]

Translational Gastroenterology and Hepatology, 2021
Primary sclerosing cholangitis (PSC) is a rare chronic cholestatic liver disease characterized by inflammatory destruction of the intrahepatic and/or extrahepatic bile ducts, leading to bile stasis, fibrosis, and ultimately to cirrhosis, and often ...
A. Rabiee, M. Silveira
semanticscholar   +3 more sources

Primary sclerosing cholangitis [PDF]

Canadian Journal of Gastroenterology, 2008
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts, resulting in end-stage liver disease and reduced life expectancy.
Marina G Silveira, Keith D Lindor
doaj   +5 more sources

Primary sclerosing cholangitis [PDF]

Orphanet Journal of Rare Diseases, 2006
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology characterised by inflammation and fibrosis of the biliary tree. The mean age at diagnosis is 40 years and men are affected twice as often as women.
Chapman Roger, Worthington Joy
doaj   +7 more sources

Secondary sclerosing cholangitis: mimics of primary sclerosing cholangitis

Abdominal Radiology, 2022
Sclerosing cholangitis is a chronic cholestatic disease characterized by stricturing, beading, and obliterative fibrosis of the bile ducts. Sclerosing cholangitis is considered primary (PSC) if no underlying etiology is identified or secondary (SSC) if ...
D. Ludwig, Mark A. Anderson, M. Itani, Kedar G. Sharbidre, N. Lalwani, R. Paspulati   +5 more
semanticscholar   +3 more sources

Primary Sclerosing Cholangitis

Canadian Journal of Gastroenterology, 2000
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by fibrosing inflammation and obliteration of intra- and/or extrahepatic bile ducts.
A Stiehl, C Benz, P Sauer
doaj   +6 more sources

British Society of Gastroenterology and UK-PSC guidelines for the diagnosis and management of primary sclerosing cholangitis

Gut, 2019
These guidelines on the management of primary sclerosing cholangitis (PSC) were commissioned by the British Society of Gastroenterology liver section. The guideline writing committee included medical representatives from hepatology and gastroenterology ...
Michael Huw Chapman, Gideon Hirschfield, Stephen P Pereira   +2 more
exaly   +2 more sources

The Nonsteroidal Farnesoid X Receptor Agonist Cilofexor (GS‐9674) Improves Markers of Cholestasis and Liver Injury in Patients With Primary Sclerosing Cholangitis

Hepatology, 2019
Primary sclerosing cholangitis (PSC) represents a major unmet medical need. In a phase II double‐blind, placebo‐controlled study, we tested the safety and efficacy of cilofexor (formerly GS‐9674), a nonsteroidal farnesoid X receptor agonist in patients ...
Michael Trauner, Kosh Agarwal, Andrew J Muir   +2 more
exaly   +2 more sources

IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis

Gut and Liver, 2019
Sclerosing cholangitis (SC) is defined as a condition with progressive stenosis and destruction of the bile ducts due to diffuse inflammation and fibrosis and currently includes three categories: primary sclerosing cholangitis (PSC), secondary ...
Atsushi Tanaka
doaj   +4 more sources

Primary Sclerosing Cholangitis Associated with Severe Ulcerative Colitis in a Young Woman: Case Report

Journal of Ardabil University of Medical Sciences, 2019
Background: Primary sclerosing cholangitis is a rare and progressive cholestatic disease characterized by narrowing of the biliary tract. Despite high levels of ulcerative colitis, early diagnosis of primary sclerosing cholangitis before the diagnosis of
Somaieh Matin, yousef Imani Marani, Hossein Salehzadeh   +2 more
doaj   +1 more source