Results 11 to 20 of about 4,318,091 (252)
Primary sclerosing cholangitis [PDF]
Canadian Journal of Gastroenterology, 2008 Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by inflammation and fibrosis of the bile ducts, resulting in end-stage liver disease and reduced life expectancy.
Marina G Silveira, Keith D Lindor
doaj +5 more sources
IgG4-Related Sclerosing Cholangitis and Primary Sclerosing Cholangitis
Gut and Liver, 2019 Sclerosing cholangitis (SC) is defined as a condition with progressive stenosis and destruction of the bile ducts due to diffuse inflammation and fibrosis and currently includes three categories: primary sclerosing cholangitis (PSC), secondary ...
Atsushi Tanaka
doaj +2 more sources
Primary sclerosing cholangitis
Best Practice & Research Clinical Gastroenterology, 2010 Primary sclerosing cholangitis (PSC) is a chronic bile duct disease leading to fibrotic biliary strictures and liver cirrhosis. The patient population is heterogeneous with regard to disease progression and the presence of co-morbidities, complicating the practical handling of patients as well as studies of pathogenetic mechanisms. The aetiology of PSC
Tom H, Karlsen +2 more
core +7 more sources
Primary sclerosing cholangitis
Nature Reviews Disease PrimersPrimary sclerosing cholangitis (PSC) is a chronic biliary inflammation associated with periductular fibrosis of the intrahepatic and extrahepatic bile ducts leading to strictures, bacterial cholangitis, decompensated liver disease and need for liver transplantation.
Michael P. Manns +8 more
europepmc +5 more sources
Primary sclerosing cholangitis
The Lancet, 2018 Primary sclerosing cholangitis is a rare, chronic cholestatic liver disease characterised by intrahepatic or extrahepatic stricturing, or both, with bile duct fibrosis. Inflammation and fibrosis of bile ducts and the liver are followed by impaired bile formation or flow and progressive liver dysfunction.
Dyson JK +4 more
core +9 more sources
Primary sclerosing cholangitis [PDF]
Orphanet Journal of Rare Diseases, 2006 Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease of unknown aetiology characterised by inflammation and fibrosis of the biliary tree. The mean age at diagnosis is 40 years and men are affected twice as often as women.
Chapman Roger, Worthington Joy
doaj +7 more sources
Primary Sclerosing Cholangitis
Clinics in Liver Disease, 2013 Primary sclerosing cholangitis (PSC) is a chronic, progressive, cholestatic liver disease characterized by multifocal strictures of intra and extrahepatic bile ducts. PSC occurs more commonly in men and is often associated with inflammatory bowel disease. At present, there is no effective medical therapy for PSC. Current management of patients with PSC
Gideon M, Hirschfield +3 more
core +5 more sources
Primary Sclerosing Cholangitis
Canadian Journal of Gastroenterology, 2000 Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterized by fibrosing inflammation and obliteration of intra- and/or extrahepatic bile ducts.
A Stiehl, C Benz, P Sauer
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Fine-mapping and molecular characterisation of primary sclerosing cholangitis genetic risk loci [PDF]
Nature CommunicationsGenome-wide association studies of primary sclerosing cholangitis have identified 23 susceptibility loci. The majority of these loci reside in non-coding regions of the genome and are thought to exert their effect by perturbing the regulation of nearby ...
Elizabeth C. Goode +10 more
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Medičnì PerspektiviPrimary sclerosing cholangitis and autoimmune sclerosing cholangitis in children are rare chronic liver diseases characterized by progressive bile duct damage, fibrogenesis, and a risk of developing biliary cirrhosis. Autoimmune sclerosing cholangitis is
M.B. Dyba +3 more
doaj +2 more sources