Results 31 to 40 of about 121,676 (256)
REMEDI: REinforcement learning-driven adaptive MEtabolism modeling of primary sclerosing cholangitis DIsease progression [PDF]
arXiv, 2023 Primary sclerosing cholangitis (PSC) is a rare disease wherein altered bile acid metabolism contributes to sustained liver injury. This paper introduces REMEDI, a framework that captures bile acid dynamics and the body's adaptive response during PSC progression that can assist in exploring treatments.
arxiv
Latent class mixed modelling for phenotypic stratification of primary biliary cholangitis patients on first line treatment [PDF]
arXiv, 2022 In patients with primary biliary cholangitis (PBC), the serum liver biochemistry measured during treatment with ursodeoxycholic acid (the UDCA response) accurately predicts long-term outcome. In this study we sought to use liver biochemistry, and in particular alkaline phosphatase (ALP), as a surrogate marker of disease activity, for phenotypic ...
arxiv
Journal of Medical Case Reports, 2010 Introduction Although myasthenia gravis is frequently associated with other disorders, it has not been reported together with primary sclerosing cholangitis, complicating the administration of liver-toxic immunosuppressive therapy. Case presentation A 73-
Höflich Sonja, Finsterer Josef
doaj +1 more source
Journal of Medical Case Reports, 2021 Background Autoimmune hepatitis–primary sclerosing cholangitis overlap syndrome is a form of autoimmune hepatitis with cholestatic features and is characterized by negative anti-mitochondrial antibody and cholangiographic changes on magnetic resonance ...
Behzad Hatami +2 more
doaj +1 more source
Pathogens, 2023 Primary sclerosing cholangitis is an important reason for liver transplantation. Hepatic alveolar echinococcosis (AE) is caused by Echinococcus multilocularis and presents characteristic calcified conglomerates detected by ultrasound or computed ...
Florian Fronhoffs +15 more
doaj +1 more source
Maximum likelihood estimation of hidden Markov models for continuous longitudinal data with missing responses and dropout [PDF]
arXiv, 2021 We propose an inferential approach for maximum likelihood estimation of the hidden Markov models for continuous responses. We extend to the case of longitudinal observations the finite mixture model of multivariate Gaussian distributions with Missing At Random (MAR) outcomes, also accounting for possible dropout.
arxiv
Primary sclerosing cholangitis
Autoimmunity Reviews, 2003 Primary sclerosing cholangitis (PSC) is a fibrosing disease of the intra- and extra-hepatic bile ducts, and is closely associated with inflammatory bowel disease. It is immune mediated, rather than being a classical autoimmune disease. A range of immune abnormalities have been demonstrated in PSC, in particular the findings of a range of autoantibodies,
Cullen, S, Chapman, R
openaire +3 more sources
Deep Generative Survival Analysis: Nonparametric Estimation of Conditional Survival Function [PDF]
arXiv, 2022 We propose a deep generative approach to nonparametric estimation of conditional survival and hazard functions with right-censored data. The key idea of the proposed method is to first learn a conditional generator for the joint conditional distribution of the observed time and censoring indicator given the covariates, and then construct the Kaplan ...
arxiv
Characteristic features of ulcerative colitis with concomitant primary sclerosing cholangitis
Gastroenterology Review, 2021 Ulcerative colitis is a chronic inflammatory bowel disease of the colon. The most frequent symptoms include bloody diarrhoea with rectal urgency and tenesmus.
Artur W. Uździcki +1 more
doaj +1 more source