Results 71 to 80 of about 27,193 (247)

Medical Management of Chronic Cholestatic Liver Diseases

Canadian Journal of Gastroenterology, 2000
The purpose of the present review is to discuss the diagnosis and management of cholestatic liver diseases. Differential diagnoses to consider are described, including causes of extrahepatic biliary obstruction such as gallstones, strictures ...
Andrea A Gossard, Keith D Lindor
doaj   +1 more source

An update on primary sclerosing cholangitis.

, 2008
PURPOSE OF REVIEW: Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by strictures of the biliary tree complicated by cirrhosis and cholangiocarcinoma.
Chapman, RW, Maggs, JR
core   +1 more source

Serum autoantibodies, ulcerative colitis and primary sclerosing cholangitis.

, 1986
The aetiology of primary sclerosing cholangitis is unknown, but it is closely associated with ulcerative colitis. Serum anticolon antibodies, crossreacting with portal tracts, have been reported in patients with ulcerative colitis but no studies have ...
Selby, WS, Sherlock, S, W S Selby, S Sherlock, Jewell, DP, Shepherd, HA, R W Chapman, D P Jewell, M Cottone, H A Shepherd, Cottone, M, Chapman, RW   +11 more
core   +1 more source

Circulating markers of gut barrier function associated with disease severity in primary sclerosing cholangitis [PDF]

, 2018
Background & Aims: One important hypothesis in primary sclerosing cholangitis pathophysiology suggests that bacterial products from an inflamed leaky gut lead to biliary inflammation.
Dhillon, Amandeep Kaur, Liaskou, Evaggelia, Trøseid, Marius, Moum, Bjørn, Hov, Johannes Espolin Roksund, Karlsen, Tom Hemming, Vesterhus, Mette, Åkra, Sissel, Kummen, Martin, Seljeflot, Ingebjørg   +9 more
core   +1 more source

Vancomycin Therapy for Induction and Maintenance of Remission in a Patient with Refractory Ulcerative Colitis and Primary Sclerosing Cholangitis: A Case Report and Literature Review

Case Reports in Gastroenterology
Introduction: Ulcerative colitis is a chronic inflammatory bowel disease that affects the colon. About 5% of ulcerative colitis patients also present with primary sclerosing cholangitis, a chronic inflammatory disease marked by cholestasis and
Naama Lang, Yana Davidov, Tomer Hoffman, Sivan Harnik, Abraham Rami Eliakim, Shomron Ben-Horin, Bella Ungar   +6 more
doaj   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

AUTOIMMUNE LIVER DAMAGE IN PATIENT WITH LYELL`S SYNDROME

Медицина в Кузбассе, 2019
Autoimmune hepatitis (AIH), primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) are independent liver diseases. But in some cases, patients have syndromes of several liver disease.
Елена Анатольевна Талицкая, Алексей Анатольевич Близнюк, Ольга Константиновна Саблина, Светлана Владимировна Калитина   +3 more
doaj  

Current Cell/Organoid and Animal Models for Primary Sclerosing Cholangitis

Portal Hypertension &Cirrhosis, EarlyView.
Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease with limited therapeutic options and a marked risk of progression to biliary fibrosis, cirrhosis, and malignancy. Progress in PSC research has been hindered by the lack of models that faithfully recapitulate the complex biliary microenvironment and disease heterogeneity ...
Qigu Yao, Sheng Cheng, Qiaoling Pan, Jiong Yu, Hongcui Cao   +4 more
wiley   +1 more source

The Changing Face of the Diagnosis of Chronic and Malignant Liver Diseases: Potential New Biomarkers

Annals of Hepatology, 2018
The early diagnosis of primary sclerosing cholangitis, hepatocellular carcinoma, and cholangiocarcinoma is often challenging. In a recent study in 134 patients (Arbelaiz, Hepatology 2017; 66: 1125-43), it was reported that specific proteins found in ...
Vania Cruz-Ramón, Paulina Chinchilla-López, Oscar Ramírez-Pérez, Xingshun Qi, Nahum Méndez-Sánchez   +4 more
doaj   +1 more source

The management of primary sclerosing cholangitis.

, 1998
Primary sclerosing cholangitis is a chronic cholestatic liver disease characterized by a progressive, obliterating fibrosis of the intrahepatic and extrahepatic bile ducts.
Mitchell, SA, Chapman, RW
core   +1 more source