Results 1 to 10 of about 8,351,434 (307)

Clinical Outcomes of Metastatic Colorectal Cancer Following Surgical Resection of the Primary tumor at Hiwa Cancer Hospital, Sulaimani, Iraq [PDF]

Disease and Diagnosis, 2021
Background: Colorectal cancer (CRC) is one of the main causes of cancer-related mortality. The surgical resection of primary CRC tumors is a critical line of treatment. The present study investigated the clinical outcomes of the surgical resection of the
Kadhim Faruq Namiq, Kosar Mohammad Ali, Mohammed Ibrahim Mohialdeen Gubari   +2 more
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Primary tumor associated macrophages activate programs of invasion and dormancy in disseminating tumor cells

Nature Communications, 2022
Metastases are initiated by disseminated tumor cells (DTCs) that colonize distant organs. Growing evidence suggests that the microenvironment of the primary tumor primes DTCs for dormant or proliferative fates.
L. Borriello, A. Coste, Brian Traub, V. Sharma, G. Karagiannis, Yu Lin, Yarong Wang, X. Ye, Camille L. Duran, Xiaoming Chen, Madeline Friedman, M. Sosa, Dan Sun, E. Dalla, Deepak K. Singh, M. Oktay, J. Aguirre-Ghiso, J. Condeelis, D. Entenberg   +18 more
semanticscholar   +1 more source

Primary Tumor Resection Plus Chemotherapy Versus Chemotherapy Alone for Colorectal Cancer Patients With Asymptomatic, Synchronous Unresectable Metastases (JCOG1007; iPACS): A Randomized Clinical Trial

Journal of Clinical Oncology, 2021
PURPOSE It remains controversial whether primary tumor resection (PTR) before chemotherapy improves survival in patients with colorectal cancer (CRC) with asymptomatic primary tumor and synchronous unresectable metastases.
Y. Kanemitsu, K. Shitara, J. Mizusawa, T. Hamaguchi, D. Shida, K. Komori, S. Ikeda, H. Ojima, H. Ike, A. Shiomi, J. Watanabe, Y. Takii, T. Yamaguchi, K. Katsumata, Masaaki Ito, J. Okuda, R. Hyakudomi, Y. Shimada, H. Katayama, H. Fukuda   +19 more
semanticscholar   +1 more source

Assessing Various Control Samples for Microarray Gene Expression Profiling of Laryngeal Squamous Cell Carcinoma

Biomolecules, 2021
Selection of optimal control samples is crucial in expression profiling tumor samples. To address this issue, we performed microarray expression profiling of control samples routinely used in head and neck squamous cell carcinoma studies: human bronchial
Adam Ustaszewski, Magdalena Kostrzewska-Poczekaj, Joanna Janiszewska, Malgorzata Jarmuz-Szymczak, Malgorzata Wierzbicka, Joanna Marszal, Reidar Grénman, Maciej Giefing   +7 more
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Oral administration of bovine milk-derived extracellular vesicles induces senescence in the primary tumor but accelerates cancer metastasis

Nature Communications, 2021
The concept that extracellular vesicles (EVs) from the diet can be absorbed by the intestinal tract of the consuming organism, be bioavailable in various organs, and in-turn exert phenotypic changes is highly debatable. Here, we isolate EVs from both raw
Monisha Samuel, P. Fonseka, Rahul Sanwlani, Lahiru Gangoda, S. Chee, Shivakumar Keerthikumar, A. Spurling, Sai V. Chitti, D. Zanker, C. Ang, I. Atukorala, Taeyoung Kang, S. Shahi, Akbar L. Marzan, Christina Nedeva, C. Vennin, M. Lucas, Lesley Cheng, D. Herrmann, Mohashin Pathan, David Chisanga, S. Warren, Kening Zhao, Nidhin Abraham, Sushma Anand, Stephanie Boukouris, Christopher G. Adda, Lanzhou Jiang, Tanmay M. Shekhar, N. Baschuk, C. Hawkins, Amelia J. Johnston, J. Orian, N. Hoogenraad, I. Poon, A. Hill, M. Jois, P. Timpson, B. Parker, S. Mathivanan   +39 more
semanticscholar   +1 more source

Pre-Operative Prediction of Mediastinal Node Metastasis Using Radiomics Model Based on 18F-FDG PET/CT of the Primary Tumor in Non-Small Cell Lung Cancer Patients

Frontiers in Medicine, 2021
Purpose: We investigated whether a fluorine-18-fluorodeoxy glucose positron emission tomography/computed tomography (18F-FDG PET/CT)-based radiomics model (RM) could predict the pathological mediastinal lymph node staging (pN staging) in patients with ...
Kai Zheng, Kai Zheng, Kai Zheng, Xinrong Wang, Chengzhi Jiang, Yongxiang Tang, Zhihui Fang, Jiale Hou, Zehua Zhu, Shuo Hu, Shuo Hu, Shuo Hu   +11 more
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Colon Tissues Classification and Localization in Whole Slide Images Using Deep Learning

Diagnostics, 2021
Colorectal cancer is one of the leading causes of cancer-related death worldwide. The early diagnosis of colon cancer not only reduces mortality but also reduces the burden related to the treatment strategies such as chemotherapy and/or radiotherapy ...
Pushpanjali Gupta, Yenlin Huang, Prasan Kumar Sahoo, Jeng-Fu You, Sum-Fu Chiang, Djeane Debora Onthoni, Yih-Jong Chern, Kuo-Yu Chao, Jy-Ming Chiang, Chien-Yuh Yeh, Wen-Sy Tsai   +10 more
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Immunoexpression of p53 mutant-type in Iranian patients with primary and recurrence oral squamous cell carcinoma

European Journal of Translational Myology, 2022
Mutations in tumor suppressor p53 protein can occur at different phases of malignant transformation and affect the patient's prognosis. This study aimed to evaluate the expression of mutant p53 protein in Iranian patients with the primary and recurrence
Hossein Daneste, Azita Sadeghzadeh, Maral Mokhtari, Hossein Mohammadkhani, Fatemeh Lavaee, Javad Moayedi   +5 more
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Asymptomatic Primary Tumor Resection in Metastatic Colorectal Cancer: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
BackgroundIn patients with metastatic colorectal cancer (mCRC) with an asymptomatic primary tumor, there is no consensus on the indication for resection of the primary tumor.MethodsThe PubMed, Embase and the Cochrane Library databases were searched from ...
Yefei Shu, Ling Xu, Wei Yang, Xiaofeng Xu, Song Zheng, Song Zheng   +5 more
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Tumor microenvironment differences between primary tumor and brain metastases

Journal of Translational Medicine, 2020
The present review aimed to discuss contemporary scientific literature involving differences between the tumor microenvironment (TME) in melanoma, lung cancer, and breast cancer in their primary site and TME in brain metastases (BM).
B. Cacho-Díaz, Donovan R. García-Botello, T. Wegman-Ostrosky, G. Reyes-Soto, E. Ortiz-Sánchez, L. Herrera-Montalvo   +5 more
semanticscholar   +1 more source