Results 91 to 100 of about 8,351,434 (307)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Risk of invasive breast cancer in relatives of patients with breast carcinoma in situ: a prospective cohort study

BMC Medicine, 2020
Background Wide implementation of mammography screening has resulted in increased numbers of women diagnosed with breast carcinoma in situ. We aimed to determine the risk of invasive breast cancer in relatives of patients with breast carcinoma in situ in
Trasias Mukama, Mahdi Fallah, Hermann Brenner, Xing Xu, Kristina Sundquist, Jan Sundquist, Elham Kharazmi   +6 more
doaj   +1 more source

Anti-Tumor Effects of TRAIL-Expressing Mesenchymal Stromal Cells in a Mouse Xenograft Model of Human Mesothelioma [PDF]

, 2015
Malignant mesothelioma (MM) remains a highly deadly malignancy with poor treatment option. The MM cells further promote a highly inflammatory microenvironment which contributes to tumor initiation, development, severity, and propagation. We reasoned that
Janes, SM, Sage, E
core  

A Pilot Study Comparing HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas by Whole Exome Sequencing. [PDF]

, 2012
Background. Next-generation sequencing of cancers has identified important therapeutic targets and biomarkers. The goal of this pilot study was to compare the genetic changes in a human papillomavirus- (HPV-)positive and an HPV-negative head and neck ...
Barrett, John W, Basmaji, John, Boutros, Paul, Chan-Seng-Yue, Michelle, Dhaliwal, Sandeep, Dowthwaite, Samuel, Franklin, Jason H, Fung, Kevin, Koropatnick, James, Kwan, Keith, Lambin, Philippe, Mymryk, Joe S, Nichols, Anthony C, Palma, David A, Starmans, Maud HW, Szeto, Christopher CT, Todorovic, Biljana, Wehrli, Bret, Xu, Wei, Yoo, John   +19 more
core   +3 more sources

Extradural Primary Malignant Spinal Tumors in a Population Younger than 25 Years: An Ambispective International Multicenter Study on Onco-Surgical Outcomes [PDF]

, 2023
Alexander C. Disch, Stefano Boriani, Alessandro Luzzati, Laurence D. Rhines, Charles G. Fisher, Áron Lazáry, Ziya L. Gokaslan, Dean Chou, Michelle J. Clarke, Michael G. Fehlings, Klaus‐Dieter Schaser, Nicole M. Germscheid, Jeremy Reynolds, The AO Spine Knowledge Forum Tumor   +13 more
openalex   +1 more source

Concordance of folate receptor-α expression between biopsy, primary tumor and metastasis in breast cancer and lung cancer patients

OncoTarget, 2016
Folate receptor alpha (FRα) is known to be upregulated in a variety of cancers, including non-small cell lung cancer (NSCLC) and breast cancer. To ensure reliable implementation of diagnostic- and therapeutic agents, concordance of FRα expression between
L. Boogerd, M. C. Boonstra, A. Beck, A. Charehbili, Charlotte E. S. Hoogstins, H. A. Prevoo, S. Singhal, P. Low, C. J. van de Velde, A. Vahrmeijer   +9 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

PET/CT and MR Improve Interobserver Agreement in Primary Tumor Determination for Radiotherapy in Esophageal Squamous Cell Cancer

Diagnostics
Background/Objectives: The aim of the study was to evaluate interobserver variability in the determination of the primary tumor for radiotherapy treatment planning in esophageal squamous cell carcinoma (ESCC).
Ajra Secerov-Ermenc, Primoz Peterlin, Vaneja Velenik, Ana Jeromen-Peressutti, Jasna But-Hadzic, Franc Anderluh, Barbara Segedin   +6 more
doaj   +1 more source

Drug response in organoids generated from frozen primary tumor tissues

Scientific Reports, 2016
Primary tumor organoids grown in three-dimensional culture provide an excellent platform for studying tumor progression, invasion and drug response. However, organoid generation protocols require fresh tumor tissue, which limits organoid research and ...
Alex J. Walsh, R. Cook, M. Sanders, C. Arteaga, M. Skala   +4 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source