Results 151 to 160 of about 8,351,434 (307)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Unexpected Primary Pleural Melanoma Simulating a Chest Wall Tumor

, 2021
María José Moyano-Rodríguez, Paula Bravo-Carmona, Ana María Gómez-Gago   +2 more
openalex   +2 more sources

Prognostic and Predictive Relevance of Primary Tumor Location in Patients With RAS Wild-Type Metastatic Colorectal Cancer: Retrospective Analyses of the CRYSTAL and FIRE-3 Trials

JAMA Oncology, 2017
S. Tejpar, S. Stintzing, F. Ciardiello, J. Tabernero, E. Van Cutsem, F. Beier, R. Esser, H. Lenz, V. Heinemann   +8 more
semanticscholar   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Supplementary Data from Exposure–Toxicity Association of Cyclophosphamide and Its Metabolites in Infants and Young Children with Primary Brain Tumors: Implications for Dosing [PDF]

, 2023
Olivia Campagne, Bo Zhong, Sreenath Nair, Tong Lin, Jie Huang, Arzu Onar‐Thomas, Giles Robinson, Amar Gajjar, Clinton F. Stewart   +8 more
openalex   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source

Correction to: Analysis of primary tumor metabolic volume during chemoradiotherapy in locally advanced non-small cell lung cancer [PDF]

, 2018
Olarn Roengvoraphoj, Cherylina Wijaya, Chukwuka Eze, Minglun Li, M. Dantes, Julian Taugner, Amanda Tufman, Rudolf M. Huber, Claus Belka, Farkhad Manapov   +9 more
openalex   +1 more source

Supplementary Table 4 from Surveillance of the Tumor Mutanome by T Cells during Progression from Primary to Recurrent Ovarian Cancer

, 2023
Darin A. Wick, John R. Webb, Julie S. Nielsen, Spencer D. Martin, David R. Kroeger, Katy Milne, Mauro Castellarin, Kwame Twumasi‐Boateng, Peter H. Watson, Robert A. Holt, Brad H. Nelson   +10 more
openalex   +1 more source

Supplementary Figure 2 from Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma [PDF]

, 2023
Zhiqiang Qin, Lu Dai, Jimena Trillo-Tinoco, Can E. Senkal, Wenxue Wang, Tom Reske, Karlie Bonstaff, Luís J. del Valle, Paulo C. Rodrı́guez, Erik K. Flemington, Christina Voelkel‐Johnson, Charles D. Smith, Besim Öğretmen, E. C. M. Parsons   +13 more
openalex   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source