Myeloid suppressor cell depletion augments antitumor activity in lung cancer. [PDF]
, 2012 BackgroundMyeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine ...
Dubinett, Steven +10 more
core +10 more sources
European Journal of Translational Myology, 2022 Mutations in tumor suppressor p53 protein can occur at different phases of malignant transformation and affect the patient's prognosis. This study aimed to evaluate the expression of mutant p53 protein in Iranian patients with the primary and recurrence
Hossein Daneste +5 more
doaj +1 more source
Frontiers in Oncology, 2022 BackgroundIn patients with metastatic colorectal cancer (mCRC) with an asymptomatic primary tumor, there is no consensus on the indication for resection of the primary tumor.MethodsThe PubMed, Embase and the Cochrane Library databases were searched from ...
Yefei Shu +5 more
doaj +1 more source
Locoregional treatment of de novo stage IV breast cancer in the era of modern oncology
Frontiers in Oncology, 2023 Approximately 6% of metastatic breast cancers arise de novo. While systemic therapy (ST) remains the treatment backbone as for patients with metachronous metastases, locoregional treatment (LRT) of the primary tumor remains a controversial method.
Filippo Merloni +13 more
doaj +1 more source
Lymph node metastasis of squamous cell carcinoma from an unknown primary in the upper and middle neck: impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography [PDF]
, 2011 Purpose: The purpose of this study was to assess the potential of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging for detection of the primary tumor and its impact on treatment planning in patients presenting
Bonte, Katrien +3 more
core +1 more source
Does asymptomatic primary tumor need to be removed in unresectable metastatic colon cancer?
Тазовая хирургия и онкология, 2015 Every third colorectal cancer patient has inoperable metastatic disease upon diagnosis. And quite often the primary tumor is asymptomatic. The question stands for surgeon and medical oncologist, whether to proceed with upfront surgery or systemic ...
M. Yu. Fedyanin +2 more
doaj +1 more source
The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance [PDF]
, 2018 Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases.
Chiarella, Paula +3 more
core +1 more source
Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. [PDF]
, 2019 Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies.
Ames, Erik +8 more
core +1 more source
Mechanisms of cyst formation in metastatic lymph nodes of head and neck squamous cell carcinoma
Diagnostic Pathology, 2012 Cystic change in metastatic lymph nodes occurs in certain types of tumors and mostly in squamous cell carcinoma of the head and neck. In the majority of cases, psuedocystic change is the mechanism of cyst formation.
Mokhtari Sepideh
doaj +1 more source
Regulation of Immunity in Clear Cell Renal Carcinoma: Role of PD-1, PD-L1, and PD-L2
Current Issues in Molecular Biology, 2021 Regulation of immunity is a unique oncogenic mechanism that differs in different cancers. VHL deficient clear cell renal cell carcinomas (ccRCC) trigger the immune response resulting in cancer progression. This study aimed to investigate PD-1, PD-L1, and
Liudmila Spirina +5 more
doaj +1 more source