Results 11 to 20 of about 8,351,434 (307)

Myeloid suppressor cell depletion augments antitumor activity in lung cancer. [PDF]

, 2012
BackgroundMyeloid derived suppressor cells (MDSC) are important regulators of immune responses. We evaluated the mechanistic role of MDSC depletion on antigen presenting cell (APC), NK, T cell activities and therapeutic vaccination responses in murine ...
Dubinett, Steven, Elashoff, David, Harris-White, Marni, Huang, Min, Johnson, Ming F, Kar, Upendra K, Lee, Jay M, Sharma, Sherven, Srivastava, Minu K, Strieter, Robert, Zhu, Li   +10 more
core   +10 more sources

Mapping distribution of brain metastases: does the primary tumor matter?

Journal of Neuro-Oncology, 2020
Purpose Prior reports on the location and sizes of brain metastases almost entirely focus on patients with primary breast and pulmonary cancer. This is the first study comparing multiple other types of cancer that metastasize to the brain.
T. Schroeder, Paul Bittrich, Jan Felix Kuhne, C. Noebel, H. Leischner, J. Fiehler, Julian Schroeder, Gerhard Schoen, S. Gellissen   +8 more
semanticscholar   +1 more source

Locoregional treatment of de novo stage IV breast cancer in the era of modern oncology

Frontiers in Oncology, 2023
Approximately 6% of metastatic breast cancers arise de novo. While systemic therapy (ST) remains the treatment backbone as for patients with metachronous metastases, locoregional treatment (LRT) of the primary tumor remains a controversial method.
Filippo Merloni, Michela Palleschi, Caterina Gianni, Chiara Casadei, Annalisa Curcio, Antonino Romeo, Maddalena Rocchi, Simona Cima, Marianna Sirico, Samanta Sarti, Lorenzo Cecconetto, Marita Mariotti, Giandomenico Di Menna, Ugo De Giorgi   +13 more
doaj   +1 more source

Expert consensus on diagnosis and treatment of hematologic malignancies with solid tumors (2025 version) [PDF]

Zhongguo aizheng zazhi
Hematologic malignancies with solid tumors (HM-ST), a special subtype of multiple primary malignancies (MPMs), are increasingly encountered in clinical practice, posing significant diagnostic and therapeutic challenges.
Multiple Primary and Unknown Primary Tumors Special Committee of China Anti-Cancer Association , Shanghai Anti Cancer Association Multiple Primary and Unknown Primary Tumor Special Committee , Lymphocytic Disease Group, Hematology Branch, Chinese Medical Association , Rare Disease Group, Hematology Branch, Chinese Medical Association
doaj   +1 more source

Lymph node metastasis of squamous cell carcinoma from an unknown primary in the upper and middle neck: impact of 18F-fluorodeoxyglucose positron emission tomography/computed tomography [PDF]

, 2011
Purpose: The purpose of this study was to assess the potential of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) imaging for detection of the primary tumor and its impact on treatment planning in patients presenting
Bonte, Katrien, Deron, Philippe, Van De Wiele, Christophe, Vermeersch, Hubert   +3 more
core   +1 more source

Regulation of Immunity in Clear Cell Renal Carcinoma: Role of PD-1, PD-L1, and PD-L2

Current Issues in Molecular Biology, 2021
Regulation of immunity is a unique oncogenic mechanism that differs in different cancers. VHL deficient clear cell renal cell carcinomas (ccRCC) trigger the immune response resulting in cancer progression. This study aimed to investigate PD-1, PD-L1, and
Liudmila Spirina, Zahar Yurmazov, Evgeny Usynin, Irina Kondakova, Ekaterine Ladutko, Evgeny Choynzonov   +5 more
doaj   +1 more source

Case report: Using DNA short tandem repeats to confirm nongestational origin of pulmonary choriocarcinoma

Frontiers in Oncology, 2022
Gestational trophoblastic neoplasias (GTN) are malignant neoplasms that occur in pregnant or recently pregnant women. Choriocarcinoma (CCA) is a highly aggressive and rare GTN, and cases outside the female genital tract are commonly seen as secondary ...
Filipa Ferreira da Silva, Rita Barata, Inês Rolim, Catarina Carvalheiro, Nuno Gil, Marcos Pantarotto   +5 more
doaj   +1 more source

The acceleration of metastases after tumor removal and the paradoxical phenomenon of concomitant tumor resistance [PDF]

, 2018
Although surgical extirpation of tumors is usually clinically recommended, tumor removal may entail an undesired side effect: the risk of accelerating the growth of metastases.
Chiarella, Paula, Meiss, Roberto P., Montagna, Daniela Romina, Ruggiero, Raul Alejandro   +3 more
core   +1 more source

Does asymptomatic primary tumor need to be removed in unresectable metastatic colon cancer?

Тазовая хирургия и онкология, 2015
Every third colorectal cancer patient has inoperable metastatic disease upon diagnosis. And quite often the primary tumor is asymptomatic. The question stands for surgeon and medical oncologist, whether to proceed with upfront surgery or systemic ...
M. Yu. Fedyanin, A. A. Tryakin, S. A. Tyulyandin   +2 more
doaj   +1 more source

Bortezomib Augments Natural Killer Cell Targeting of Stem-Like Tumor Cells. [PDF]

, 2019
Tumor cells harboring stem-like/cancer stem cell (CSC) properties have been identified and isolated from numerous hematological and solid malignancies.
Ames, Erik, Bouzid, Lyes A, Canter, Robert J, Darrow, Morgan A, Grossenbacher, Steven K, Judge, Sean J, Luna, Jesus I, Murphy, William J, Sturgill, Ian R   +8 more
core   +1 more source