Results 171 to 180 of about 150,567 (245)

Architectural and evolutionary features of TE-derived TSSs shape tissue-specific promoter activity in the human genome. [PDF]

Nat Commun
Zhang Y, Fan Y, Wu H, Zhang XO.
europepmc   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Resolution of a human chromosomal mystery: Evolutionary complexity revealed. [PDF]

Cell Genom
Rogers J.
europepmc   +1 more source

Untargeted Metabolomics Identifies N‐Lactoyl‐Amino Acids as Dose‐Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

Clinical Pharmacology &Therapeutics, EarlyView.
Metformin is the most widely prescribed antidiabetic drug, yet adherence remains difficult to objectively assess. Using untargeted metabolomics and lipidomics, we analyzed plasma from 637 patients with type 2 diabetes (T2D) with confirmed metformin use and 143 nondiabetic controls, annotating 614 metabolites.
Tomas Cajka, Jiri Hricko, Lucie Rudl Kulhava, Michaela Paucova, Michaela Novakova, Veronika Hola, Stanislava Rakusanova, Oliver Fiehn, Vojtech Skop, Ivana Lankova, Iva Miskova, Terezie Pelikanova, Martin Haluzik   +12 more
wiley   +1 more source

Probing the staying power of chemogenetics. [PDF]

Elife
Puchik M, Kagan I.
europepmc   +1 more source

Rodent monocyte‐derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians

Developmental Dynamics, EarlyView.
Abstract Background CD163 is a scavenger receptor predominantly expressed on the surfaces of macrophages in various mammalian species and is a marker of anti‐inflammatory (M2‐like) macrophages. High density of CD163‐positive tumor‐associated macrophages (TAMs) is associated with worse prognosis in various patient tumors.
Yoichi Saito, Yukio Fujiwara, Yasuka L. Yamaguchi, Satomi S. Tanaka, Kyoko Miura, Yoshiyuki Hizukuri, Kyoko Yamashiro, Yasuhiro Hayashi, Yuta Nakashima, Yoshihiro Komohara   +9 more
wiley   +1 more source

Optical tissue clearing and 3D imaging of intact primate testicular tissue: a novel technology development. [PDF]

PLoS One
Kibui PW, Weischer S, von Ostau N, Hess J, Kirschnick N, Zobel T, Schlatt S.   +6 more
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Evolutionary convergence and divergence of hippocampal cytoarchitecture between rodents and primates revealed by single-cell spatial transcriptomics. [PDF]

Natl Sci Rev
Fei T, Dong Y, Gou X, Zhang J, Wang G, Yuan N, Zhuang Z, Chen D, Wu Z, Zhan L, Liang N, Mitsios N, Pan J, Zhan Y, Cao M, Xia Y, Yan H, Zhu X, Huang Y, Chen S, Yang H, Gu L, Wang H, Zhong Y, Yu Q, An Y, Wang R, Li S, Song J, Zhou W, Zhang S, Ren B, Lu Y, Ding W, Li S, Cao H, Lin J, Dou Y, Jiang X, Xie C, Li Y, Tan X, Xu Y, Song X, Li H, Chen M, Wang S, Zheng M, Fang J, Zhang R, Chai Q, Wang M, Li L, Gao T, Qian L, Jin C, Huang J, Deng W, Li M, Li C, Liu Z, Liang Z, Xu S, Uhlén M, Poo MM, Yao J, Liu S, Liu C, Shen Z, Sun YG, Li CT, Mulder J, Cao G, Sun Y, Xu C.   +74 more
europepmc   +1 more source

On the Verge of Exclusion: The Unique Psychological Profile of the Threat of Social Exclusion

European Journal of Social Psychology, EarlyView.
ABSTRACT Past research, often using Cyberball—an online ball‐tossing game with two or more preprogrammed players—showed that being socially excluded produces various negative emotions and lower need satisfaction. However, in everyday life, people may experience the threat of social exclusion more frequently than actual exclusion. Across two experiments
Tiara R. Widiastuti, Hein T. van Schie, Ilja van Beest, Johan C. Karremans   +3 more
wiley   +1 more source