Results 181 to 190 of about 154,066 (268)

Visualizing Specific Tubulin Isotypes and Pathogenic Variants in Cellular Microtubule Arrays

Cytoskeleton, EarlyView.
ABSTRACT Eukaryotic cells depend on dynamic microtubule arrays to execute a wide range of functions vital for life. These microtubule filaments are formed through the polymerization of α/β‐tubulin proteins, which can be generated from numerous tubulin genes, or isotypes.
Sareen Fiaz, Benjamin Powers, Jayne Aiken   +2 more
wiley   +1 more source

Evolutionary echoes of emotion: Humans mimic other primate expressions. [PDF]

PLoS One
Hess U, Kastendieck T, Erkol MG, Mauersberger H, Davila-Ross M, Liebal K, Palagi E.   +6 more
europepmc   +1 more source

Pediatric Developmental Safety Assessment: Are We Ready for the Next Thalidomide?

Clinical Pharmacology &Therapeutics, EarlyView.
Pediatric drug development has achieved remarkable success in the last 20 years with over 1,000 products studied in pediatric patients. This success has been driven in part by an increased understanding of pediatric disease processes. The aspect that has been largely overlooked is the potential adverse effect of new drugs on pediatric developmental ...
Gilbert J. Burckart, Susan M. Abdel‐Rahman, Gelareh Abulwerdi, Sherbet Samuels, Rebecca Racz, Mohamed A. Mohamoud, Nicholas P. Tatonetti   +6 more
wiley   +1 more source

Liver Xenotransplantation: From Early Primate Trials to the First-in-Human Porcine Bridging Therapies. [PDF]

J Clin Med
Nastase AG, Vasilescu AM, Trofin AM, Iftimie NF, Segura-Sampedro JJ, Cadar R, Buzincu I, Davidescu A, Nastase AL, Briceanu OG, Lupascu-Ursulescu C, Lupascu CD.   +11 more
europepmc   +1 more source

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Beyond primates: exploring the potential role of other mammalian hosts in yellow fever virus ecology. [PDF]

New Microbes New Infect
Bonilla-Aldana DK, Bonilla-Aldana JL, Sanchez-Rojas IC, Rodriguez-Morales AJ.   +3 more
europepmc   +1 more source

Preserved Spermatogenesis and Hormonal Function in Men Receiving a Pretomanid Regimen (BPaMZ) for Pulmonary Drug‐Resistant Tuberculosis

Clinical Pharmacology &Therapeutics, EarlyView.
Pretomanid is a component of the World Health Organization‐recommended treatment regimen for drug‐resistant tuberculosis in patients aged ≥ 14 years. While preclinical rodent studies identified testicular toxicity as a potential clinical liability at elevated doses, no corresponding effects were observed in nonhuman primates nor clinical hormone ...
Pauline Howell, Antonio Lombardi, William Brumskine, Lali Mikiashvili, Kim Boekelheide, Joanna Moreira, Alda Holsta, Matthew Betteridge, Lindsay Thompson, Angela Crook, Paul Bruinenberg, Maria Beumont, Eugene Sun, Francesca Conradie   +13 more
wiley   +1 more source

Filter, Detector, Predictor: The expanding repertoire of retinal computation in vertebrates. [PDF]

Vision Res
Manookin MB, Rieke F.
europepmc   +1 more source

Relationship between home range and population density in mammals: the role of sociality, territoriality and habitat dimensionality

Ecography, EarlyView.
Organisms' energy requirements increase with body mass, leading to larger home range areas and lower population density. Previous research has highlighted the differential scaling of these variables in mammals, where species with large home ranges have higher density than expected due to increased home range overlap. Here we investigate this phenomenon
Luca Santini, Gianni Jacucci, Marlee A. Tucker   +2 more
wiley   +1 more source

Food culture as a mechanism of social bonding and social identity in primates. [PDF]

Front Hum Neurosci
Roberts AI, Roberts SGB.
europepmc   +1 more source