Results 221 to 230 of about 361,700 (307)

A Systematic Review on Disease‐Modifying Therapies in Parkinsonian Disorders

Clinical Pharmacology &Therapeutics, EarlyView.
Parkinsonian disorders, including Parkinson's disease, Lewy body dementia, multiple system atrophy, and progressive supranuclear palsy, are progressive neurodegenerative conditions with no treatment options to slow disease progression. This systematic review provides an overview of evidence of disease‐modifying therapies that have been evaluated in ...
Pepijn P.N.M. Eijsvogel, Lars M.G. Smits, Philip H.C. Kremer, Geert Jan Groeneveld   +3 more
wiley   +1 more source

Age-associated hematopoietic variants in the rhesus macaque. [PDF]

Blood Adv
De La Fuente J, Kapadia CD, Harris RA, Raveendran M, Diniz GB, Morrison JH, Rogers J, Goodell MA.   +7 more
europepmc   +1 more source

Relationship between home range and population density in mammals: the role of sociality, territoriality and habitat dimensionality

Ecography, EarlyView.
Organisms' energy requirements increase with body mass, leading to larger home range areas and lower population density. Previous research has highlighted the differential scaling of these variables in mammals, where species with large home ranges have higher density than expected due to increased home range overlap. Here we investigate this phenomenon
Luca Santini, Gianni Jacucci, Marlee A. Tucker   +2 more
wiley   +1 more source

VDJ-Insights: simplifying the annotation of genomic immunoglobulin and T cell receptor regions. [PDF]

Bioinformatics
Ott SE, Le GN, Mohammadi SJ, Mittertreiner J, Pasini EM, Bontrop RE, de Groot NG, Bruijnesteijn J.   +7 more
europepmc   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

On the Verge of Exclusion: The Unique Psychological Profile of the Threat of Social Exclusion

European Journal of Social Psychology, EarlyView.
ABSTRACT Past research, often using Cyberball—an online ball‐tossing game with two or more preprogrammed players—showed that being socially excluded produces various negative emotions and lower need satisfaction. However, in everyday life, people may experience the threat of social exclusion more frequently than actual exclusion. Across two experiments
Tiara R. Widiastuti, Hein T. van Schie, Ilja van Beest, Johan C. Karremans   +3 more
wiley   +1 more source

Carbon and Nitrogen Stable Isotopic Profiling of Chimpanzees and Monkeys in Kalinzu Forest Reserve, Uganda. [PDF]

Am J Primatol
Tsutaya T, Aruga N, Ishikawa NF, Sasaki Y, Kitayama H, Yoneda M, Ogawa NO, Ohkouchi N, Hashimoto C.   +8 more
europepmc   +1 more source

Pediatric sensorimotor cortical responsiveness to intracerebral stimulation during stereoelectroencephalographic monitoring: Age effects and area specificity

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to determine how age influences clinical responsiveness to intracerebral electrical stimulation (IES) in children across primary and secondary sensorimotor cortices and to assess age effects on response complexity and area‐specific responsiveness.
Giulia Nobile, Laura Tassi, Marta Ponzano, Piergiorgio d'Orio, Alessandro Consales, Luca Bosisio, Stefano Francione, Gabriele Arnulfo, Maria Pia Sormani, Lino Nobili, Roberto Mai   +10 more
wiley   +1 more source

Metabolism Controls the Timing of Human Brain Development and Maturation. [PDF]

J Inherit Metab Dis
Rava V, Cannone E, Francolini M, Taverna E.   +3 more
europepmc   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source