Results 31 to 40 of about 154,066 (268)

Generation and functional characterization of tuft cells in non-human primate pancreatic ducts through organoid culture systems

Frontiers in Cell and Developmental Biology
The pancreatic duct plays a key role in collecting pancreatic juice, which is rich in digestive enzymes. The fluid flows unidirectionally into the duodenum, where it mixes with partially digested food to further facilitate digestion.
Kosuke Sakaguchi, Chiemi Kimura-Nakajima, Akihiko Inaba, Yoshiko Hatano, Hanako Ogawa, Yuichi Koshiishi, Keisuke Tanaka, Tatsuya Kometani, Makoto Ohmoto, Koji Sato, Hiroo Imai, Ken Iwatsuki   +11 more
doaj   +1 more source

Localization of multiple pleiotropic genes for lipoprotein metabolism in baboons[S]

Journal of Lipid Research, 2009
We employed a novel approach to identify the key loci that harbor genes influencing lipoprotein metabolism in approximately 2,000 pedigreed baboons fed various diets differing in levels of fat and cholesterol.
David L. Rainwater, Laura A. Cox, Jeffrey Rogers, John L. VandeBerg, Michael C. Mahaney   +4 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Primates chunk simultaneously-presented memoranda

Frontiers in Behavioral Neuroscience, 2022
Though much research has characterized both the behavior and electrophysiology of spatial memory for single targets in non-human primates, we know much less about how multiple memoranda are handled. Multiple memoranda may interact in the brain, affecting
Charles D. Holmes, Charles D. Holmes, ShiNung Ching, Lawrence H. Snyder, Lawrence H. Snyder   +4 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Historical Demography and Species Distribution Models Shed Light on Speciation in Primates of Northeast India

Ecology and Evolution
Past climate change is one of the important factors influencing primate speciation. Populations of various species could have risen or declined in response to these climatic fluctuations.
Mihir Trivedi, Kunal Arekar, Shivakumara Manu, Lukas F. K. Kuderna, Jeffrey Rogers, Kyle Kai‐How Farh, Tomas Marques Bonet, Govindhaswamy Umapathy   +7 more
doaj   +1 more source

Analysis of Streptococcus dysgalactiae subspecies equisimilis gene transcripts during experimental primate necrotizing myositis

mBio
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a gram-positive bacterial pathogen capable of causing various infections in humans. Recently, isolates of SDSE emm type stG62647 have emerged as a cause of severe invasive infections, including ...
Jesus M. Eraso, Randall J. Olsen, S. Wesley Long, Ahmad Faili, Samer Kayal, James M. Musser   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pathogenesis and Animal Models of Post-Primary (Bronchogenic) Tuberculosis, A Review

Pathogens, 2018
Primary and post-primary tuberculosis (TB) are different diseases caused by the same organism. Primary TB produces systemic immunity. Post-primary TB produces cavities to support massive proliferation of organisms for transmission of infection to new ...
Robert L. Hunter, Jefrey K. Actor, Shen-An Hwang, Arshad Khan, Michael E. Urbanowski, Deepak Kaushal, Chinnaswamy Jagannath   +6 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source