Results 41 to 50 of about 361,700 (307)

Historical Demography and Species Distribution Models Shed Light on Speciation in Primates of Northeast India

Ecology and Evolution
Past climate change is one of the important factors influencing primate speciation. Populations of various species could have risen or declined in response to these climatic fluctuations.
Mihir Trivedi, Kunal Arekar, Shivakumara Manu, Lukas F. K. Kuderna, Jeffrey Rogers, Kyle Kai‐How Farh, Tomas Marques Bonet, Govindhaswamy Umapathy   +7 more
doaj   +1 more source

Analysis of Streptococcus dysgalactiae subspecies equisimilis gene transcripts during experimental primate necrotizing myositis

mBio
Streptococcus dysgalactiae subspecies equisimilis (SDSE) is a gram-positive bacterial pathogen capable of causing various infections in humans. Recently, isolates of SDSE emm type stG62647 have emerged as a cause of severe invasive infections, including ...
Jesus M. Eraso, Randall J. Olsen, S. Wesley Long, Ahmad Faili, Samer Kayal, James M. Musser   +5 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Pathogenesis and Animal Models of Post-Primary (Bronchogenic) Tuberculosis, A Review

Pathogens, 2018
Primary and post-primary tuberculosis (TB) are different diseases caused by the same organism. Primary TB produces systemic immunity. Post-primary TB produces cavities to support massive proliferation of organisms for transmission of infection to new ...
Robert L. Hunter, Jefrey K. Actor, Shen-An Hwang, Arshad Khan, Michael E. Urbanowski, Deepak Kaushal, Chinnaswamy Jagannath   +6 more
doaj   +1 more source

Rate variation during molecular evolution: creationism and the cytochrome c molecular clock [PDF]

, 2017
Molecular clocks based upon amino acid sequences in proteins have played a major role in the clarification of evolutionary phylogenies. Creationist criticisms of these methods sometimes rely upon data that might initially seem to be paradoxical.
Hofmann James, R.
core   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cortisol predicts increased internal capsule integrity in a large sample of non-human primates

European Journal of Psychotraumatology, 2012
Background : Cortisol is critical for survival and reflects a primary mechanism by which emotions can influence immune responses throughout the periphery.
Do P.M. Tromp, Andrew S. Fox, Jonathan A. Oler, Nagesh Adluru, Richard J. Davidson, Andrew L. Alexander, Ned H. Kalin   +6 more
doaj   +1 more source

Optogenetics in primates: monkey see monkey look [PDF]

, 2011
Optogenetics has emerged as a powerful tool for studying the neural basis of simple behaviors in rodents and small animals. In the primate model, however, optogenetics has had limited utility because optical methods have not been able to drive behavior ...
Gregory Horwitz, Mehrdad Jazayeri, Zachary Lindbloom-Brown   +2 more
core   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Seasonal Adaptation of the Gut Microbiome in Japanese Macaques: Linking Gut Microbiome Shifts With Fermentative Function

Ecology and Evolution
Seasonal fluctuations in food availability strongly influence the ecology of wild mammals, yet the role of the gut microbiome in mediating these challenges remains insufficiently explored.
Wanyi Lee, Tianmeng He, Yosuke Kurihara, Izumi Shiroishi, Kazunari Ushida, Sayaka Tsuchida, Goro Hanya   +6 more
doaj   +1 more source