Results 131 to 140 of about 217,641 (208)

The Development and Challenges of PET/MRI Dual‐Modality Imaging Probes—An Update

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT The integration of Positron emission tomography (PET) with Magnetic resonance imaging (MRI) combines the functional imaging capabilities of PET with the high‐resolution anatomical detail of MRI, creating a synergistic platform for advanced diagnostic imaging and image‐guided therapies. Central to the success of this dual‐modality system is the
Maryam Sabbaghan, Saumya Nigam, Isabella Kasabasic, Medha Manepalli, Ping Wang, Jinda Fan   +5 more
wiley   +1 more source

MR‐Guidance of Gene Therapy for Brain Diseases: Moving From Palliative Treatment to Cures

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Regulatory bodies in the U.S. and Europe recently approved a gene therapy for aromatic L‐amino acid decarboxylase (AADC) deficiency, a rare neurologic disorder where a genetic mutation prevents dopamine production in the brain. Affected children fail to develop normal motor and cognitive functions.
Dalton H. Bermudez, Thomas Lilieholm, Walter F. Block   +2 more
wiley   +1 more source

Assessing the Acoustic Landscape and Vegetational Structure of a Mining Area Undergoing Restoration for Over 30 Years

Land Degradation &Development, EarlyView.
ABSTRACT Mining causes substantial changes in urban and natural ecosystems, making land restoration an essential step along the mining process and after mine closure. Here, we elucidate the soundscape and vegetation structure of a recently closed mine site under restoration over the past 30 years.
Bruna Marcela Teixeira de Andrade, Juliana Carneiro de Lacerda, Barbara Lins Caldas de Moraes, Antônio Robério Freire‐Filho, e Bruna Bezerra   +4 more
wiley   +1 more source

The Gut‐Brain Axis in Parkinson disease: Emerging Concepts and Therapeutic Implications

Movement Disorders Clinical Practice, EarlyView.
Abstract Background The gut‐brain axis, i.e. the bidirectional communication system between the gut and the brain, has become of central importance in Parkinson disease (PD) research over the past 20 years. Aims We aimed to describe the milestones of the gut‐brain axis research in PD and the development of theories proposing the involvement of the ...
Elisa Menozzi, Anthony H.V. Schapira, Per Borghammer   +2 more
wiley   +1 more source

Fist‐Palm Test May Identify Mild Cognitive Impairment and Freezing of Gait in Parkinson's Disease: A Machine Learning Approach

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Mild cognitive impairment (MCI) and freezing of gait (FOG) are two common symptoms in Parkinson's disease (PD). Objectives The objectives were to test the strength of association of fist‐palm test (FiPaT), a nonverbal motor test, with both MCI and FOG in PD and investigate the predictive ability of FiPaT in the identification of PD ...
Sofia Cuoco, Michela Russo, Carlo Ricciardi, Beatrice D'Arco, Cristiano Sorrentino, Arianna Cappiello, Maria Romano, Francesco Amato, Marco Aiello, Roberto Erro, Marianna Amboni, Paolo Barone   +11 more
wiley   +1 more source

Transcranial Temporal Interference Stimulation of the Right Globus Pallidus in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Invasive deep brain stimulation (DBS) has been shown to be effective in treating patients with Parkinson's disease (PD), yet its clinical use is limited to patients at the advanced stage of the disease. Transcranial temporal interference stimulation (tTIS) may be a novel nonneurosurgical and safer alternative, yet its therapeutic ...
Chenhao Yang, Yongxin Xu, Xiaofan Feng, Bowen Wang, Yichao Du, Kexin Wang, Jiaojiao Lü, Lingyan Huang, Zhenyu Qian, Zhen Wang, Nan Chen, Junhong Zhou, Chencheng Zhang, Yu Liu   +13 more
wiley   +1 more source

Noninvasive Temporal Interference Stimulation of the Subthalamic Nucleus in Parkinson's Disease Reduces Beta Activity

Movement Disorders, EarlyView.
Abstract Background Temporal interference stimulation (TIS) is a novel noninvasive electrical stimulation technique to focally modulate deep brain regions; a minimum of two high‐frequency signals (f1 and f2 > 1 kHz) interfere to create an envelope‐modulated signal at a deep brain target with the frequency of modulation equal to the difference frequency:
Martin Lamoš, Martina Bočková, Florian Missey, Claudia Lubrano, Mariane de Araújo e Silva, Jan Trajlínek, Ondřej Studnička, Pavel Daniel, Romain Carron, Viktor Jirsa, Jan Chrastina, Radim Jančálek, Eric Daniel Glowacki, Antonino Cassara, Esra Neufeld, Irena Rektorová, Adam Williamson   +16 more
wiley   +1 more source

Long‐Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients

Movement Disorders, EarlyView.
Abstract Background Subthalamic beta oscillations are a biomarker for bradykinesia and rigidity in Parkinson's disease (PD), incorporated as a feedback signal in adaptive deep brain stimulation with potential for guiding electrode contact selection.
Jennifer K. Behnke, Robert L. Peach, Jeroen G.V. Habets, Johannes L. Busch, Jonathan Kaplan, Jan Roediger, Varvara Mathiopoulou, Lucia K. Feldmann, Moritz Gerster, Juliette Vivien, Gerd‐Helge Schneider, Katharina Faust, Patricia Krause, Andrea A. Kühn   +13 more
wiley   +1 more source

Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2–Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputaminal infusion in participants with advanced Parkinson's disease (PD) achieved 26% mean putaminal coverage ...
Amber D. Van Laar, Chadwick W. Christine, Nicolás Phielipp, Paul S. Larson, J. Bradley Elder, Aristide Merola, Waldy San Sebastian, Massimo S. Fiandaca, Adrian P. Kells, Michael E. Wisniewski, Krystof S. Bankiewicz   +10 more
wiley   +1 more source

Cholinergic System Changes in Dopa‐Unresponsive Freezing of Gait in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background Freezing of gait (FoG) is a debilitating mobility disturbance that becomes increasingly resistant to dopaminergic pharmacotherapies with advancing Parkinson's disease (PD). The pathophysiology underlying the response of FoG to dopaminergic treatment is poorly understood.
Kelvin L. Chou, Prabesh Kanel, Miriam van Emde Boas, Stiven Roytman, Giulia Carli, Roger L. Albin, Nicolaas I. Bohnen   +6 more
wiley   +1 more source