Results 131 to 140 of about 492,641 (339)
, 2013 An influential position in linguistics is that human language has not evolved primarily as a communication device, but as a “system of thought.” This system enables humans to refer to the outside world in ways that cannot be reduced to a “peculiar nature belonging to [a] thing” and to construct an infinite number of internal structures by merging ...
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Advanced Science, EarlyView.This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu +6 more
wiley +1 more source
Digitized Fossil Brains: Neocorticalization
Biolinguistics, 2012 This report is based on 3D digital scans of endocasts of 110 species of fossil mammals and 35 species of living mammals. It presents direct evidence of the last 60 million years of brain evolution. Endocasts are casts of the cranial cavity.
Harry J. Jerison
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The physiology and neurochemistry of self-injurious behavior: a nonhuman primate model [PDF]
, 2005 Tiefenbacher Stefan
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Advanced Science, EarlyView.SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li +14 more
wiley +1 more source
Advanced Science, EarlyView.This study demonstrates meningeal lymphatic impairment associated with lung adenocarcinoma brain metastasis progression in both human patients and mouse models, establishes clinically applicable non‐invasive imaging biomarkers for quantitative analyzing mLV structure and function, and reveals mLVs as robust prognostic indicators and promising potential
Yuan Zhang +15 more
wiley +1 more source
Primates watching primates watching primates: Why do we anthropomorphise?
, 2021 Anthropomorphism is the attribution of human traits, capacities, or mental states to non-human animals. Numerous factors likely affect our tendency to anthropomorphise (TA). Previous studies, using questionnaire methods found increased TA with phylogenetic distance to other species, while empathy and compassion decreased.
Milidakis, Margarita Artemis +4 more
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Advanced Science, EarlyView.Magnetoelectric nanoparticles (MENPs) serve as externally controlled, MRI‐activated theranostic agents for targeted cancer therapy by inducing electric field‐based ablation in solid tumors. MENPs enable simultaneous precise tumor ablation and MRI signal modulation, allowing real‐time treatment monitoring and prediction of therapeutic outcomes with no ...
John Michael Bryant +28 more
wiley +1 more source
Comparative Single‐Cell Transcriptomic Atlas Reveals the Genetic Regulation of Reproductive Traits
Advanced Science, EarlyView.A cross‐species single‐cell transcriptomic atlas of reproductive and central nervous system tissues from sheep and humans reveals conserved cellular programs and regulatory networks that regulated fertility. Integration with GWAS for sheep lifetime average litter size identifies UNC5–SLIT–BMP signaling as a core pathway coordinating neuroendocrine ...
Bingru Zhao +8 more
wiley +1 more source
Non-human primate models: artificial menstrual cycles, endometrial matrix metalloproteinases and s.c. endometrial grafts [PDF]
, 1996 Robert Brenner +3 more
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