Results 141 to 150 of about 217,641 (208)

Corticospinal Tract Development, Evolution, and Skilled Movements

Movement Disorders, EarlyView.
Abstract The evolution of the corticospinal tract (CST) is closely linked to the development of skilled voluntary movements in mammals. The main evolutionary divergence concerns the position of the CST within the spinal cord white matter and its postsynaptic targets in the grey matter.
Emmanuel Roze, Caroline Dubacq, Quentin Welniarz   +2 more
wiley   +1 more source

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Nonlocal Cooperative Behavior, Psychological Effects, and Collective Decision‐Making: An Exemplification With Predator–Prey Models

Mathematical Methods in the Applied Sciences, EarlyView.
ABSTRACT In bio‐social models, cooperative behavior has evolved as an adaptive strategy, playing multi‐functional roles. One of such roles in populations is to increase the success of the survival and reproduction of individuals and their families or social groups.
Sangeeta Saha, Swadesh Pal, Roderick Melnik   +2 more
wiley   +1 more source

Orangutans in perspective: Forced copulations and female mating resistance [PDF]

, 2007
Kahlenberg, Sonya, Knott, Cheryl D.
core  

The NLRP3 inhibitor NT‐0796 enhances and sustains GLP‐1R agonist‐mediated weight loss in a murine diet‐induced obesity model

Obesity, EarlyView.
In mouse diet‐induced obesity models, the brain penetrant NLRP3 inhibitor NT‐0796 enhances and sustains the efficacy of the GLP‐1RA semaglutide, leading to a complete reversal of obesity. This correlates with reduced peripheral inflammation and anti‐neuroinflammatory activities, including a reduction in hypothalamic gliosis suggesting further benefits ...
Peter Thornton, Valérie Reader, Zsofia Digby, John Doedens, Nicola Lindsay, Nicholas Clarke, Alan P. Watt   +6 more
wiley   +1 more source

Dietary macronutrient content and energy intake in the mouse: hedonic or homeostatic override?

Obesity, EarlyView.
Abstract Objective The objective of this study was to reconcile how two landmark mouse studies came to opposite conclusions regarding the relationship between dietary macronutrient composition and energy intake. Hu et al. concluded that dietary fat drives excess energy intake because its hedonic properties override energy homeostasis. Solon‐Biet et al.
Stephen J. Simpson, Alistair M. Senior, Samantha M. Solon‐Biet, David G. Le Couteur, David Raubenheimer   +4 more
wiley   +1 more source

Relatedness, trait evolution, and climatic niche divergence in mammalian island endemics

Oikos, EarlyView.
Island mammals have influenced ecological and evolutionary theory since Darwin, and many of them provide textbook examples of the dramatic morphological evolution that often occurs in island communities. However, patterns of evolution in the climatic niches of island mammals have yet to be fully explored.
Benjamin R. Shipley, Neha Shah, Jenny L. McGuire   +2 more
wiley   +1 more source

Conserving wildlife through demand reduction and supply alternatives: Two experiments in restaurants in Kinshasa

People and Nature, EarlyView.
Abstract High aggregate levels of wildlife consumption in cities in Central Africa highlight the need for solutions that balance wildlife protection, local livelihoods and the relational values between people and nature. This study explores the impacts of demand‐ and supply‐side interventions on wild meat consumption through two randomized control ...
Abdoulaye Cisse, Gabriel Englander, Daniel J. Ingram   +2 more
wiley   +1 more source

The TBXT rs2305089 SNP links the benign notochordal cell tumour and chordoma

The Journal of Pathology, EarlyView.
Abstract The aim of this research was to investigate the pathogenesis of the bone cancer chordoma and the role of the germline rs2305089 SNP in TBXT. Using medical imaging and genotyping studies, we observed that benign notochordal cell tumours (BNCTs) were associated with chordomas and with the variant rs2305089 A‐allele with enrichment of the AA ...
Inga Usher, Paul O'Donnell, Lorena Ligammari, Dorothee Harder, Wendy Brown, David Choi, Paul Cool, Lucia Cottone, Adrienne M Flanagan   +8 more
wiley   +1 more source

Interactions of Therapeutic Antibodies With Presynaptically‐Released Misfolded Proteins in Neurodegenerative Diseases. A Spatial Monte‐Carlo Simulation Study

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT The spatial progression hypothesis of misfolded tau and alpha‐synuclein proteins in Alzheimer's and Parkinson's Disease proposes the release of proteins from a presynaptic membrane followed by diffusion over the synaptic cleft and uptake by the postsynaptic membrane in the afferent neuron.
Jamie Goff, Maryam Khalifa, Shaina M. Short, Piet H. van der Graaf, Hugo Geerts   +4 more
wiley   +1 more source