Results 21 to 30 of about 209,923 (218)

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Engineering Concentration‐Dependent Intravitreal Mobility via Cyclic Arginine‐Enriched Nanocarrier Surface Modification: In Vivo Proof‐of‐Concept in a Porcine Large Animal Model

Advanced Healthcare Materials, EarlyView.
In this study, Hammer et al. highlight cyclic‐arginine surface engineering as a highly biocompatible, controllable, and concentration‐dependent regulator of intravitreal nanoparticle mobility in vivo in a translational large animal model. The cyclic arginine surface‐modification supports the development of next‐generation biomaterials for long‐acting ...
Maximilian Hammer, Bryan Calder Ackermann, Anna Stoß, Niklas Junker, Ludwig Geisweid, Sabrina Wohlfart, Jonathan Herth, Simon William Pohl, Manuel Ben Böhmann, André Schulz, Victor Aristide Augustin, Gerd Uwe Auffarth, Philipp Uhl   +12 more
wiley   +1 more source

The Internal, External and Extended Microbiomes of Hominins

Frontiers in Ecology and Evolution, 2020
The social structure of primates has recently been shown to influence the composition of their microbiomes. What is less clear is how primate microbiomes might in turn influence their social behavior, either in general or with particular reference to ...
Robert R. Dunn, Robert R. Dunn, Katherine R. Amato, Elizabeth A. Archie, Mimi Arandjelovic, Alyssa N. Crittenden, Lauren M. Nichols   +6 more
doaj   +1 more source

A generalizable brain extraction net (BEN) for multimodal MRI data from rodents, nonhuman primates, and humans

eLife, 2022
Accurate brain tissue extraction on magnetic resonance imaging (MRI) data is crucial for analyzing brain structure and function. While several conventional tools have been optimized to handle human brain data, there have been no generalizable methods to ...
Ziqi Yu, Xiaoyang Han, Wenjing Xu, Jie Zhang, Carsten Marr, Dinggang Shen, Tingying Peng, Xiao-Yong Zhang, Jianfeng Feng   +8 more
doaj   +1 more source

Decoupling Photochemical and Photothermal Effects Using Molecular Motors Enables Fast, Intelligent, and Life‐Like Motions in Soft Materials

Advanced Materials, EarlyView.
A light‐responsive liquid crystal (LC) polymer network integrating molecular rotary motors and photothermal converters enables the decoupling of photochemical and photothermal effects. Selective wavelength activation allows orthogonal control over persistent shape encoding and fast reversible motion, enabling programmable soft robots capable of complex
Guiying Long, Jinyu Sheng, Alexander Ryabchun, Ben L. Feringa   +3 more
wiley   +1 more source

Network analysis highlights socio-demographic patterns of stone tool-using primates

Scientific Reports
While the nutritional benefits and social learning of tool use in primates have been widely studied, far less is known about how tool use is associated with social life. We investigated the social aspects of tool use in a hybrid population of long-tailed
Gwennan T. L. Giraud, Theo D. R. O’Malley, Jonathan S. Reeves, Amanda Tan, Sebastian Sosa, Suchinda Malaivijitnond, Lydia V. Luncz   +6 more
doaj   +1 more source

Road Infrastructure and Primate Conservation: Introducing the Global Primate Roadkill Database

Animals, 2023
As road infrastructure networks rapidly expand globally, especially in the tropics, previously continuous habitats are being fragmented, resulting in more frequent wildlife–vehicle collisions (WVC).
Laura C. Praill, Timothy M. Eppley, Sam Shanee, Pamela M. K. Cunneyworth, Fernanda D. Abra, Néstor Allgas, Hassan Al-Razi, Marco Campera, Susan M. Cheyne, Wendy Collinson, Giuseppe Donati, Birthe Linden, Sophie Manson, Marjan Maria, Thais Q. Morcatty, K. A. I. Nekaris, Luciana I. Oklander, Vincent Nijman, Magdalena S. Svensson   +18 more
doaj   +1 more source

Collision‐Resilient Winged Drones Enabled by Tensegrity Structures

Advanced Robotics Research, EarlyView.
Based on structures of birds such as the woodpeck, this article presents the collision‐resilient aerial robot, SWIFT. SWIFT leverages tensegrity structures in the fuselage and wings which allow it to undergo large deformations in a crash, without sustaining damage. Experiments show that SWIFT can reduce impact forces by 70% over conventional structures.
Omar Aloui, Raphael Zufferey, William Stewart, Mohammad Askari, Simon Jeger, Dario Floreano   +5 more
wiley   +1 more source

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling

Advanced Science, EarlyView.
IGFBP4 is upregulated in granulosa cells of aged ovaries across monkeys, mice, and humans. It inhibits YAP signaling, thereby suppressing cell proliferation and contributing to follicular dysfunction. Deletion of Igfbp4 in granulosa cells enhances ovulatory output, improves hormone profiles, and reproductive performance in aged female mice, suggesting ...
Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li   +8 more
wiley   +1 more source

The Influence of a Memory Delay on Spatial Coding in the Superior Colliculus: Is Visual Always Visual and Motor Always Motor?

Frontiers in Neural Circuits, 2018
The memory-delay saccade task is often used to separate visual and motor responses in oculomotor structures such as the superior colliculus (SC), with the assumption that these same responses would sum with a short delay during immediate “reactive ...
Morteza Sadeh, Morteza Sadeh, Morteza Sadeh, Morteza Sadeh, Morteza Sadeh, Amirsaman Sajad, Amirsaman Sajad, Amirsaman Sajad, Amirsaman Sajad, Hongying Wang, Hongying Wang, Xiaogang Yan, Xiaogang Yan, John Douglas Crawford, John Douglas Crawford, John Douglas Crawford, John Douglas Crawford, John Douglas Crawford   +17 more
doaj   +1 more source