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A prime–boost vaccination of mice with heterologous H5N1 strains
Vaccine, 2009We evaluated the priming effect of an H5N1 pandemic vaccine in a mouse model to investigate strategies for influenza pandemic vaccination. For priming, an alum-adjuvanted inactivated whole H5N1 vaccine (NIBRG-14, clade 1) was used. As booster vaccines, several formulations of Indo05/05/2005(H5N1)PR8-IBCDC-RG2 vaccines (clades 2-1)were evaluated ...
Daisuke, Ikeno +7 more
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Prime–boost strategies to embrace diversity and inclusion in immunology
Nature Reviews Immunology, 2016Immunologists appreciate the need for creative approaches to tackle complex scientific questions, which can involve not only the use of novel technologies but also the experience of scientists from diverse backgrounds. Here, we highlight measures to prime for the inclusion of women and underrepresented individuals in science to boost immunology ...
Cherie L, Butts +2 more
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Heterologous Prime-Boost Vaccination in Tumor Immunotherapy
2004Most of the vaccine strategies under development use multiple immunizations with the same agent such as a viral vector encoding a tumor antigen. More recently, the concept of heterologous prime-boost immunization has been tested in animal models. This strategy involves the sequential administration of different delivery vectors encoding the same ...
Michael J. Palmowski, Caroline Smith
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Prime-boost malaria vaccine in field trial
The Lancet Infectious Diseases, 2002The first field trial of a new prime-boost malaria immunisation programme is underway in The Gambia. The strategy involves two different vaccines: a DNA vaccine and a recombinant viral vaccine, modified vaccinia virus Ankara (MVA). Both contain a DNA sequence encoding the thrombospondin-related adhesion protein (TRAP), a protein seen on the surface of ...
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Toward a prime-boost regime for NK cells?
Blood, 2012In this issue of Blood , Romee et al report a novel strategy for triggering memory-like NK-cell responses with implications for NK cell–based immunotherapy.[1][1] Although natural killer (NK) cells were identified more than 30 years ago based on their ability to kill tumor cells in the absence ...
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Prime boost vaccines power up in people
Nature Medicine, 2003Vaccines using DNA for priming and recombinant modified vaccinia Ankara virus (MVA) for boosting have shown great promise in preclinical models. Now, this novel protocol appears effective in humans ( pages 729–735 ).
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MCED Blood Test Boosts Cancer Detection in Symptomatic Patients
Ca-A Cancer Journal for Clinicians, 2023Mike Fillon
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Heterologous Prime-Boost COVID-19 Vaccination: Initial Reactogenicity Data
Lancet, The, 2021Matthew D Snape +2 more
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