Immunogens and Antigen Processing: Report from a Global HIV Vaccine Enterprise Working Group [PDF]
, 2010 The Global HIV Vaccine Enterprise convened a meeting of a Working Group in July 2009 to discuss recent progress in rational design of the components of an HIV vaccine, such as inserts, vectors and adjuvants,and in understanding antigen processing and ...
John Mascola +3 more
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Strategies for AIDS vaccines [PDF]
Journal of Antimicrobial Chemotherapy, 1996 In the global AIDS epidemic, over half of all infections have occurred in people less than 25 years old resulting in profound social, economic and demographic consequences. Current estimates indicate that the present 15 million HIV infections will increase to over 30 million by the end of the millennium.
E J, Stott, G C, Schild
openaire +2 more sources
Vaccine innovation, translational research and the management of knowledge accumulation [PDF]
, 2012 What does it take to translate research into socially beneficial technologies like vaccines? Current policy that focuses on expanding research or strengthening incentives overlooks how the supply and demand of innovation is mediated by problem-solving ...
Andre +86 more
core +2 more sources
Envelope Determinants of Equine Lentiviral Vaccine Protection [PDF]
, 2013 Lentiviral envelope (Env) antigenic variation and associated immune evasion present major obstacles to vaccine development. The concept that Env is a critical determinant for vaccine efficacy is well accepted, however defined correlates of protection ...
A Kumar +76 more
core +3 more sources
Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses
Cell Discovery, 2021 The origin and intermediate host for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is yet to be determined. Coronaviruses found to be closely related to SARS-CoV-2 include RaTG13 derived from bat and two clusters (PCoV-GD and PCoV-GX) of ...
Jianhui Nie +23 more
doaj +1 more source
Clofazimine: A Promising Inhibitor of Rabies Virus
Frontiers in Pharmacology, 2021 With an almost 100% mortality rate, rabies virus (RABV) infection is a global concern. Limited post-exposure prophylaxis and lack of an effective treatment necessitate novel antiviral therapies against RABV.
Jiajing Wu +16 more
doaj +1 more source
Analysis of the evolution, infectivity and antigenicity of circulating rabies virus strains
Emerging Microbes and Infections, 2022 Rabies virus has existed for thousands of years and is circulating in many species. In the present study, a total of 2896 rabies viruses isolated worldwide were phylogenetically classified into ten clusters based on the G gene sequence, and these ...
Meina Cai +12 more
doaj +1 more source
Neutralization of feline immunodeficiency virus by antibodies targeting the V5 loop of Env [PDF]
, 2010 Neutralising antibodies (NAbs) play a vital role in vaccine-induced protection against infection with feline immunodeficiency virus (FIV). However, little is known about the appropriate presentation of neutralisation epitopes in order to induce NAbs ...
Hosie, Margaret J. +6 more
core +1 more source
Child privacy rights: A ‘Cinderella’ issue in HIV-prevention research
Southern African Journal of HIV Medicine, 2013 Legal debates regarding child participation in HIV research have tended to focus on issues of informed consent. However, much less attention has been given to privacy; accordingly, we classify this as a ‘Cinderella issue’ that has been excluded from ‘the
Ann Elaine Strode, Catherine Slack
doaj +1 more source
An economic analysis of a pneumococcal vaccine programme in people aged over 64 years in a developed country setting. [PDF]
, 2005 BACKGROUND: Polysaccharide pneumococcal vaccination for older adults is being introduced in developed country settings. Evidence of protection by this vaccine against pneumococcal pneumonia, or confirmation that illness and death from bacteraemia are ...
Cutts, Felicity T +3 more
core +1 more source