Results 31 to 40 of about 53,072 (310)

Sex, lies and disclosures: Researchers and the reporting of under-age sex

Southern African Journal of HIV Medicine, 2009
Children are a vulnerable group and require legal protection due to their youth and inexperience. Resultantly, various provisions in the law ensure the care and protection of children through mechanisms such as the mandatory reporting of abuse.
Ann Strode, Catherine Slack
doaj   +1 more source

Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients

Signal Transduction and Targeted Therapy, 2021
Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of antibody regulated immune responses mediated through the Fc fragment. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered ADCC responses
Yuanling Yu, Meiyu Wang, Xiaoai Zhang, Shufen Li, Qingbin Lu, Haolong Zeng, Hongyan Hou, Hao Li, Mengyi Zhang, Fei Jiang, Jiajing Wu, Ruxia Ding, Zehua Zhou, Min Liu, Weixue Si, Tao Zhu, Hangwen Li, Jie Ma, Yuanyuan Gu, Guangbiao She, Xiaokun Li, Yulan Zhang, Ke Peng, Weijin Huang, Wei Liu, Youchun Wang   +25 more
doaj   +1 more source

Material aid for vaccines [PDF]

Nature Materials, 2018
Darrell Irvine provides an overview of the recent advances in materials science that have enabled the use of innovative natural and synthetic compounds in vaccine development capable of regulating the potency and safety of new vaccines progressing towards the clinic.
openaire   +2 more sources

Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system

Microbiology Spectrum
Dehong virus (DEHV) is an emerging filamentous virus of considerable interest. However, research involving DEHV remains limited, and no suitable models exist to investigate its pathogenicity or transmission.
Xuelian Wu, Fan Liu, Tao Li, Danfeng Li, Yanru Shen, Xiaoai Zhang, Shuo Liu, Qi Jiang, Chenyan Zhao, Jianhui Nie, Youchun Wang, Baomin Feng, Wei Liu, Weijin Huang   +13 more
doaj   +1 more source

Modeling the public health impact of malaria vaccines for developers and policymakers [PDF]

, 2013
Efforts to develop malaria vaccines show promise. Mathematical model-based estimates of the potential demand, public health impact, and cost and financing requirements can be used to inform investment and adoption decisions by vaccine developers and ...
Nunes, Julia K., Kårstein Måseide, Vicky Cárdenas, Loucq, Christian, Måseide, Kårstein, Nicolas Maire, Thomas Smith, Cárdenas, Vicky, Shaffer, Craig, Brooks, Alan, Maire, Nicolas, Julia K Nunes, Christian Loucq, Craig Shaffer, Smith, Thomas, Alan Brooks   +15 more
core   +1 more source

Ten emerging SARS-CoV-2 spike variants exhibit variable infectivity, animal tropism, and antibody neutralization

Communications Biology, 2021
Li Zhang, Zhimin Cui, and Qianqian Li et al. compare the infectivity, host tropism, and antigenicity of 10 SARS-CoV-2 variants using a VSV-based pseudovirus system. Their results suggest that variants carrying E484K display the most significant reduction
Li Zhang, Zhimin Cui, Qianqian Li, Bo Wang, Yuanling Yu, Jiajing Wu, Jianhui Nie, Ruxia Ding, Haixin Wang, Yue Zhang, Shuo Liu, Zhihai Chen, Yaqing He, Xiaodong Su, Wenbo Xu, Weijin Huang, Youchun Wang   +16 more
doaj   +1 more source

Progress Update on STING Agonists as Vaccine Adjuvants

Vaccines
Low antigen immunogenicity poses a significant challenge in vaccine development, often leading to inadequate immune responses and reduced vaccine efficacy. Therefore, the discovery of potent immune-enhancing adjuvants is crucial.
Yanru Shen, Weijin Huang, Jianhui Nie, Li Zhang   +3 more
doaj   +1 more source

The Antigenicity of Epidemic SARS-CoV-2 Variants in the United Kingdom

Frontiers in Immunology, 2021
To determine whether the neutralization activity of monoclonal antibodies, convalescent sera and vaccine-elicited sera was affected by the top five epidemic SARS-CoV-2 variants in the UK, including D614G+L18F+A222V, D614G+A222V, D614G+S477N, VOC-202012 ...
Jiajing Wu, Jiajing Wu, Li Zhang, Yue Zhang, Yue Zhang, Haixin Wang, Haixin Wang, Ruxia Ding, Jianhui Nie, Qianqian Li, Qianqian Li, Shuo Liu, Yongxin Yu, Yongxin Yu, Xiaoming Yang, Kai Duan, Kai Duan, Xiaowang Qu, Youchun Wang, Weijin Huang   +19 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Algorithms for Purchasing AIDS Vaccines

, 1999
The authors delineate two different algorithms for the purchase of AIDS vaccines, to show how differences in policy objectives can greatly affect projections of the number of courses of vaccine that will be
Kiyonga, C.W.B., Bishai, David, Maria K. Lin, Lin, Maria K., David Bishai, C. W. B. Kiyonga   +5 more
core   +1 more source