Results 31 to 40 of about 1,837,020 (236)

Progress Update on STING Agonists as Vaccine Adjuvants

Vaccines
Low antigen immunogenicity poses a significant challenge in vaccine development, often leading to inadequate immune responses and reduced vaccine efficacy. Therefore, the discovery of potent immune-enhancing adjuvants is crucial.
Yanru Shen, Weijin Huang, Jianhui Nie, Li Zhang   +3 more
doaj   +1 more source

Quest for the AIDS vaccine [PDF]

BMJ, 2007
Researchers broadly agree that the best way to halt the AIDS epidemic is to develop a vaccine against HIV.
openaire   +2 more sources

Glyceraldehyde-3-phosphate dehydrogenase common peptides of listeria monocytogenes, mycobacterium marinum and streptococcus pneumoniae as universal vaccines [PDF]

, 2021
Universal vaccines can be prepared with antigens common to different pathogens. In this regard, the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is a common virulence factor among pathogenic bacteria of the genera Listeria, Mycobacterium and ...
Del Molino-Bernal, I. Concepción Pérez, Torres-Rodriguez, Paula, Calvo-Montes, Jorge, David Salcines-Cuevas, Pérez Del Molino-Bernal, Concepción, Ricardo Calderón-Gonzalez, Manuel Fresno, Álvarez-Domínguez, Carmen, Teran-Navarro, Héctor, Fresno, Manuel, Raquel Tobes, Molino-Bernal, I Concepción Pérez Del, Paula Torres-Rodriguez, Carmen Alvarez-Dominguez, I. Concepción Pérez Del Molino-Bernal, Salcines-Cuevas, David, Fresno Escudero, Manuel, Pérez Del Molino Bernal, I. Concepción, Hector Terán-Navarro, Yañez-Diaz, Sonsoles, Jorge Calvo-Montes, Sonsoles Yañez-Diaz, Calderón-González, Ricardo, Tobes, Raquel   +23 more
core   +1 more source

A single mutation at position 214 of influenza B hemagglutinin enhances cross-neutralization

Emerging Microbes and Infections
High variability of influenza B virus (IBV) hemagglutinin (HA) impairs the cross- neutralization ability of vaccines, leading to reduce efficacy. We identified significant differences in cross-neutralization between IBV strains B/Wyoming/06/2014 and B ...
Ziqi Cheng, Yeqing Sun, Yanru Shen, Xi Wu, Ling Pan, Hao Wu, Yunbo Bai, Chenyan Zhao, Junfeng Ma, Weijin Huang   +9 more
doaj   +1 more source

Optimization of a High-Throughput Human Papillomavirus Neutralizing Antibody Assay Based on Pseudotyped Viruses for the 15-Valent Human Papillomavirus Vaccine Types

Viruses
Vaccination is highly effective in preventing human papillomavirus (HPV) infection, but traditional pseudovirion-based neutralization assays (PBNA) are technically demanding, labor-intensive, and costly, limiting their use in multivalent vaccine studies.
Huan Liu, Haiyang Qin, Lingling Nie, Yanru Shen, Jiayi Li, Pengcheng Xiu, Shasha Wang, Meng Wang, Youchun Wang, Jianhui Nie, Weijin Huang, Li Zhang   +11 more
doaj   +1 more source

Neutralizing antibodies against adenovirus type 2 in normal and HIV-1-infected subjects: Implications for use of Ad2 vectors in vaccines

Human Vaccines & Immunotherapeutics, 2017
Pre-existing neutralizing antibodies (NAbs) directed against vaccine vectors have attracted considerable research attention. Therefore, our aim was to establish a high-throughput economical neutralization assay to investigate the epidemiology of ...
Qianqian Li, Qiang Liu, Weijing Huang, Aijing Song, Chenyan Zhao, Jiajing Wu, Youchun Wang   +6 more
doaj   +1 more source

Material aid for vaccines [PDF]

Nature Materials, 2018
Darrell Irvine provides an overview of the recent advances in materials science that have enabled the use of innovative natural and synthetic compounds in vaccine development capable of regulating the potency and safety of new vaccines progressing towards the clinic.
openaire   +2 more sources

The Current Status in Terms of Vaccination for Individuals Infected with Human Immunodeficiency Virus

Viruses
Human immunodeficiency virus (HIV)-infected individuals have an increased risk of various infections due to their impaired host immune system, resulting in higher morbidity and mortality rates.
Nan Xu, Yanru Shen, Weijin Huang, Jianhui Nie   +3 more
doaj   +1 more source

The Antigenicity of Epidemic SARS-CoV-2 Variants in the United Kingdom

Frontiers in Immunology, 2021
To determine whether the neutralization activity of monoclonal antibodies, convalescent sera and vaccine-elicited sera was affected by the top five epidemic SARS-CoV-2 variants in the UK, including D614G+L18F+A222V, D614G+A222V, D614G+S477N, VOC-202012 ...
Jiajing Wu, Jiajing Wu, Li Zhang, Yue Zhang, Yue Zhang, Haixin Wang, Haixin Wang, Ruxia Ding, Jianhui Nie, Qianqian Li, Qianqian Li, Shuo Liu, Yongxin Yu, Yongxin Yu, Xiaoming Yang, Kai Duan, Kai Duan, Xiaowang Qu, Youchun Wang, Weijin Huang   +19 more
doaj   +1 more source

mRNA vaccine based on high-frequency prevalent antigens provides broad protection against influenza B virus

Molecular Therapy: Nucleic Acids
Influenza B virus (IBV) is a major pathogen affecting the human respiratory tract. B/Victoria is currently the only prevalent influenza B lineage as B/Yamagata has become increasingly rare.
Ziqi Cheng, Yeqing Sun, Yunbo Bai, Xi Wu, Ziqi Sun, Qingfeng Zhang, Weijin Huang, Junfeng Ma, Chenyan Zhao   +8 more
doaj   +1 more source