Results 11 to 20 of about 1,837,020 (236)

Nipah pseudovirus system enables evaluation of vaccines in vitro and in vivo using non-BSL-4 facilities

Emerging Microbes and Infections, 2019
Because of its high infectivity in humans and the lack of effective vaccines, Nipah virus is classified as a category C agent and handling has to be performed under biosafety level 4 conditions in non-endemic countries, which has hindered the development
Jianhui Nie, Lin Liu, Qing Wang, Ruifeng Chen, Tingting Ning, Qiang Liu, Weijin Huang, Youchun Wang   +7 more
doaj   +1 more source

Development of a Triple-Color Pseudovirion-Based Assay to Detect Neutralizing Antibodies against Human Papillomavirus

Viruses, 2016
Pseudovirion-based neutralization assay is considered the gold standard method for evaluating the immune response to human papillomavirus (HPV) vaccines.
Jianhui Nie, Yangyang Liu, Weijin Huang, Youchun Wang   +3 more
doaj   +1 more source

Review of efficacy trials of HIV-1/AIDS vaccines and regulatory lessons learned: A review from a regulatory perspective.

Biologicals (Print), 2016
The clinical development of prophylactic HIV-1/AIDS vaccines is confounded by numerous scientific challenges and these in turn result in challenges to regulators reviewing clinical trial applications (CTAs). The search for an HIV-1/AIDS vaccine will only
R. Sheets, Tie-Qun Zhou, I. Knezevic
semanticscholar   +1 more source

Retrospective immunogenicity analysis of seasonal flu H3N2 vaccines recommended in the past ten years using immunized animal seraResearch in context

EBioMedicine, 2022
Summary: Background: Influenza A (H3N2) virus (A/H3N2) has complex antigenic evolution, resulting in frequent vaccine strain updates. We aimed to evaluate the protective effect of the vaccine strains on the circulating strains from past ten years and ...
Mengyi Zhang, Yimeng An, Xi Wu, Meina Cai, Xinyu Zhang, Chaoying Yang, Jincheng Tong, Zhimin Cui, Xueli Li, Weijin Huang, Chenyan Zhao, Youchun Wang   +11 more
doaj   +1 more source

Prospects for an AIDS vaccine [PDF]

Nature Medicine, 2004
Several lines of evidence indicate that development of an effective vaccine for HIV-1 is going to be, at best, extremely difficult. The inability to solve fundamental scientific questions is the root cause for why a successful vaccine is not currently within our grasp.
openaire   +2 more sources

AIDS Vaccines and Preexposure Prophylaxis: Is Synergy Possible?

AIDS Research and Human Retroviruses, 2011
While the long-term goal is to develop highly effective AIDS vaccines, first generation vaccines may be only partially effective. Other HIV prevention modalities such as preexposure prophylaxis with antiretrovirals (PrEP) may have limited efficacy as ...
J. Excler, W. Rida, F. Priddy, J. Gilmour, A. McDermott, A. Kamali, O. Anzala, G. Mutua, E. Sanders, W. Koff, S. Berkley, P. Fast   +11 more
semanticscholar   +1 more source

Planning for new health interventions for developing countries : an integrated strategy to prepare for malaria vaccines and lessons for future interventions [PDF]

, 2011
Historically, new health interventions have been developed primarily to address the needs of the wealthy in developed countries. Where drugs, vaccines, diagnostic tests and other interventions happened to address diseases prevalent in the developing ...
Brooks, Alan
core   +1 more source

Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses

Cell Discovery, 2021
The origin and intermediate host for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is yet to be determined. Coronaviruses found to be closely related to SARS-CoV-2 include RaTG13 derived from bat and two clusters (PCoV-GD and PCoV-GX) of ...
Jianhui Nie, Qianqian Li, Li Zhang, Yang Cao, Yue Zhang, Tao Li, Jiajing Wu, Shuo Liu, Mengyi Zhang, Chenyan Zhao, Huan Liu, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Junkai Liu, Haoyu Liang, Taijiao Jiang, Kai Duan, Xiaoming Yang, Yuelei Shen, Weijin Huang, Youchun Wang   +23 more
doaj   +1 more source

Analysis of the evolution, infectivity and antigenicity of circulating rabies virus strains

Emerging Microbes and Infections, 2022
Rabies virus has existed for thousands of years and is circulating in many species. In the present study, a total of 2896 rabies viruses isolated worldwide were phylogenetically classified into ten clusters based on the G gene sequence, and these ...
Meina Cai, Haizhou Liu, Fei Jiang, Yeqing Sun, Wenbo Wang, Yimeng An, Mengyi Zhang, Xueli Li, Di Liu, Yuhua Li, Yongxin Yu, Weijin Huang, Youchun Wang   +12 more
doaj   +1 more source

Clofazimine: A Promising Inhibitor of Rabies Virus

Frontiers in Pharmacology, 2021
With an almost 100% mortality rate, rabies virus (RABV) infection is a global concern. Limited post-exposure prophylaxis and lack of an effective treatment necessitate novel antiviral therapies against RABV.
Jiajing Wu, Jiajing Wu, Shouchun Cao, Shan Lei, Qiang Liu, Yinghong Li, Yueyang Yu, Hui Xie, Qianqian Li, Xiaoqiang Zhao, Ruifeng Chen, Weijin Huang, Xinyue Xiao, Yongxin Yu, Danqing Song, Yuhua Li, Youchun Wang   +16 more
doaj   +1 more source