Results 21 to 30 of about 53,072 (310)

Planning for new health interventions for developing countries : an integrated strategy to prepare for malaria vaccines and lessons for future interventions [PDF]

, 2011
Historically, new health interventions have been developed primarily to address the needs of the wealthy in developed countries. Where drugs, vaccines, diagnostic tests and other interventions happened to address diseases prevalent in the developing ...
Brooks, Alan
core   +1 more source

Retrospective immunogenicity analysis of seasonal flu H3N2 vaccines recommended in the past ten years using immunized animal seraResearch in context

EBioMedicine, 2022
Summary: Background: Influenza A (H3N2) virus (A/H3N2) has complex antigenic evolution, resulting in frequent vaccine strain updates. We aimed to evaluate the protective effect of the vaccine strains on the circulating strains from past ten years and ...
Mengyi Zhang, Yimeng An, Xi Wu, Meina Cai, Xinyu Zhang, Chaoying Yang, Jincheng Tong, Zhimin Cui, Xueli Li, Weijin Huang, Chenyan Zhao, Youchun Wang   +11 more
doaj   +1 more source

Challenges of Continuum of HIV/AIDS Care and Treatment in Tanzania: The Effects of Parasites Co-Infections, HIV Clinical Manifestations, and Adherence to Antiretroviral Therapy [PDF]

, 2012
In Tanzania, the National AIDS Control Program with the support of Non-Government Organizations is scaling-up Antiretroviral Therapy (ART) services to peripheral (rural) health facilities.
Idindili, Boniphace
core   +1 more source

Functional comparison of SARS-CoV-2 with closely related pangolin and bat coronaviruses

Cell Discovery, 2021
The origin and intermediate host for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is yet to be determined. Coronaviruses found to be closely related to SARS-CoV-2 include RaTG13 derived from bat and two clusters (PCoV-GD and PCoV-GX) of ...
Jianhui Nie, Qianqian Li, Li Zhang, Yang Cao, Yue Zhang, Tao Li, Jiajing Wu, Shuo Liu, Mengyi Zhang, Chenyan Zhao, Huan Liu, Lingling Nie, Haiyang Qin, Meng Wang, Qiong Lu, Xiaoyu Li, Junkai Liu, Haoyu Liang, Taijiao Jiang, Kai Duan, Xiaoming Yang, Yuelei Shen, Weijin Huang, Youchun Wang   +23 more
doaj   +1 more source

The Development of an AIDS Mucosal Vaccine [PDF]

Viruses, 2010
It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens. In fact, more than 80% of infectious disease pathogens probably gain entry into the susceptible human hosts through open mucosal surfaces.
Tang, X, Chen, Z
openaire   +5 more sources

Clofazimine: A Promising Inhibitor of Rabies Virus

Frontiers in Pharmacology, 2021
With an almost 100% mortality rate, rabies virus (RABV) infection is a global concern. Limited post-exposure prophylaxis and lack of an effective treatment necessitate novel antiviral therapies against RABV.
Jiajing Wu, Jiajing Wu, Shouchun Cao, Shan Lei, Qiang Liu, Yinghong Li, Yueyang Yu, Hui Xie, Qianqian Li, Xiaoqiang Zhao, Ruifeng Chen, Weijin Huang, Xinyue Xiao, Yongxin Yu, Danqing Song, Yuhua Li, Youchun Wang   +16 more
doaj   +1 more source

Analysis of the evolution, infectivity and antigenicity of circulating rabies virus strains

Emerging Microbes and Infections, 2022
Rabies virus has existed for thousands of years and is circulating in many species. In the present study, a total of 2896 rabies viruses isolated worldwide were phylogenetically classified into ten clusters based on the G gene sequence, and these ...
Meina Cai, Haizhou Liu, Fei Jiang, Yeqing Sun, Wenbo Wang, Yimeng An, Mengyi Zhang, Xueli Li, Di Liu, Yuhua Li, Yongxin Yu, Weijin Huang, Youchun Wang   +12 more
doaj   +1 more source

Prospects for an AIDS vaccine [PDF]

Nature Medicine, 2004
Several lines of evidence indicate that development of an effective vaccine for HIV-1 is going to be, at best, extremely difficult. The inability to solve fundamental scientific questions is the root cause for why a successful vaccine is not currently within our grasp.
openaire   +2 more sources

Heterologous prime-boost-boost immunisation of Chinese cynomolgus macaques using DNA and recombinant poxvirus vectors expressing HIV-1 virus-like particles [PDF]

, 2011
Background: There is renewed interest in the development of poxvirus vector-based HIV vaccines due to the protective effect observed with repeated recombinant canarypox priming with gp120 boosting in the recent Thai placebo-controlled trial.
Bridge, S., Skinner, Michael A., Anson, Donald, Dennis, M., Simon H Bridge, Dowall, S., Blanchard, Tom J., Getty, B., Stewart, James, Dennis, Mike J., Dowall, SD, Donald S Anson, Anson, D., Dennis, MJ, Bridge, Simon H., Dowall, Stuart D., Blanchard, Thomas, Stewart, JP, Blanchard, T., Skinner, M., Stewart, James P., James P Stewart, Mike J Dennis, Getty, B, Michael A Skinner, Bridge, SH, Bridge, Simon, Sharpe, Sally, Sharpe, SA, Skinner, MA, Getty, Brian, Brian Getty, Dennis, Mike, Blanchard, Tom, Sharpe, Sally A., Anson, DS, Sally A Sharpe, Skinner, Michael, Stuart D Dowall, Tom J Blanchard, Blanchard, TJ, Anson, Donald S., Stewart, J., Sharpe, S., Dowall, Stuart   +44 more
core   +1 more source

Child privacy rights: A ‘Cinderella’ issue in HIV-prevention research

Southern African Journal of HIV Medicine, 2013
Legal debates regarding child participation in HIV research have tended to focus on issues of informed consent. However, much less attention has been given to privacy; accordingly, we classify this as a ‘Cinderella issue’ that has been excluded from ‘the
Ann Elaine Strode, Catherine Slack
doaj   +1 more source