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The Development of an AIDS Mucosal Vaccine [PDF]
Viruses, 2010 It is well known that mucosal tissues contain the largest surface area of the human body and are the front line of natural host defense against various pathogens. In fact, more than 80% of infectious disease pathogens probably gain entry into the susceptible human hosts through open mucosal surfaces.
Tang, X, Chen, Z
openaire +5 more sources
PLoS ONE, 2010 Background HIV-1 clade C (HIV-C) predominates worldwide, and anti-HIV-C vaccines are urgently needed. Neutralizing antibody (nAb) responses are considered important but have proved difficult to elicit.
N. Siddappa +14 more
semanticscholar +1 more source
Development of Streptococcus pneumoniae Vaccines Using Live Vectors [PDF]
, 2015 : Streptococcus pneumoniae still causes severe morbidity and mortality worldwide, especially in young children and the elderly. Much effort has been dedicated to developing protein-based universal vaccines to conquer the current shortcomings of capsular ...
core +1 more source
Feline Immunodeficiency Virus Model for Designing HIV/AIDS Vaccines
Current HIV Research, 2010 Feline immunodeficiency virus (FIV) discovered in 1986 is a lentivirus that causes AIDS in domestic cats. FIV is classified into five subtypes (A–E), and all subtypes and circulating intersubtype recombinants have been identified throughout the world.
J. Yamamoto +3 more
semanticscholar +1 more source
Child privacy rights: A ‘Cinderella’ issue in HIV-prevention research
Southern African Journal of HIV Medicine, 2013 Legal debates regarding child participation in HIV research have tended to focus on issues of informed consent. However, much less attention has been given to privacy; accordingly, we classify this as a ‘Cinderella issue’ that has been excluded from ‘the
Ann Elaine Strode, Catherine Slack
doaj +1 more source
Microbiology SpectrumDehong virus (DEHV) is an emerging filamentous virus of considerable interest. However, research involving DEHV remains limited, and no suitable models exist to investigate its pathogenicity or transmission.
Xuelian Wu +13 more
doaj +1 more source
Sex, lies and disclosures: Researchers and the reporting of under-age sex
Southern African Journal of HIV Medicine, 2009 Children are a vulnerable group and require legal protection due to their youth and inexperience. Resultantly, various provisions in the law ensure the care and protection of children through mechanisms such as the mandatory reporting of abuse.
Ann Strode, Catherine Slack
doaj +1 more source
Antibody-dependent cellular cytotoxicity response to SARS-CoV-2 in COVID-19 patients
Signal Transduction and Targeted Therapy, 2021 Antibody-dependent cellular cytotoxicity (ADCC) responses to viral infection are a form of antibody regulated immune responses mediated through the Fc fragment. Whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) triggered ADCC responses
Yuanling Yu +25 more
doaj +1 more source
Use of Nonhuman Primate Models to Develop Mucosal AIDS Vaccines
Current HIV/AIDS Reports, 2010 The HIV vaccines tested in the halted Step efficacy trial and the modestly successful phase 3 RV144 trial were designed to elicit strong systemic immune responses; therefore, strategies to direct immune responses into mucosal sites should be tested in an
M. Genescà, C. Miller
semanticscholar +1 more source
Communications Biology, 2021 Li Zhang, Zhimin Cui, and Qianqian Li et al. compare the infectivity, host tropism, and antigenicity of 10 SARS-CoV-2 variants using a VSV-based pseudovirus system. Their results suggest that variants carrying E484K display the most significant reduction
Li Zhang +16 more
doaj +1 more source