Results 91 to 100 of about 2,566,710 (296)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Prime Graphs with Almost True Twin Vertices
MathematicsA graph G consists of a possibly infinite set V(G) of vertices with a collection E(G) of unordered pairs of distinct vertices, called the set of edges of G. Such a graph is denoted by (V(G),E(G)).
Aymen Ben Amira, Moncef Bouaziz
doaj +1 more source
Congruences for Wolstenholme primes [PDF]
, 2011 A prime number $p$ is said to be a Wolstenholme prime if it satisfies the congruence ${2p-1\choose p-1} \equiv 1 \,\,(\bmod{\,\,p^4})$. For such a prime $p$, we establish the expression for ${2p-1\choose p-1}\,\,(\bmod{\,\,p^8})$ given in terms of the ...
Mestrovic, Romeo
core
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Laser Fluorescence Imaging of Vascular Territories in Lipoabdominoplasty
Plastic and Reconstructive Surgery, Global OpenBackground:. Although limited dissection is commonly thought to enhance flap perfusion during abdominoplasty, recent evidence indicates otherwise. This study used intraoperative fluorescence imaging to elucidate the dynamic role of vascular territories ...
Giuliano B. Borille, MD +5 more
doaj +1 more source
Nature Catalysis, 2018 The carboxylation of aromatic compounds with CO2 is an attractive reaction, albeit limited in scope. Now, bulky ligands in a Rh(II) catalysed C–H carboxylation of 2-arylphenols are shown to override the standard ortho/para Kolbe-Schmitt-type regioselectivity allowing instead carboxylation at 2’
Spencer, Andrew +2 more
openaire +4 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
, 2004 We present a simple, closed formula which gives all the primes in order. It is a simple product of integer floor and ceiling functions.
openaire +2 more sources